<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP15904

Description Mediator of RNA polymerase II transcription subunit 15a
SequenceMDSGDWRTQLLPDSRQRIVNKIMETLKRHLPVSGQEGVQELKKIAVRFEEKIYSAATSQQDYLRKISLKMLTMETKSQNPMTNSVQPNSASSGQNALGPGSNSMQSQVNSQAQQLPGPMVTNQTQTRQPLLQQNIQNNMASTGLQNSASLTPALPPGSNLTHGAMPNVVGQNSNLQNMPNVGQNSVGNAIGQGMPPNMVANSQRQMQGRQQQVASQQQQQFYQQQLHHQMIKQKFQPGNTSQSLMQSHMQQQPQEQQQQQQQPQQQQNLLQPTQTQPSQQAMMQPSSMQSTSLSNLQQNQQSTVQQSTQSVLHQRQQSVMRQQQTPMLHQQQSSMLQQPILPAQQQQQQQLIAQQTNVANLQQNQLIGQQNTMSDVQQRLVGQQNNLNSLQQQQQQQLLNQQNNFQNMHQQQLGSQSNIAGVQQQQLSGSQQPGNSGLTSNQHPIHMMQQPKVPVQQQMLQSSTTVLPSQGQQSQSQPAQQQMMSQSQSQPGQLQPPLGLQQQTNQLQREMQQRLQPSAPFLQQHNAMEQQKQLYQSQRAAPEASSTSLDSTAQTGNANAADWQEEVYQKIKSMKETYLSELNDLYQKIATKVQQHDSLPQRPQNEQIEKLKMFKMTLERIVLFLRLNKHDIQPTHKEKLFSVERHISFFLSSNRPRKPSSSPLQGQLPPSSMQLQQPQSLDGQTNSSMQPVQGSMAGMQQNNLTNLQHNSLSGVPTISNTQQHMINTVQPGSSVDLGQGNSLNSLQQVATGSLQQNPVNSPQQVNISSVSSQSGTNPVQAGLGSLQQNSNTLQQSLPKQHEHQMLQNQQQLRQQYHHRQMQQQIYQRQQLIQQQQAKQQQNALMPTHQLSQLHQMTDPNDLKMRQQMGMKPGVLQQQQSVGQRVGSHHPQLKPGISSPQLHQALSPQLTQHPSPQIDQQNMLASLTKGGTPLQSASSPFVVPSPSTPLAPSPMPGDSEKVCAGLASHTTAGNTMHQQATVASAPAQSLAIGTPGISASPLLAEFTPLDGTHGNVLSTVSGKPNVEQPLERLMKVVKNMSAKALDSSVSDISSVVSMIDRIAGSAPGNGSRAAVGEDLVAMTKCRLQARNYFTQDGPTGTKKMKRYTTSNVVSSSGSLNDRFWQLNCSEAPELESTATSDVKRPRLEVNHALVEEIQDINRKLIDTVVEICDEGVDPSAQTAATEGGEGTTVKCSFTAVALSPNLKALYASAQMSPIQPLRLLVPINYPNCSPILLDKFPVEVSKEYEDLSMKAKSRFSVSLRSLSEPMSLKDIARTWDACARAVISDYSQLSGGGTFSSKYGSWEDCPTTA
Length1312
PositionTail
OrganismCapsicum annuum (Capsicum pepper)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> eudicotyledons> Gunneridae> Pentapetalae> asterids> lamiids> Solanales> Solanaceae> Solanoideae> Capsiceae> Capsicum.
Aromaticity0.03
Grand average of hydropathy-0.778
Instability index69.73
Isoelectric point9.25
Molecular weight144730.42
Publications
PubMed=29089032

Function

Annotated function 
GO - Cellular Component
nucleus	GO:0005634	IEA:UniProtKB-SubCell

GO - Biological Function
chromatin DNA binding	GO:0031490	IBA:GO_Central
transcription coactivator activity	GO:0003713	IEA:InterPro

GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP15904
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             7|     372.30|      45|      45|     341|     385|       1
---------------------------------------------------------------------------
  253-  293 (57.12/11.24)	P...Q.EQQ..Q...QQQQPQQQQ.NL..LQPTQTQP....SQ.QA.M....M.....QPS..SMQST.........sL
  294-  341 (45.92/ 7.39)	S...N.LQQ..N...QQSTVQQSTqSVLHQRQQSVMR....QQ.QTpMLHQ.Q.....QSS..MLQQP.........iL
  342-  387 (75.07/17.43)	P...A.QQQ..Q...QQQLIAQQT.NVANLQQNQLIG....QQ.NT.MSDV.Q.....QRL..VGQQN.........nL
  388-  443 (51.50/ 9.31)	N...SlQQQ..Q...QQQLLNQQN.NFQNMHQQQL.G....SQ.SN.IAGVqQ.....QQL..SGSQQpgnsgltsnqH
  444-  486 (43.69/ 6.61)	PihmM.QQP..KvpvQQQMLQSST.TVLPSQ.....G....QQ.SQ.SQPA.Q.....QQM..MSQ.............
  659-  704 (51.39/ 9.27)	P...S.SSP..L...QGQLPPS...SMQLQQPQSLDG....QT.NSsMQPV.Q.....GSMagMQQNN..........L
  820-  874 (47.62/ 7.97)	Q...M.QQQiyQ...RQQLIQQQQ...AKQQQNALMPthqlSQlHQ.MTDP.NdlkmrQQM..GMKPG..........V
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     167.47|      35|      37|     122|     156|       2
---------------------------------------------------------------------------
   74-   99 (35.40/ 8.82)	.ETKSQ.....NP.M.TNSVQ.PNSASSG.QN........ALGP
  122-  156 (61.43/22.05)	NQTQTR.....QP.LLQQNIQ.NNMASTGLQNS..ASLTPALPP
  159-  196 (39.75/11.03)	NLTHGA.....MPnVVGQNSNlQNMPNVG.QNSvgNAIGQGMPP
  736-  798 (30.89/ 6.53)	DLGQGNslnslQQ.VATGSLQ.QNPVNSPQQNS..NTLQQSLP.
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      63.69|      14|      16|     982|     995|       4
---------------------------------------------------------------------------
  936-  946 (19.21/ 8.69)	AS...SP...FVVPSPS
  982-  995 (26.21/14.82)	AS...APAQSLAIGTPG
  998- 1013 (18.26/ 7.86)	ASpllAEFTPLD.GTHG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     165.94|      59|     109|    1020|    1088|       6
---------------------------------------------------------------------------
 1020- 1088 (81.71/93.31)	SGKPNveqplERLMKVvkNMS.AKALDSS.VSD.......................ISSVVSMIDRiaGSAPGNGSRAAVGEDLVAMtKCRLQA
 1115- 1198 (84.22/63.62)	SGSLN.....DRFWQL..NCSeAPELESTaTSDvkrprlevnhalveeiqdinrklIDTVVEICDE..GVDPSAQTAATEGGEGTTV.KCSFTA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      55.80|      16|     110|     105|     120|       7
---------------------------------------------------------------------------
  105-  120 (26.41/ 6.93)	QSQVNSQAQQLPGPMV
  210-  225 (29.39/ 8.71)	QQQVASQQQQQFYQQQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      43.31|      13|     110|     595|     607|       8
---------------------------------------------------------------------------
  524-  536 (21.00/ 6.61)	QHNAMEQQKQLYQ
  595-  607 (22.30/ 7.64)	QHDSLPQRPQNEQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      53.44|      18|      24|     610|     629|      12
---------------------------------------------------------------------------
  610-  629 (26.38/28.92)	KLKMFkmTLER.IVLFLRLNK
  637-  655 (27.05/20.67)	KEKLF..SVERhISFFLSSNR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      72.14|      22|      37|     909|     931|      13
---------------------------------------------------------------------------
  909-  931 (36.53/20.13)	LTQHPSPQiDQQNMLASL....TKGGT
  949-  974 (35.60/15.68)	LAPSPMPG.DSEKVCAGLashtTAGNT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      62.52|      19|      19|    1239|    1257|      15
---------------------------------------------------------------------------
 1239- 1257 (31.72/22.89)	FPVEVSKEYEDLSMKAKSR
 1258- 1276 (30.80/21.99)	FSVSLRSLSEPMSLKDIAR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      51.91|      15|      19|     488|     502|      16
---------------------------------------------------------------------------
  488-  502 (28.39/14.25)	QSQPGQ.LQPPLGLQQ
  508-  523 (23.52/10.02)	QREMQQrLQPSAPFLQ
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP15904 with Med15 domain of Kingdom Viridiplantae


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) KISLKMLTMETKSQNPMTNSVQPNSASSGQNALGPGSNSMQSQVNSQAQQLPGPMVTNQTQTRQPLLQQNIQNNMASTGLQNSASLTPALPPGSNLTHGAMPNVVGQNSNLQNMPNVGQNSVGNAIGQGMPPNMVANSQRQMQGRQQQVASQQQQQFYQQQLHHQMIKQKFQPGNTSQSLMQSHMQQQPQEQQQQQQQPQQQQNLLQPTQTQPSQQAMMQPSSMQSTSLSNLQQNQQSTVQQSTQSVLHQRQQSVMRQQQTPMLHQQQSSMLQQPILPAQQQQQQ
2) LSSNRPRKPSSSPLQGQLPPSSMQLQQPQSLDGQTNSSMQPVQGSMAGMQQNNLTNLQHNSLSGVPTISNTQQHMINTVQPGSSVDLGQGNSLNSLQQVATGSLQQNPVNSPQQVNISSVSSQSGTNPVQAGLGSLQQNSNTLQQSLPKQHEHQMLQNQQQLRQQYHHRQMQQQIYQRQQLIQQQQAKQQQNALMPTHQLSQLHQMTDPNDLKMRQQMGMKPGVLQQQQSVGQRVGSHHPQLKPGISSPQLHQALSPQLTQHPSPQIDQQNMLASLTKGGTPLQSASSPFVVPSPSTPLAPSPMPGDSEKVCAGLASHTTAGNTMHQQATVASAPAQSL
3) QQQQQQQLLNQQNNFQNMHQQQLGSQSNIAGVQQQQLSGSQQPGNSGLTSNQHPIHMMQQPKVPVQQQMLQSSTTVLPSQGQQSQSQPAQQQMMSQSQSQPGQLQPPLGLQQQTNQLQREMQQRLQPSAPFLQQHNAMEQQKQLYQSQRAAPEASSTSLDSTAQTGNANAADWQEE
65
651
391
349
989
566










Molecular Recognition Features






MoRF SequenceStartStop




NANANA