<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP15954

Description Mediator of RNA polymerase II transcription subunit 12
SequenceMQRYHGGSCTSAVNNNTTGGPSARDSSRVDSASLPPNFSRRPLQLTPYKLKCDKEHLNSRLGPPDFLPQTPNCPEETLTKEYVQFGYRETVEGLEEVKEISLTQLPTFTKPVIFKCKEAIRKCHRAINESRAQKRKAGQVYGVPLEGLQLTKPGIFPEQRSCGEEFRKKWIEGLSQQHKRLKSLADHVPHGYRRKPLFEVLIRNNVPLLRSTWFVKVNYLNQVRPGSSSISSGVSDKTHISRSEQWTKDVIDYLQYLLDEFISKNSVHSALHIRDRSPQMVYAGSIQLKSDPTLGTIDCEEPSLHFKWWYVVRILQWHHREGLLIPSLVIDWVLNQLQEKELLGVLQLLLPVIYGFIDTVVLSQSCVRTLVGIAIRFIQEPSPGGSDLVDNSRRAYTMAALVEMLRYLMLAVPDTFVALDCFPMPSCVMTNVVTDGSLYSKVTEDTRKVKNGPFEVAYFLRDKGPEVRSDSYSIGRVVSSIQKRAQHLAVAARPGHPGQSVVKALHALDKSLALGDLRDAYKFLFENVHESSSDDCWFAEVSSCLRSSLKFIRGVTLSSVCSVFFICEWATCDFRDFRSAPPRGMKFTGRKDFSAIYVAVRLLKLKMREAGISSRRRAPKIVKNDYLRKDPGQLTNYAGRSPASGAAEYLCNSRHAREKCGDSLGMFDSPCPLHDILVCWIDQHAVHNTEGFKRLQLLIVELIRAGIFYPQAYVRQLIVSGIMDGDGPLSDPVKQKRHCKILKHLPGPYVHDALEEARIAESPVLSEVVNVYCNERKLVLRGMIDSYNSVFGSSYHKHKPHPNSGERLAAPSIDQLRSSESGSFPLSKDVGKGVELEELKGSITALLQFPSSSSTDTGVDESQVSLKKGVVYGSNGMDNSEGTPGCEECRRAKKQKLSEEKSSYSQIYPQNPSDDEETWWMRKGQKSIESFRAEPPPKPAKTGSRGRQKIVRKTQSLAQLAAARIEGSQGASTSHVCDSKVSCPHHRPGVEGNVPKSADGTRMPYGDVVSIGKVLKQVRFVDKRTMTVWLIGTVKQLVEEPEKTATKFGQHGRPFSAADERGCVRWKLGEDELSAVLYLIDACDELVLAVRFLLWLLPKVLGSCSATVHGSRNILTIPKNSENSVCEVGEAYLLSSMRRYEGIIVAADLIPETLSVVMHRAQAILTSNGRVPGSPPVIYARYLLKKFGSVGSVTEWEKNVKSTFDKRLVSEVESGRLVDGEFGFPLGVPVGVQDADDYFRQKITGVRVSRVGLSMRDIVQKKVDEAVNYFYGKDRKLFGLNSGKFPGFQKWEDVYQIGQQIVTGLMDCMRQTGGAAQEGDPTLVSSAISAIVCNIGQVIAKIPDLTASNNHLSSSISASLQFARCMLRIHVVCLSILKEALGERQSRVFEVALATETSSALAQLSAPGKAPRSQFQLSPESNDVNLSGDMLNNSSRVAIGRTAKISAAVSALVIGAILQGVSSLERMVSLFRLKDGLDVVHFVRSMRSNSNGNARSVGTLKADSLAEVSVHWFRVLVGNCRTVSDGFVVDLLGEASILSLCRMQRMLSLNLVFPPAYSMFAFVLWRSLILNVSSGTRDEVQHLHHSLMLAFGDVIKHLPFREVCLRDTHSLYDLIAADTVDSDFASLLEASGIDLRSKASAFVPLRARLFLNALIDCRITQPIVKQNDGNQVAVQGESKFHCAENETKLLDKLVCILDTLQPAKFHWQWVELRLLLNEQAVIEKLDAQDLSLVEALRSLSPNTDKASASEIESNIIEMILTRLLVRPDAAPLFAEVVHLLGRSLEDSMLLQAKWFLGGHDVLFGRKSVRQRLSNIAVNRNISTRAQYWKPWGWCTSNSDPITSKREKFKSEVSSIEEGEVVGEGTTLKRPVKGSGRTFDFERLHVSQQHVTERALIDLILPCLDQASDDSRSTFASDMIKQMNHIEQQINTVTREASKPAGTVASGIESPTTKSGRKGTRGSSPGLARRVTGPAETVPPSPVALRASLSVRLQFILRLFPIIYADREPSGRNMRHVLASVILRILGSRVVHEDASYSFNQASSSKREVDSLMEASATASVVISLESLFDHLLLLLHGLLSCHQPRWLKWKSSTKSTSESSKDYSAFDREGAESLQNELDRMQLPETVRWRIQCAMPILSPTARCSISCQPPSVTPSALSSLLPSNPISILHSSNGSNQTQRNPVSLLRTATSVAGKAKQVSSQQENDLEVDPWILLEDGAGSSHSSSNSPLVGGGDHANLKAPNWLKGTVRVRRTDLTYIGAVDDDS
Length2267
PositionKinase
OrganismCapsicum chinense (Scotch bonnet) (Bonnet pepper)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> eudicotyledons> Gunneridae> Pentapetalae> asterids> lamiids> Solanales> Solanaceae> Solanoideae> Capsiceae> Capsicum.
Aromaticity0.07
Grand average of hydropathy-0.239
Instability index47.83
Isoelectric point8.91
Molecular weight250965.02
Publications
PubMed=29089032

Function

Annotated function 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP15954
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     323.23|     100|     108|    1764|    1870|       1
---------------------------------------------------------------------------
 1768- 1870 (159.35/106.96)	DAAPLFAEVVHLLGRSLEDSMLLQAKWFLGGHDVLFGRKSVRQrLSNIAVNRNISTRaQYWKPWGWCTSNSDPITSKREKFKSEVSSIEEG.EVVGEGTTLKrP
 1879- 1979 (163.88/90.23)	DFERLHVSQQHVTERALIDLILPCLDQASDDSRSTFASDMIKQ.MNHIEQQINTVTR.EASKPAGTVASGIESPTTKSGRKGTRGSSPGLArRVTGPAETVP.P
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      54.88|      15|     929|     253|     267|       3
---------------------------------------------------------------------------
  253-  267 (27.43/14.43)	YLQYLLDEFISKNSV
 1179- 1193 (27.45/14.44)	YARYLLKKFGSVGSV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      58.27|      15|     351|     577|     591|       6
---------------------------------------------------------------------------
  577-  591 (29.22/14.31)	FRSAPPRGMKFTGRK
  931-  945 (29.05/14.19)	FRAEPPPKPAKTGSR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     180.64|      57|    1581|     600|     659|       9
---------------------------------------------------------------------------
  600-  659 (88.81/61.62)	VRLLKLKMREAGISSRRRAPKivKNDyLRKDPG.QLTNYAGRSPASGAAEYLCNSRHAREK
 2184- 2241 (91.82/53.65)	VSLLRTATSVAGKAKQVSSQQ..END.LEVDPWiLLEDGAGSSHSSSNSPLVGGGDHANLK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      38.77|      11|     490|     839|     849|      10
---------------------------------------------------------------------------
  839-  849 (19.59/11.15)	LKGSITALLQF
 1352- 1362 (19.18/10.75)	LSSSISASLQF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      55.95|      16|     398|     815|     831|      12
---------------------------------------------------------------------------
  815-  831 (24.89/16.86)	QLRSSESGsFPLSKDVG
 1216- 1231 (31.06/16.97)	RLVDGEFG.FPLGVPVG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     114.48|      36|     836|     472|     508|      16
---------------------------------------------------------------------------
  472-  508 (56.23/42.64)	YSIG.RVVSSIQKRAQHLAVAARPGHPgQSVVKALHAL
 1295- 1331 (58.25/38.89)	YQIGqQIVTGLMDCMRQTGGAAQEGDP.TLVSSAISAI
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP15954 with Med12 domain of Kingdom Viridiplantae
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