<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP15838

Description Mediator of RNA polymerase II transcription subunit 15a
SequenceMDGNNWRAAQGGGDGGAAGGAAGTVAGAMDSGDWRTQLLPDSRQRIVNKIMETLKRHLPVSGQEGVQELKKIAVRFEEKIYSAATSQQDYLRKISLKMLTMETKSNPMTNSVQPNSASSGQNALGPGSNSMQSQVNSQAQQLPGPMVTNQTQTRQPLLQQNIQNNMASTGLQNSASLTPALPPGSNLTQGAMPNVVGQNSNLQNMPNVGQNSVGNAIGQGMPPNMVANSQRQMQGRQQQVASQQQQQFYQQQLHHQMMKQKFQPGNTSQSLMQSHMQQQPQEQQQQQQPQQQQNLLQPTQTQPSQPAMMQPSSMQSTSLSNLQQNQQSTVQQSTQSVLHQRQQSVMRQQQTPMLHQQQSSMLQQPILPAQQQQQQQLIAQQTNVANLQQNQLIGQQNTMSDVQQRLVGQQNNLNSLQQQQQQQLLNQQNNFQNMHQQQLGSQSNIAGVQQQQLSGSQQPGNSGLTSNQHPIHMMQQPKVPVQQQMLQSSTTVLPSQGQQSQSQPAQQQMMSQSQSQPGQLQPPLGLQQQTNQLQREMQQRLQPSAPFLQQHNAMEQQKQLYQSQRAAPEASSTSLDSTAQTGNANAADWQEEVYQKIKSMKETYLSELNDLYQKIATKVQQHESLPQRPQNEQIEKLKMFKMTLERIVLFLRLNKHDIQPTHKEKLFSVERHISFFLSSNRPRKPSSSPLQGQLPPSSMQLQQPQSLDGQTNSSMQPVQGSMAGMQQNNLTNLQHNSLSGVPTISNTQQHMINTVQPGSSVDLGQGNSLNSLQQVATGSLQQNPVNSPQQANISSVSSQSGTNPVQAGLGSLQQNSNTLQQSLPKQHEHQMLQNQQQLRQQYHHRQMQQQLYQRQQLMQQQQAKQQQTALMPTHQLSQLHQMTDPNDLKMRQQMGMKPGVLQQQQSVGQRVGSHHPQLKPGISSPQLHQALSPQLTQHPSPQIDQQNMLASLTKGGTPLQSASSPFVVPSPSTPLAPSPMPGDSEKVCAGLASHTTAGNTMHQQATVASAPAQSLAIGTPGISASPLLAEFTPLDGTHGNVLSTVSGKSNVEQPLERLMKVVKNMSAKALDSSVSDISSVVSMIDRIAGSAPGNGSRAAVGEDLVAMTKCRLQARNYFTQDGPTGTKKMKRYTTSNVVSSSGSLNDRFWQLNCSEAPELESTATSDVKRPRLEVNHALVEEIQDINRKLIDTVVEICDEGVDPSAQTAATEGGEGTTVKCSFTAVALSPNLKALYASAQMSPIQPLRLLVPINYPNCSPILLDKFPVEVSKEYEDLSMKAKSRFSVSLRSLSEPMSLKDIARTWDACARAVISDYSQLSGGGTFSSKYGSWEDCPTTA
Length1338
PositionTail
OrganismCapsicum baccatum (Peruvian pepper)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> eudicotyledons> Gunneridae> Pentapetalae> asterids> lamiids> Solanales> Solanaceae> Solanoideae> Capsiceae> Capsicum.
Aromaticity0.03
Grand average of hydropathy-0.766
Instability index68.52
Isoelectric point9.21
Molecular weight146832.63
Publications
PubMed=29089032

Function

Annotated function 
GO - Cellular Component
nucleus	GO:0005634	IEA:UniProtKB-SubCell

GO - Biological Function
chromatin DNA binding	GO:0031490	IEA:InterPro
transcription coactivator activity	GO:0003713	IEA:InterPro

GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP15838
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             8|     389.64|      45|      45|     367|     411|       1
---------------------------------------------------------------------------
  196-  248 (38.10/ 6.06)	VGQN.............SN.LQNM.PN..V...........GQNSvgnaigqgMPpnmvA.NSQ....RQMQ..GRQQQVASQQQQQF
  249-  301 (53.78/12.41)	YQQQlhhqmmkqkfqpgNT.SQSL.MQSHM...........QQQ..........P....Q.EQQ....QQQQ.PQQQQNL..LQPTQT
  346-  392 (64.71/16.83)	MRQQ.............QTpMLHQ.QQSSM...........LQQP.......iLP....A.QQQ....QQQQLIAQQTNVANLQQNQL
  393-  439 (68.06/18.19)	IGQQ.............NT.MSDV.QQRLV...........GQQN.......nLN....SlQQQ....QQQQLLNQQNNFQNMHQQQL
  440-  479 (39.77/ 6.74)	.GSQ.............SN.IAGVqQQQLS...........GSQ..................QP....GNSGLTSNQHPIHMMQQPKV
  739-  793 (38.45/ 6.20)	SGVP..............T.ISNT.QQHMIntvqpgssvdlGQGN.......sLN....S.LQQ....VATGSL.QQNPVNSPQQANI
  796-  851 (42.51/ 7.85)	VSSQ.............SG.TNPV.QAGLG...........SLQQnsntlqqsLP....K.QHEhqmlQNQQQLRQQYHHRQMQQ.QL
  852-  893 (44.27/ 8.56)	YQRQ.............QL.MQ...QQQAK...........QQQT......alMP....T.HQL....SQ...LHQMTDPNDLKMRQQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     209.92|      52|      55|     935|     987|       2
---------------------------------------------------------------------------
  935-  978 (69.16/32.51)	................LTQHPSP..QIDQ..QNMLASLTKG....GT.PLQSA....SSPFVVPSPSTPLAPS
  980- 1034 (51.17/23.69)	MPGDSEKV.....cagLASHTTAgnTMHQ..QATVASAPAQslaiGT.PGISA.....SPLL..AEFTPL...
 1035- 1090 (40.70/15.72)	.DGTHGNVlstvsgksNVEQPLE..RLMKvvKNMSAK...........ALDSSvsdiSS...VVSMIDRIAGS
 1091- 1140 (48.90/18.20)	APGNGSRA...avgedLVAMTKC..RLQA..RNYFTQDGPT....GTkKMKRY....TTSNVVSS........
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     166.57|      28|      29|     494|     521|       4
---------------------------------------------------------------------------
  303-  328 (41.48/11.96)	PSQPAMMQPSSMQSTS.L.SNLQQNQQS
  480-  503 (41.11/11.77)	PVQQQMLQSSTT....VLPSQGQQSQSQ
  504-  531 (51.00/16.73)	PAQQQMMSQSQSQPGQLQPPLGLQQQTN
  689-  705 (32.98/ 7.69)	PLQ...........GQLPPSSMQLQQPQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      75.83|      19|      19|      39|      57|       6
---------------------------------------------------------------------------
   48-   66 (32.32/20.27)	NKIMETLKRH..LPVSGQ.EGV
  613-  634 (22.44/11.25)	QKIATKVQQHesLPQRPQnEQI
  635-  648 (21.07/10.00)	EK.LKMFKMT..L....E.RIV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     143.45|      33|     560|     134|     174|       7
---------------------------------------------------------------------------
  134-  174 (47.73/42.19)	QVNSQAQQLpgpmvtnQTQTRQPLLQQNiQNNM.ASTGLQ.NS
  532-  563 (50.28/24.10)	QLQREMQQ........RLQPSAPFLQQ..HNAMeQQKQLY.QS
  710-  737 (45.43/20.71)	QTNSSMQPV.........QGSMAGMQQN...NL...TNLQhNS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      53.73|      16|      16|    1264|    1279|       9
---------------------------------------------------------------------------
 1264- 1279 (27.35/17.52)	KFPVEVSKEYEDLSMK
 1283- 1298 (26.37/16.63)	RFSVSLRSLSEPMSLK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      51.83|      15|      20|     898|     917|      11
---------------------------------------------------------------------------
  898-  917 (23.34/17.13)	PGVlqqqqSVGQRVGSHHPQ
  920-  934 (28.48/10.75)	PGI.....SSPQLHQALSPQ
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP15838 with Med15 domain of Kingdom Viridiplantae


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) ISLKMLTMETKSNPMTNSVQPNSASSGQNALGPGSNSMQSQVNSQAQQLPGPMVTNQTQTRQPLLQQNIQNNMASTGLQNSASLTPALPPGSNLTQGAMPNVVGQNSNLQNMPNVGQNSVGNAIGQGMPPNMVANSQRQMQGRQQQVASQQQQQFYQQQLHHQMMKQKFQPGNTSQSLMQSHMQQQPQEQQQQQQPQQQQNLLQPTQTQPSQPAMMQPSSMQSTSLSNLQQNQQSTVQQSTQSVLHQRQQSVMRQQQTPMLHQQQSSMLQQPILPAQQQQQQ
2) LSSNRPRKPSSSPLQGQLPPSSMQLQQPQSLDGQTNSSMQPVQGSMAGMQQNNLTNLQHNSLSGVPTISNTQQHMINTVQPGSSVDLGQGNSLNSLQQVATGSLQQNPVNSPQQANISSVSSQSGTNPVQAGLGSLQQNSNTLQQSLPKQHEHQMLQNQQQLRQQYHHRQMQQQLYQRQQLMQQQQAKQQQTALMPTHQLSQLHQMTDPNDLKMRQQMGMKPGVLQQQQSVGQRVGSHHPQLKPGISSPQLHQALSPQLTQHPSPQIDQQNMLASLTKGGTPLQSASSPFVVPSPSTPLAPSPMPGDSEKVCAGLASHTTAGNTMHQQATVASAPAQSL
3) QQQQQQQLLNQQNNFQNMHQQQLGSQSNIAGVQQQQLSGSQQPGNSGLTSNQHPIHMMQQPKVPVQQQMLQSSTTVLPSQGQQSQSQPAQQQMMSQSQSQPGQLQPPLGLQQQTNQLQREMQQRLQPSAPFLQQHNAMEQQKQLYQSQRAAPEASSTSLDSTAQTGNANAADWQEE
94
677
417
375
1015
592










Molecular Recognition Features






MoRF SequenceStartStop




NANANA