<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP15886

Description Mediator of RNA polymerase II transcription subunit 14 (Fragment)
SequenceMAELGQQTVDFSALVSRAAEESYVTLKELVEKCKSSDLSDSEKKIGILKYVVKTQQRMLRLNVLSKWCQQVPLIQYCQQLASTLSSHDTCFTQAADSLFFMHEGLQQARAPIYDVPSAVEVLLTGSYGRLPKCIGDLGLQSSLNDDQQKPALKKLDALVRSKLLEVSLPKDITEVKVSDGTVLLRVDGEFKVLVTLGYRGHLSMWRILHMELLVGERSGPMKLDDFRRHALGDDLERRMAAADNPFMTLYSILHELCVALVMDTVIRQVQTLRQGRWKDAIRFELITDGSTGQGSSAGSTQTSQDGESESASLRTPGLKILYWLDLDKNIGTSEIGTCPFIKIEPGPDLQIKCLHSTFVIDPLTGKEAEFSLDQSCIDIEKLLLRVICCNRYTRLLEIFKEVEKNGQICRVPGDVQLQCHVEEVLADSRKKDNKFDSREYQGQEVLRVRAFGSSFFTLAINIRNGHFILHSSKNVISSSVVVECEEALNQGSMSAAEAFNSLRSKSILHLFACIGRFLGLEVFEHGSASVKVPKSISCGTNFLLMGFPECGSSYFLLMELDKDFKPVFKLLESQSDSPAKAQPLADLSNMVRVKTIDVGRMQICEDKLNLSLLNSKKLLSILPSDGRSHQSSENSLLADFSLEGSIVASSAPSAFSSIVDEMFELEKGSSVPSFSGQLPPSTFGAPPASHFGSGVANYQNLKVGTLSPKWDRGAGNYSSSIYKGVIQSGSAARLLSPAQRVSASSGKASGPRNSAVGTLPAQAIDSATCTKSEQDAASRYNILPRKRTLSDLLDSLPSLKAMQSNEGSYKRRKLVESAGTHLSKSPMLISSDISGKTEEYSYGSLIAEANKGNAPSSIYVSALLHVVRHCSLCIKHARLTSQMEELDIPYVEEVGLRSASSNLWFRVPFARDDGWQHICLRLGRPGSMYWDVKINDQHFQDLWELQKGSNSTPWGSGVRIANTSDADSHIRYDCEGVVLSYYSVNADSIKKLVADIQRLSNARTFAFGMRKLLGARADEKFEENNVNSESKTSVAIKGSADATDRISEQMRKQFRIEAVGLMSLWFSFGSGVLARFVVEWESGKEGCTMHVSPDQLWPHTKFLEDFINGAEVASLLDCIRLTAGPLHALAAATRPARAAPVSGVPGVTAPISSVAKQASYVPSLPSNVNSSINQPASGPGVNPVSATVGTLGTHSHPSAA
Length1200
PositionTail
OrganismCapsicum annuum (Capsicum pepper)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> eudicotyledons> Gunneridae> Pentapetalae> asterids> lamiids> Solanales> Solanaceae> Solanoideae> Capsiceae> Capsicum.
Aromaticity0.07
Grand average of hydropathy-0.176
Instability index43.82
Isoelectric point6.83
Molecular weight131111.78
Publications
PubMed=29089032

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
core mediator complex	GO:0070847	IBA:GO_Central
mediator complex	GO:0016592	IBA:GO_Central

GO - Biological Function
transcription coregulator activity	GO:0003712	IBA:GO_Central

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IBA:GO_Central









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP15886
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     428.40|     147|     469|     296|     526|       1
---------------------------------------------------------------------------
  209-  388 (220.73/219.98)	HM.ELLVGERSGPMKLDDfrRHALGDDLeRRMAAADNPFMTL.......YSILHELCVALVMDTVIRQVQTLRQGRWKDAIRFELITDGS.tgqgssagstqtsqdgeseSASLRTP.....GLKILYwldldknIGTSEIGTCPFIKIEPGPDLQ..IKCLHSTfVIDPLTGKE.AEFS..LDQSCIDIEKLLlrvIC
  420-  604 (207.67/166.83)	HVeEVLADSRKKDNKFDS..REYQGQEV.LRVRAFGSSFFTLainirngHFILHSSKNVISSSVVVECEEALNQGSMSAAEAFNSLRSKSilhlfacigrflglevfehgSASVKVPksiscGTNFLL.......MGFPECGSSYFLLMELDKDFKpvFKLLESQ.SDSPAKAQPlADLSnmVRVKTIDVGRMQ...IC
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     217.63|      68|    1026|      90|     159|       3
---------------------------------------------------------------------------
   90-  159 (112.18/74.26)	CFTQAADSLFFMHEGLQQAR.APIYDVPSAVEVLltGSYGRLPKCIGDL..GLQSSLNDDQQKPALKKLDALV
 1118- 1188 (105.45/64.21)	CIRLTAGPLHALAAATRPARaAPVSGVPGVTAPI..SSVAKQASYVPSLpsNVNSSINQPASGPGVNPVSATV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     142.41|      46|     207|     612|     659|       4
---------------------------------------------------------------------------
  612-  659 (65.78/41.25)	LLNSKKLLSILPSdGRSHQSSENSLLADFSlEGSIVASSAPSAFSSIV
  822-  867 (76.63/40.34)	LSKSPMLISSDIS.GKTEEYSYGSLIAEAN.KGNAPSSIYVSALLHVV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      60.19|      16|     278|     661|     676|       5
---------------------------------------------------------------------------
  661-  676 (30.72/22.74)	EMFELEKGS.SVPSFSG
  941-  957 (29.47/21.43)	DLWELQKGSnSTPWGSG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     141.24|      45|     718|     161|     207|       7
---------------------------------------------------------------------------
  161-  207 (67.01/52.61)	SKLLEVSLPKdITEV..KVSDGTVLLRV.....DGEFKVLVTLGYRGHLsMWRI
  881-  932 (74.23/48.64)	SQMEELDIPY.VEEVglRSASSNLWFRVpfardDGWQHICLRLGRPGSM.YWDV
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP15886 with Med14 domain of Kingdom Viridiplantae
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