<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP15895

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMWTNVFKIGGLHQISWFQFLPHESDVNSLVDKRVKLDKKDAATFLVLSSHLQLQKERFLSTWTNSFVGPWDPSQGLYNPDEKIKLWLFLPGQHSSVVEKAQSAVSKLRVLASGLWVAPGDSEELAAALSQALRNCMERTLRGHSYVRYGDVFTKYRPFSQSEELFRKGQPVVEFIFAATEEAIFVHVIISAKHIRALSSGDIDRISENASNVSGEGLPVIVSPHGMRGRLTGCCPGDLVKQVYLSSGKFSASNGIVGLPCNVSQSGYQLKGQNCYVEVSFGCTAPGNNNIQESSNVQNNSSRPIKTEASAMANVVQSKIPDNCGRMLIYPPEAVLVPVVQTACARSSLKRFWLQNWIGPSLSFTSSFMHCFDYHSDAKVNSMDGSWLDANVIGSNRRYNSSSNSNCSSLSSTSTSSSDSDYKTSGTGDLEADADSLMCRQSGLSSLDRSQNDNLKTGFKRSRTGISESFSQGGAVGGAVVNPSTSDYASMEVNNSAITGGNDQLGLQWGWDDDDRDVGMDIQALLSEFGDFGDFFENDALPFGEPPGTAESQTLMIPASDSVDVGSSPCPSMMDVQDQLLLPVGFSSFESFNQPPPPAILDDSLSKHQEVIKSAAVANQVNSTTASIAGEFDHLIKAEALMSFAPEYGAVETPTGENSRLIFRNPYVPKSREVETANSSSNSYVYSATPPLSPCFDACEEKSGVTVNLKAGSARHDTGSIIQSKKYYTHIESGKEKNDDKLSGYVRSCASHETQVAQSPFSGFNSTNSVKGIHNKTDKANEGLLKAGSSSQSIKTVLATEVECLMCQAFMCKIRHTLLSSSGCLPVGMSRMSGSTSRNQSQGEAVVTGDNLSIKSEMKKKEIIPVRIAGDIDGGLLDGTLNAPVGVWRSVGVSKGMKQPTAGLESGHSVQHNSFIEDSMLAYGLRQPLQELLDGMALLVQQATSLVDVALDADSNDGSFGWLALQEQWRRGFSCRPSMVHAGCGGVLASCHSLDIAGVELIDPLSADVPASFTLTLLQNDIKAALKSAFGNMEGPLSVVDWCKGRSQSNDGGISGDGFSAESTASASECRDSSSTISLSVGEPISPSQSSAGGSSSLRDGIRVDEASERRLSQDTCLSESENLLGSRLRPTLAAVPYPAILLGYQDDWLKTSPSSLQIWEKAPFEPYAMPKNMTYYVVCPDINALTTAATDFFQQLGTVYETCKLGTHSPQCMGNEMEIDSGKNASSGFVLIDCPQSMKIDSSNASMLGSISDYFLALSNGWDLESYLKSLSKVLRNLKLSSCLTMNPKEGSTAPCTVIYVVCPFPEPLAVLQTVIESSIAVGSVVLSSDKERRSTLHNQVGKALSYSAAVDEALSNVLTLSGFCIPKLVLQIVTVDAIFRVTSPALSELVILKEIAFTVYNKARRISRGSSSDMVQSSSMSGRSHPVMMQMTSQVPGMWKDCVGPRGIGTSLQRETDLDASLRPGSWDNWQTSRGGGLGCEPNRIRDFSFQDEIRYLFEPLYILAEPGSLDRGLSFPISGNPMTESSKLLSDDGTSGSFMQSSASSGGGDTGLNTQSETSEPDGFGSARQRSLPSLHCCYDWTEDWRWLVCIWTDSRGELLDNHIYPFGGISSRQDTKGLQSLFVQILQQGCQILQACSPEAANAKPRDFVIARVGSFLELECQEWQKALYSIGGSEVKKWSLQLRRSVPDGMTASSNGTSLPQQEIGGLSQPSTRKQLIGGQGIADNSRGLLQWVQSISFVSLSVDHSLQLVVQAESTSLGTSQSSGIMSQPGYLEGYTPVKSLGSTPTSYILIPSPNMRFLPPIGLQLPTCLTAESPPLAHLLHSKGCVIPLSTGFVVSKAVPTMRRDARSISKEEWPSILSVSLVDYYGGSNIIQEKFLKGVVKTGGRGTGSEARDVETATHLILENIAAELHALSWMTVSPAYLERRSALPFHCDTVLRLRRLLHFADKEVSRQPEKSQV
Length1965
PositionKinase
OrganismCapsicum annuum (Capsicum pepper)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> eudicotyledons> Gunneridae> Pentapetalae> asterids> lamiids> Solanales> Solanaceae> Solanoideae> Capsiceae> Capsicum.
Aromaticity0.07
Grand average of hydropathy-0.224
Instability index53.19
Isoelectric point5.44
Molecular weight212106.30
Publications
PubMed=29089032

Function

Annotated function Component of the Mediator complex, a coactivator involved in regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IBA:GO_Central

GO - Biological Function
transcription coregulator activity	GO:0003712	IBA:GO_Central

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IBA:GO_Central









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP15895
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     129.45|      40|     259|     416|     464|       1
---------------------------------------------------------------------------
  416-  464 (60.32/49.51)	SSDSDYKTSGTGDLEADADSlmC.RQSGLSSldrsqndNLKTGFKRSRTG
  678-  718 (69.13/37.28)	SSSNSYVYSATPPLSPCFDA..CeEKSGVTV.......NLKAGSARHDTG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      43.40|      12|      30|    1113|    1124|       2
---------------------------------------------------------------------------
 1113- 1124 (20.96/12.45)	QDTCLSESENLL
 1145- 1156 (22.44/13.95)	QDDWLKTSPSSL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      62.25|      14|      25|    1437|    1450|       3
---------------------------------------------------------------------------
 1437- 1450 (31.23/19.58)	PGMWKDCVGPRGIG
 1465- 1478 (31.02/19.39)	PGSWDNWQTSRGGG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     104.62|      30|     121|     523|     553|       4
---------------------------------------------------------------------------
  524-  553 (55.95/35.05)	LLSEFGDFGDFFENDALPFGEPPG.TAESQT
 1530- 1560 (48.68/24.96)	LLSDDGTSGSFMQSSASSGGGDTGlNTQSET
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      67.43|      17|     121|    1163|    1180|       5
---------------------------------------------------------------------------
 1163- 1180 (32.89/23.32)	PFEPYAMPKNMtYYVVCP
 1288- 1304 (34.54/19.86)	PKEGSTAPCTV.IYVVCP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      30.33|       9|      18|    1217|    1226|       6
---------------------------------------------------------------------------
 1217- 1226 (13.00/12.84)	MEIDSgKNAS
 1238- 1246 (17.33/10.28)	MKIDS.SNAS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      63.52|      18|     121|     759|     791|       9
---------------------------------------------------------------------------
  759-  776 (31.63/ 7.60)	PFSGFNSTNSVKGIHNKT
  883-  900 (31.89/ 7.80)	PVGVWRSVGVSKGMKQPT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     248.42|      79|     816|     909|    1071|      10
---------------------------------------------------------------------------
  987- 1071 (114.43/191.67)	LAscHSLDIAGVelIDPLSADVPASFTLTLLQNDIKAALKSAFGNMEGpLSVVDWCKGRSQSNDGGISGdGFSAESTASASECRD
 1822- 1900 (134.00/57.97)	LA..HLLHSKGC..VIPLSTGFVVSKAVPTMRRDARSISKEEWPSILS.VSLVDYYGGSNIIQEKFLKG.VVKTGGRGTGSEARD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      45.26|      12|      32|     347|     358|      13
---------------------------------------------------------------------------
  347-  358 (25.51/13.39)	SLKRFWLQ.NWIG
  381-  393 (19.75/ 8.74)	SMDGSWLDaNVIG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      53.80|      15|     127|    1561|    1575|      15
---------------------------------------------------------------------------
 1561- 1575 (29.35/17.90)	SEPDGF.GSARQRSLP
 1689- 1704 (24.45/13.41)	SVPDGMtASSNGTSLP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     143.37|      45|    1697|       7|      53|      24
---------------------------------------------------------------------------
    7-   53 (74.00/51.50)	KIGGLHQISWFQFLPHESDVNSlvDKRVKLDKKDAATFLVLS.SH.LQL
 1707- 1753 (69.37/42.47)	EIGGLSQPSTRKQLIGGQGIAD..NSRGLLQWVQSISFVSLSvDHsLQL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      34.52|      10|      23|    1482|    1491|      26
---------------------------------------------------------------------------
 1482- 1491 (19.93/11.72)	EPNRI.RDFSF
 1507- 1517 (14.59/ 6.32)	EPGSLdRGLSF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      87.25|      24|      39|     209|     233|      27
---------------------------------------------------------------------------
  209-  233 (41.28/26.02)	ASNvSGEGLPVIVSPHGMRGRLTGC
  251-  274 (45.97/25.14)	ASN.GIVGLPCNVSQSGYQLKGQNC
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP15895 with Med13 domain of Kingdom Viridiplantae
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