<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP15884

Description Mediator of RNA polymerase II transcription subunit 12
SequenceMQRYHGGSCTSAVNNNTTGGPSARDSSRVDSASLPPNFSRRPLQLTPYKLKCDKEHLNSRLGPPDFLPQTPNCPEETLTKEYVQFGYRETVEGLEEVKEISLTQVPTFTKPVIFKCKEAIRKCHRAINESRAQKRKAGQVYGVPLEGLQLTKPGIFPEQRSCGEEFRKKWIEGLSQQHKRLKSLADHVPHGYRRKPLFEVLIRNNVPLLRSTWFVKVNYLNQVRPGSSSISSGVSDKTHISRSEQWTKDVIDYLQYLLDEFISKNSVHSALHIRDRSPQMVYAGSIQLKSDPTLGTIDCEEPSLHFKWWYVVRILQWHHREGLLIPSLVIDWVLNQLQEKELLGVLQLLLPVIYGFIDTVVLSQSCVRTLVGIAIRFIQEPSPGGSDLVDNSRRAYTMAALVEMLRYLMLAVPDTFVALDCFPMPSCVMTNVVTDGSLYSKVTEDTRKVKNGPFEVAYFLRDKGPEVRSDSYSIGRVVSSIQKRAQHLAVAARPGHPGQSVVKALHALDKSLALGDLRDAYKFLFENVHESSSDDCWFAEVSSCLRSSLKFIRGVTLSSVCSVFFICEWATCDFRDFRSAPPRGMKFTGRKDFSAIYVAVRLLKLKMREAGISSRRRAPKIVKNDYLRKDPGQLTNYAGRSPASGAAESLCNSRHAREKCGDSLGMFDSPCPLHDILVCWIDQHAVHNTEGFKRLQLLIVELIRAGIFYPQAYVRQLIVSGIMDGDGPLSDPVKQKRHCKILKHLPGPYVHDALEEARIAESPVLSEVVNVYCNERKLVLRGMIDSYNSVFGSSYHKHKPRPNSGERLAAPSIDQLRSSESGSFPLSKDVGKGVELEELKGSITALLQFPSSSSTDTGVDESQVSLKKGVVYGSNGMDNSEGTPGCEECRRAKKQKLSEEKSSYSQIYPQNPSDDEETWWMRKGQKSIESFRAEPPPKPAKTGSRGRQKIVRKTQSLAQLAAARIEGSQGASTSHVCDSKVSCPHHRPGVEGNVPKSADGTRMPYGDVVSIGKVLKQVRFVDKRTMTVWLIGTVKQLVEEPEKTATKVGQHGRPFSAADERGCVRWKLGEDELSAVLYLIDACDELVLAVRFLLWLLPKVLGSCSATVHGSRNILTIPKNSENSVCEVGEAYLLSSMRRYEGIIVAADLIPETLSVVMHRAQAILTSNGRVPGSPPVIYARYLLKKFGSVGSVTEWEKNVKSTFDKRLVSEVESGRLVDGEFGFPLGVPVGVQDADDYFRQKITGVRVSRVGLSMRDIVQKKVDEAVNYFYGKDRKLFGLNSGKFPGFQKWEDVYQIGQQIVTGLMDCMRQTGGAAQEGDPTLVSSAISAIVCNVGQVIAKIPDLTASNNHLSSSISASLQFARCMLRIHVVCLSILKEALGERQSRVFEVALATETSSALAQLSAPGKAPRSQFQLSPESNDVNLSSDMLNNSSRVAIGRTAKISAAVSALVIGAILQGVSSLERMVSLFRLKDGLDVVHFVRSMRSNSNGNARSVGTLKADSLAEVSVHWFRVLVGNCRTVSDGFVVDLLGEASILSLCRMQRMLSLNLVFPPAYSMFAFVLWRSLILNVSSGTRDEVQHLHHSLMLAFGDVIKHLPFREVCLRDTHSLYDLIAADTVDSDFASLLEASGIDLRSKASAFVPLRARLFLNALIDCRITQPIVKQNDGNQVAVQGESKFHCAENETKLLDKLVCILDTLQPAKFHWQWVELRLLLNEQAVIEKLDAQDLSLVEALRSLSPNTDKASASEIESNIIEMILTRLLVRPDAAPLFAEVVHLLGRSLEDSMLLQAKWFLGGHDVLFGRKSVRQRLSNIAVNRNISTRAQYWKPWGWCTSNSDPITSKREKFKSEVSSIEEGEVVGEGTTLKRPVKGSGRTFDFERLHVSQQHVTERALIDLILPCLDQASDDSRSTFASDMIKQMNHIEQQINTVTREASKPAGTVASGIESPTTKSGRKGTRGSSPGLARRVTGPAETVPPSPVALRASLSVRLQFILRLFPIIYADREPSGRNMRHVLASVILRILGSRVVHEDASYSFNQASSSKREVDSLMEASATASVVISLESLFDHLLLLLHGLLSCHQPRWLKWKSSTKSTSESSKDYSAFDREGAESLQNELDRMQLPETVRWRIQCAMPILSPTARCSISCQPPSVTPSALSSLLPSNPISILHSSNGSNQTQRNPVSLLRTATSVAGKAKQVSSQQENDLEVDPWILLEDGAGSSHSSSNSPLVGGGDHANLKAPNWLKGTVRVRRTDLTYIGAVDDDS
Length2267
PositionKinase
OrganismCapsicum annuum (Capsicum pepper)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> eudicotyledons> Gunneridae> Pentapetalae> asterids> lamiids> Solanales> Solanaceae> Solanoideae> Capsiceae> Capsicum.
Aromaticity0.07
Grand average of hydropathy-0.239
Instability index47.73
Isoelectric point8.93
Molecular weight250861.90
Publications
PubMed=29089032

Function

Annotated function 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of development, heterochronic	GO:0040034	IEA:EnsemblPlants
regulation of radial pattern formation	GO:0090213	IEA:EnsemblPlants
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP15884
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     114.92|      40|     291|    1442|    1486|       1
---------------------------------------------------------------------------
 1442- 1486 (58.48/52.13)	TAKISAA.VSALVIGAILQGVSSLERMVSLFrlkdgLDVVHFV.RSM
 1743- 1784 (56.45/37.95)	TDKASASeIESNIIEMILTRLLVRPDAAPLF.....AEVVHLLgRSL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      54.88|      15|     929|     253|     267|       2
---------------------------------------------------------------------------
  253-  267 (27.43/17.59)	YLQYLLDEFISKNSV
 1179- 1193 (27.45/17.60)	YARYLLKKFGSVGSV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     309.68|      99|     108|    1809|    1916|       6
---------------------------------------------------------------------------
 1809- 1916 (147.51/112.81)	RQrLSNIAVNRNISTRaQYWKPWGWCTSNSDPITSKREKFKSEVSSIEEG.EVVGEGTTLKrPVKGSGRTfdfeRLHVSQQHVTEraLIDLILPCLDQASDDSRSTFAS
 1920- 2019 (162.17/96.14)	KQ.MNHIEQQINTVTR.EASKPAGTVASGIESPTTKSGRKGTRGSSPGLArRVTGPAETVP.PSPVALRA....SLSVRLQFILR..LFPIIYADREPSGRNMRHVLAS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      66.03|      20|     844|     542|     561|      18
---------------------------------------------------------------------------
  542-  561 (35.33/21.07)	SSCLRSSLKFIR.GVTLSSVC
 1353- 1373 (30.70/17.32)	SSSISASLQFARcMLRIHVVC
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      55.95|      16|     399|     815|     831|      23
---------------------------------------------------------------------------
  815-  831 (24.89/17.61)	QLRSSESGsFPLSKDVG
 1216- 1231 (31.06/17.72)	RLVDGEFG.FPLGVPVG
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP15884 with Med12 domain of Kingdom Viridiplantae


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) IEQQINTVTREASKPAGTVASGIESPTTKSGRKGTRGSSPGLARRVTGPAETVP
2) LSEEKSSYSQIYPQNPSDDEETWWMRKGQKSIESFRAEPPPKPAKTGSRGRQKIVRKTQSLAQLAAARI
3) PSSSSTDTGVDESQVSLKKGVVYGSNGMDNSEGTPGCEECRRAKKQ
4) YHGGSCTSAVNNNTTGGPSARDSSRVDSASLPPNF
1925
897
850
4
1978
965
895
38










Molecular Recognition Features






MoRF SequenceStartStop




NANANA