<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP16145
Description |
Mediator of RNA polymerase II transcription subunit 14 (Fragment) |
Sequence | MAELGQQTVEFSLLVRRAAEDSFLSLKELVEQLKKTEQSDTDKKINILKYIQRTRQRMLRLHVLAKWCRQVPVVQYCQQLASTLSSHDTCFTQAADSLFFMHEGLQQARAPIYDVPSAIEVLLTGSYQRLPKCIEDMGIQGTLTEDQQKPALKKLDTLLRSKLLEVTLPKEISEVKVSDGTVHLRVNGEFKVLLTLGYRGHLSMWRILHLELLVGEKSGHVKLEESRRHVLGDDLERRMSAAENPFLVLYSVLHELCVALIMDTVLRQVHALRQGRWRDAIRFELISDGGPGQGGNAGSIQTNQDGEADSAGLKTPGLKIIYWLDFEKNNGVSDPGVCPFIKIEPWQDLQVKCLHSAFVIDPLTGKEAEFFLDQSCIDVEKLLLRVISCNRYTRLLEILKNLRKVGQISQAPDDILLQCYEDNSGSAMSK |
Length | 430 |
Position | Tail |
Organism | Aquilegia coerulea (Rocky mountain columbine) |
Kingdom | Viridiplantae |
Lineage | Eukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta>
Spermatophyta> Magnoliopsida> Ranunculales> Ranunculaceae> Thalictroideae>
Aquilegia.
|
Aromaticity | 0.06 |
Grand average of hydropathy | -0.208 |
Instability index | 42.81 |
Isoelectric point | 6.44 |
Molecular weight | 48609.56 |
Publications | |
Function
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU365082
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GO - Cellular Component | mediator complex GO:0016592 IEA:UniProtKB-UniRule
|
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:UniProtKB-UniRule
|
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro
|
Interaction
Repeat regions
Repeats |
>MDP16145
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 116.32| 38| 220| 14| 56| 3
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14- 56 (56.17/33.50) LVRR..AAEDSFLSLKELVEQLKKTEQSDTdkkinILKYIQRTRQ
235- 274 (60.15/27.70) LERRmsAAENPFLVLYSVLHELCVALIMDT.....VLRQVHALRQ
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 108.77| 34| 36| 130| 163| 4
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130- 163 (56.99/40.41) LPKCIEDMGIQGTLTEDQQKPALKKLDTL.LRSKL
168- 202 (51.78/36.07) LPKEISEVKVSDGTVHLRVNGEFKVLLTLgYRGHL
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