<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP15956

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMAELGQQTVDFSALVSRAAEESYVTLKELVEKCKSSDLSDSEKKIGILKYVVKTQQRMLRLNVLSKWCQQVPLIQYCQQLASTLSSHDTCFTQAADSLFFMHEGLQQARAPIYDVPSAVEVLLTGSYGRLPKCIGDLGLQSSLNDDQQKPALKKLDALVRSKLLEVSLPKDITEVKVSDGTVLLRVDGEFKVLVTLGYRGHLSMWRILHMELLVGERSGLMKLDDFRRHALGDDLERRMAAADNPFMTLYSILHELCVALVMDTVIRQVQTLRQGRWKDAIRFELITDGSTGQGSSAGSTQTSQDGESESASLRTPGLKILYWLDLDKNIGTSEIGTCPFIKIEPGPDLRIKCLHSTFVIDPLTGKEAEFSLDQSCIDIEKLLLRVICCNRYTRLLEIFKEVEKNGQICRVPGDVQLQCHVEEVLADSRKKDNKFDSREYQGQEVLRVRAFGSSFFTLAINIRNGHFILHSSKNVISSSVVVECEEALNQGSMSAAEAFNSLRSKSILHLFACIGRFLGLEVFEHGSASVKVPKSISCGTNFLLMGFPECGSSYFLLMELDKDFKPVFKLLESQSDSPAKAQPLADLSNMVRVKTIDVGRMQICEDKLNLSLLNSKKLLSILPSDGRSHQSSENSLLADFSLEGSIVASSAPSAFSSIVDEMFELEKGSSVPSFSGQLPPSTFGAPPASHFGSGVANYQNLKVGTLSPKWDRGAGNYSSSIYKGVIQSGSAGSLAATPGRIQTGKKLPASKSEQDLTSLRSPHSAGVGSYTSLDEDQLTVSSNRSARLLSPAQRVSASSGKASGPRNSAVGTLPAQAIDSATCTKSEQDAASRYNILPRKRTLSDLLDSLPSLKAMQSNEGSYKRRKLVESAGTHLSKSPMLISSDISGKTEEYSYGSLIAEANKGNAPSSIYVSALLHVVRHCSLCIKHARLTSQMEELDIPYVEEVGLRSASSNLWFRVPFARDDGWQHICLRLGRPGSMYWDVKINDQHFQDLWELQKGSNSTPWGSGVRIANTSDADSHIRYDCEGVVLSYYSVNADSIKKLVADIQRLSNARTFAFGMRKLLGARADEKFEENNVNSESKASAAIKGSADATDRISEQMRKQFRIEAVGLMSLWFSFGSGVLARFVVEWESGKEGCTMHVSPDQLWPHTKFLEDFINGAEVASLLDCIRLTAGPLHALAAATRPARAAPVSGVPGVTAPISSAAKQASYVPSLPSNVNSSINQPASGPGVNPVSATVGTLGTHSHPSAAMLAAAGRGGPGIVPSSLLPIDVSVVLRGPYWIRIIYRKKFAVDMRCFAGDQVWLQPATPPKGGPEVGGSLPCPQFRPFIMEHVAQELNGIDNFTGSQQAVGLTNSNSINAGSQLPAANTNRNNLSNSTGLTRPANAVNGFSRTANGLPAASNLAGVNAGMPLRRQPGTGVPAHVRGELNTAIIGLGDDGGYGGGWVPLVALKKVLRGILKYLGVLWLFAQLPDLLKEILGSILKDNEGALLNLDQEQPALRFFVGGYVFAVSVHRVQLLLQVISVKRFHQSQQQQQQNPGSAQEELTQSEIGEICDYFSRRVASEPYDASRVASFITLLTLPISVLREFLKLIAWKKGLSQVQGGDMVPTQKSRIELCLENHGGYSNDGSSENTSASKSNIHYDRAHNSVDFALTVVLDHAHIPHINAAGGAAWLPYCVSVRLRYAFGENPNVLFLGMEGSHGGRACWLRVDDWDRCKQRVARTVEVNGNSAGDANQGRLRVVADSVQRTLHAYLPGLRDGGGIAAGIGS
Length1774
PositionTail
OrganismCapsicum chinense (Scotch bonnet) (Bonnet pepper)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> eudicotyledons> Gunneridae> Pentapetalae> asterids> lamiids> Solanales> Solanaceae> Solanoideae> Capsiceae> Capsicum.
Aromaticity0.07
Grand average of hydropathy-0.174
Instability index44.00
Isoelectric point8.12
Molecular weight192512.63
Publications
PubMed=29089032

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP15956
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     130.78|      41|      69|     694|     740|       1
---------------------------------------------------------------------------
  694-  740 (61.95/55.92)	GVANYQNLKVGTLSPKWDRGAgNYSSSIykgviQSGSAGSLAATPGR
  766-  806 (68.83/44.16)	GVGSYTSLDEDQLTVSSNRSA.RLLSPA.....QRVSASSGKASGPR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      80.79|      21|     296|     207|     256|       2
---------------------------------------------------------------------------
  208-  228 (37.65/54.24)	LHMELLVGERSGLMKLDDFRR
 1700- 1720 (43.14/ 8.39)	LGMEGSHGGRACWLRVDDWDR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      46.99|      14|      14|    1198|    1211|       5
---------------------------------------------------------------------------
 1198- 1211 (23.13/11.35)	VPGVTAPISSAAKQ
 1215- 1228 (23.86/11.94)	VPSLPSNVNSSINQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     300.19|      74|     164|    1235|    1308|       6
---------------------------------------------------------------------------
 1235- 1308 (130.33/80.30)	VNPVSATVGTLGTHS.....HPSAAMLAAAGRGGPGIVPSSLLPIDVSVVLRGPY...WIRIIYRKKFAVDMRCFAGDQ..VWL
 1311- 1356 (59.84/32.26)	...........................ATPPKGGPEVGGS..LPCP...QFR.PF...IMEHVAQELNGID..NFTGSQqaVGL
 1391- 1471 (110.02/66.45)	VNGFSRTANGLPAASnlagvNAGMPLRRQPGTGVPAHVRGELNTAIIGLGDDGGYgggWVPLVALKKVLRGILKYLG.V..LWL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      53.47|      15|     164|     388|     402|       7
---------------------------------------------------------------------------
  388-  402 (29.36/19.37)	CCNRYTRLLEI...FKEV
  550-  567 (24.11/14.54)	CGSSYFLLMELdkdFKPV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     112.64|      37|      61|     422|     460|       9
---------------------------------------------------------------------------
  422-  460 (56.18/42.89)	EEVLAD.SRKKDNKFDSreYQGQEVLRVRAFGSSFFTLAI
  485-  522 (56.46/36.58)	EEALNQgSMSAAEAFNS..LRSKSILHLFACIGRFLGLEV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      40.26|      12|      16|    1357|    1368|      13
---------------------------------------------------------------------------
 1357- 1368 (19.94/11.49)	TNSNSINAGSQL
 1373- 1384 (20.32/11.87)	TNRNNLSNSTGL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      49.04|      15|      16|     618|     632|      14
---------------------------------------------------------------------------
  618-  632 (25.62/13.48)	LLSILPSDGRSHQSS
  636-  650 (23.42/11.69)	LLADFSLEGSIVASS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     224.85|      73|     523|     296|     371|      15
---------------------------------------------------------------------------
  296-  371 (117.17/89.30)	SAGSTQTSQDGESESASL.RTPGLK.ILYWLDLDKNIGTSEiGTCPFIKIEPGPDLRIKclHSTFVI.DPLTGKEAEFS
  820-  895 (107.68/70.89)	SATCTKSEQDAASRYNILpRKRTLSdLLDSLPSLKAMQSNE.GSYKRRKLVESAGTHLS..KSPMLIsSDISGKTEEYS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      47.20|      16|     332|     661|     676|      16
---------------------------------------------------------------------------
  655-  673 (22.62/12.09)	FSS.ivdEMFELEKGSSVPS
  674-  693 (24.58/13.87)	FSGqlppSTFGAPPASHFGS
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP15956 with Med14 domain of Kingdom Viridiplantae
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