<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP16103

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMAELGQQTVDFSMLVHRAAEDSFLLLKELVEQLKKSEQSDTEKKISILKYIQKTRQRMLRLDVVAKWCRQVPVVQYCQQLASTLSSHDTCFTQAADSLFFMHEGLQQARAPIYDVPSAIEVLLTGSYQRLPKCIEDMGVQSSLTEDQQKPALKKLETLLRSRLLEITLPKEISEVKVSDGTVHLCVNGEFKVILTLGYRGHLSMWRILHLELLVGEKSGHVKLEESRRHVLGDDLERRMAAAENPFLLLYSILHELCVALIMDTVLRQVQALRQGRWRDAIRFELISDGPAGQGGSAGPTPMSQDGETDSSNKKIPGLKILYWLDFGKNNGGSDSGLCPYIKIEPSQVLQVKCLHSTFVIDPLTGKEADFSLDQSCVDVEKLLLRVISCNRYTRLLVILEELRKIGQICQAADDVLLQCYEDNSDLDMRKKDNKSNPRAFGGKEVLRVRAYNSSYITLGINIRSGHFYLQSSRNVLTASSLSECEEALNQGGMTAVEVFISLRSKSILRLIASVGKFLGLQVYEQGLAAVKIPNALLNGSGVLLMGLPQCGGSYFLLIQLDHNFKALFQLLETQQDSNGKFLTGGKLNQVIRFNDIDIDRTQMLRDESTLSLLERGNLISSFPNVVGSNQTSERGLLSECGLDASMQIAAGSPQSSFSSVVNELFALEKGMSAPPFPVRSNLSSSFITSPTINLGSVPINYQKTKFGITSPKWDGSLQQSSPGRSPALQKLSSSKSEQDITSLRSAHAVEAGSAINEHQVVYSSRSSRLLHPLRPTGPSVTPVRNVIDLGSPTTTTRNAIGSSRAGQAPESGFPNKSNYEVSKYDINPRKRSISDLLSLVPSLEGTKKRRKLSETALRHTPASQVARSSDFIGKIDGCSYGNLLAEANKGNAPSSIYVTALLHVVKHCSLCIKHARLTSQMAALDIPYIEEAGLQIPSSNVWFRLPFAREMSWQHLCLRLGRPGSMSWDVKIDDQHFRDLWELQKGSTNTPWGSGVRIATASDIDSHIRYDSDGVILTYESVEDDSIKKLVADISRLFNARLFSLGMRELLGVRTDDKPEEGSATLENKTSIGSKVDVEFPDKISEQLRKAFRIEAVGLMSLWFSFGPGVLARFVVEWESGKEGCTMHVSPDQLWPHTKFLEDFINGAEVASLLDCIRLTAVPLHALAAATRPARAGPASGSLSAMPGSSPIPKQNAFVLPSSSLSNVNQTTPVPPAASSVASSVMVSLGSHALHGAAMLAAGRGGPGIVPSSLLPFDVSVVLRGPYWIRIIYRKDFAVDMRCFGGDHVWLQPATPPKEGHAVGGSLPCPQFRPFIMEHVAQELNGLEPNLSVGQQTVGLVNLNSPNPSLGSQLAVASGNRSANASGIVRPASLPGNHVTGLSRIGNGPMASSNLSASSGMPLRRSLGTGVPIHLRGELNTAFIGLGDDGGYGGGWVPLVALKKVLRGILKYLGVLWLFAQLPDLLKEILSSILKDNEGALLNLDQEQPALRFFVGGYVFAVSVHRVQLLLQVLSTKRFHHQQQQQSQGSTQEELAQTEISEICDYFSRRVASEPYDASRVASFITLLTLPISVLREFLKLIAWKKGLLVQGGDLAQAQKPRIELCLENHSGMPQGGNSDNSSSKSNIHHDRPHNSVDFALTVVLDPAHIPHINAAGGAAWLPHCVSVRLRYSFGENPRVMFLGMEGSHGGRSCWLRLEDWESCKQRVVQTVEDNRTMTGDVVSQGRLRKVADSVQRTLQLCLQGMRDNSVTAASSGAV
Length1759
PositionTail
OrganismAquilegia coerulea (Rocky mountain columbine)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> Ranunculales> Ranunculaceae> Thalictroideae> Aquilegia.
Aromaticity0.06
Grand average of hydropathy-0.150
Instability index49.68
Isoelectric point8.38
Molecular weight192304.62
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP16103
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      48.86|      15|      51|     613|     632|       1
---------------------------------------------------------------------------
  613-  627 (26.88/ 8.60)	LERGNLISSFPNVVG
  637-  651 (21.98/12.44)	LSECGLDASMQIAAG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     220.50|      62|     116|    1188|    1256|       2
---------------------------------------------------------------------------
 1188- 1241 (79.11/40.05)	..........................................................GSSPIPKQNAFVLPS.........SSLSNVNQT...TPVPPAASSVASSVMVSLGSHALHGAAM.LA
 1248- 1366 (53.15/37.52)	GIV.PSSlLPfdvsvvlrgpywiriiyrkdfavdmrcfggdhvwlqpatppkeghavgGSLPCPQFRPFIMEHvaqelnglePNLSVGQQTvglVNLNSPNPSLGSQLAVASGNRSANAS.....
 1367- 1427 (88.23/43.55)	GIVrPAS.LP................................................GNHVTGLSRIGNGPM.........AS.SNLSAS...SGM.PLRRSLGTGVPIHLRGE.LNTAFIgLG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     143.62|      41|     248|     797|     837|       3
---------------------------------------------------------------------------
  740-  784 (43.88/25.85)	...ITSLRSAHAVEAGsainehqvvYSSRSSRLL..HPLRPTGPSVTPVR
  797-  837 (67.39/44.19)	RNAIGSSRAGQAPESG.........FPNKSNYEVSKYDINPRKRSISDLL
  849-  876 (32.35/16.86)	RRKLSETALRHTPASQ.........VARSSDF.IGKID............
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      75.28|      25|     573|     127|     155|       5
---------------------------------------------------------------------------
  127-  153 (40.23/45.36)	YQRLPKCIEDmgVQSS.........LTEDQQKPALK
 1459- 1492 (35.05/21.74)	FAQLPDLLKE..ILSSilkdnegalLNLDQEQPALR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     112.74|      30|      35|     517|     546|       8
---------------------------------------------------------------------------
  492-  510 (18.84/ 7.57)	.........GMTAVEVFISLRSKS..ILRL
  517-  546 (47.92/32.27)	FLGLQVYEQGLAAVKIPNALLNGSGVLLMG
  555-  584 (45.97/30.61)	FLLIQLDHNFKALFQLLETQQDSNGKFLTG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      99.65|      27|     403|    1266|    1292|      10
---------------------------------------------------------------------------
 1266- 1292 (54.48/32.79)	PYWIRIIYRKDFAVDMRCF........GGDHVWLQ
 1663- 1697 (45.17/25.97)	PHCVSVRLRYSFGENPRVMflgmegshGGRSCWLR
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP16103 with Med14 domain of Kingdom Viridiplantae
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