<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP15878

Description Multifunctional fusion protein
SequenceMVMGNPPLAFEFELAQVSVNHRDCDDASIATSMIMAGVPLTEPYLWCYLSSLAKEERNGLESGRLPISDTFYLMGTSRLTDTLNPQEVFVVLEHGQIYGEVLAYRNPGLQFGDIHRLLAVPVKNLGDIIGNAKYEKSDASELPQEYLGILLHEQPNKYYMVIRGQRLIMEAESSMQTIMEKLQSHQLRVGFKFEGFQYQLGEFRLRVGKVVPFGSESLRGIVMEMEYLPISSVEISQLIMSELFDIWKEALEKRSLPGHFVRVEPKFSEYGLSDQYTSQHTAVQYADSLAHMIKLRDSLSLNLLERIELRFVVHIGGLSETASLLLPSRGSIGNNLATSFESAPSSTSSASRARMLVMHLQLLDSEKTVA
Length370
PositionHead
OrganismCapsicum annuum (Capsicum pepper)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> eudicotyledons> Gunneridae> Pentapetalae> asterids> lamiids> Solanales> Solanaceae> Solanoideae> Capsiceae> Capsicum.
Aromaticity0.08
Grand average of hydropathy-0.089
Instability index46.39
Isoelectric point5.37
Molecular weight41562.22
Publications
PubMed=29089032

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Probably involved in the RNA silencing pathway and required for the generation of small interfering RNAs (siRNAs). 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
nuclear RNA-directed RNA polymerase complex	GO:0031380	IBA:GO_Central

GO - Biological Function
RNA binding	GO:0003723	IEA:UniProtKB-KW
RNA-directed 5'-3' RNA polymerase activity	GO:0003968	IBA:GO_Central
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
production of siRNA involved in chromatin silencing by small RNA	GO:0070919	IBA:GO_Central
production of siRNA involved in RNA interference	GO:0030422	IBA:GO_Central
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP15878
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      47.66|      14|      15|     182|     196|       1
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  182-  196 (21.92/16.12)	LQSHQLRVGfKFEGF
  200-  213 (25.74/13.90)	LGEFRLRVG.KVVPF
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP15878 with Med20 domain of Kingdom Viridiplantae
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