<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP16048

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMWTNVFKIGGLHQISWFQFLPSESDLNPLPDKSVKAEQKDAATLLVLLSHLQLQKEGFLSTWTNSFVGPWDPSQGMHNPDEKIKLWLFIPGRHSSVLETAQSAVSRLRVVGSGLWVAPGDSEEVAVALSQALRNCIERALRGISYMRYGDVFTRCYPFSQSGKQSRRVQPTVEFIFAATEEALFVHVIISAKHIRSLSRDDMEKILRRCSPRKHGERLPVIVAPHGMRGQLSGCCPSDLVKQVYLSSSKVKASNGFTVVNIPSNVAQASGCQLRGQNCHVEVTLGCPGTGDKAVHLNSNFIWNKPNHHSTESPMVALDRDDQKHGSTDYYRVSERTFIYPAEAVVVPVMQTTFARSSLKRFWLQNWAGAALFGSCFLTNCSGFGRVGSSESMYQPWIDSNGIRSQNSSSNSNNSSVSGITGSSSGSDYQMISGAGDLEADADSFTCRQSGLSSNDQLENDDNKQVCKRARKGTSESFNGAGTVLNTDIEVKTSIVGAVNDQVGSLWDWDAEERVELDIQILLSDFGDFGDFFPPGTDESQAIVYSVLDCGDVNGSPCAGAMDVTDQMLLPALEFPSFDSINPLPLVVTDESQSKQQELEKDTWSSALGSYSSALSAGEFDTLSKAEAMMTFAPEYTAVEAPPNELLAQTFRSPYLPVSRKVERSNFSSSAYAYGATPPSSCLTFPDQNPSMSQNIKTCPAGLESSHAMNYKKCYTHVTMEKEIDGKLIDCNNNIASSEGLRPSSSFSGYNSINTVKSLKRKRAEENTEPRNILLSLEIVIASEVECIMFQASMCRIRHMPSLSSNLLSSVPSNFTGNSALEHPRGDNLTISDKTSSRYDVKKKESIPVRIAGDVDVGMLDGSFNAPVGVWRSVGVPKGAKPTSSSSIDNAPSFHNNSFNEESRHMYGQRQPLQELLNAMTLLVQQATSFVDVALDAEYGDGPFGWLALEEQSRRGFSCGPSMVHAGCGGVLATCHSLDIAGVELLDPLSSNVHASSVISLLHSDIKVALKSAFGNLDGPLLVTDWCKGRNQLSDTGNPNDVYSGESATGDAKDSLSAVTLAAGEPMSPTNSSGGSSCLKDGVRVDETTQRRLNQEIGSSESDQQLNSSRLRPTLLLLPMPAILVGYQDDWLKTSTSSLQLWEKAPLEPYAAPKPTTYYVVCPDIDPLASAAADFFQQLGTVYETCKLGTHTPQNMGAQTDLLSGKWASSGFVMIDCPQSMKMESGKASIMGSISDYLLALSNAWDVRSFLKSLSNVIKALRLGPNSTTNPKEGSSGPGMVIYVVCPFPEPVAVLQTVIESSTALGSTIVSSDKERRSLLHNQVARALSCSVAVDEASLSNILTISGFSIPKLVLQIVTVEAILRVTSPALNELVLLKEIAFTVYNKSRRLARVSNNDVVQSPGVSVRPQSTMMHMASPISGMWKDCIAPRITGSLPREGELDTSLRGGTWENSWQAARTGGLSCDQNRLGDKICQDDVRYLFEPLFVLAEPGSVEQGVSPMMVSNAMVDSPRPAVDDGSSGGFVQCSTSVGADIGPSSLHEGSESDGCGHSHPKTTSLHCCYGWTEDWRWLVCVWTDSRGEFLDSQIFPFGGIGSRQDTKGLQCLFVQVLHQGCQILSCSSPDAGSIKPRDIIITRIGSFYELERQEWQKAIYLVGGNEVKKWPLQLRRSVPDGISASNGNSLHQQGMSLIQDRTLSSSPNPSMYSPQTKASGYIKGGLGQMNARKTGGQAAVDNSRGLFLWVRSISLIGVSVDHSLHLILQADTPLSGGGAQGAAATGPVGYLEGFSPVKSLGSTSASYILIPSPSMHFLPPKPLQLPTCLTSDSPPLAHLLHSKGSAIPLSTGFVVSKAVPSIQKDTRSSMKEEWPSILSVSLVDYYGSSNIPQEKIARGSIKHARSINSDARDHEIETHLILESVAAELHALSWMTASPAYLERRTALPFHCDMILRLRRLIHYADKEICQKPDKVQM
Length1971
PositionKinase
OrganismAquilegia coerulea (Rocky mountain columbine)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> Ranunculales> Ranunculaceae> Thalictroideae> Aquilegia.
Aromaticity0.07
Grand average of hydropathy-0.231
Instability index49.90
Isoelectric point5.79
Molecular weight213592.64
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP16048
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     389.50|     127|     548|     828|    1075|       1
---------------------------------------------------------------------------
  909- 1075 (189.49/32.66)	RQPLQELLNAMTLLVQQAtsFVDVALDAeYGDGPFGWLaLEEQSRRGFSCGPSMVHA.....GCGgvlatchsldiagvelldplssnvhassvisllHSDIK.VALKSAFG.NLDGPLLVTDWCKGRNQLSDTGN.PndvYSGESATGDAK..DSLSAVTLAAG.EPMSPTNSSGGS
 1489- 1626 (200.02/135.59)	AEPGSVEQGVSPMMVSNA..MVDSPRPA.VDDGSSGGF.VQCSTSVGADIGPSSLHEgsesdGCG.................................HSHPKtTSLHCCYGwTEDWRWLVCVWTDSRGEFLDSQIfP...FGGIGSRQDTKglQCLFVQVLHQGcQILSCSSPDAGS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     325.69|      77|     552|     194|     277|       2
---------------------------------------------------------------------------
  194-  273 (129.11/78.59)	IRSLSRDDMEKilrRCSPRKHGERLPVIVAP..HGMRGQLSGCCPSD...LVKQVYLSSSKVKASNGFTVVN.IPSNVAQASGCQL
  755-  822 (100.02/53.10)	VKSLKRKRAEE...NTEPRNILLSLEIVIASevECIMFQASMC.......RIRHMPSLSSNLLSS........VPSNFTGNSALEH
 1186- 1225 (44.80/19.13)	......................................KLGTHTPQN...MGAQTDLLSGK.WASSGFVMID.CPQSMKMESG...
 1805- 1854 (51.75/23.63)	................SPSMH..FLP....P..KPL..QLPTCLTSDsppLAHLLHSKGSAIPLSTGFVVSKaVPS..........
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      68.23|      21|     551|      20|      40|       3
---------------------------------------------------------------------------
   20-   40 (38.42/24.96)	LPSESDLNPLP....DKSVKAEQ...KD
  574-  601 (29.81/17.39)	FPSFDSINPLPlvvtDESQSKQQeleKD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      88.81|      26|     550|     828|     881|       4
---------------------------------------------------------------------------
  843-  870 (43.50/64.77)	KESIPVRIAGDVD.VGMLDGSFNApvGVW
 1424- 1450 (45.31/11.46)	KDCIAPRITGSLPrEGELDTSLRG..GTW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      63.97|      22|      45|     433|     456|       5
---------------------------------------------------------------------------
  433-  456 (30.50/28.39)	GAGD.LEADADSFTcRQSGlSSNDQ
  479-  501 (33.47/19.68)	GAGTvLNTDIEVKT.SIVG.AVNDQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      88.39|      23|     122|    1145|    1168|       6
---------------------------------------------------------------------------
 1145- 1168 (42.16/30.84)	PLEPYAAPkPTTYYVVCPDIDPLA
 1270- 1292 (46.23/29.27)	PKEGSSGP.GMVIYVVCPFPEPVA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      80.12|      22|     319|     410|     431|       7
---------------------------------------------------------------------------
  410-  431 (39.98/26.02)	NSNNSSVSGITGSSSGSDYQMI
  731-  752 (40.14/26.15)	NNNIASSEGLRPSSSFSGYNSI
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP16048 with Med13 domain of Kingdom Viridiplantae
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