<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP15795

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMAELGQQTVDFSALVSRAAEESYVTLKELVEKCKSSDLSDSEKKIGILKYVVKTQQRMLRLNVLSKWCQQVPLIQYCQQLASTLSSHDTCFTQAADSLFFMHEGLQQARAPIYDVPSAVEVLLTGSYGRLPKCIGDLGLQSSLNDDQQNPALKKLDALVRSKLLEVSLPKDITEVKVSDGTVLLRVDGEFKVLVTLGYRGHLSMWRILHMELLVGERSGPMKLDDFRRHALGDDLERRMAAADNPFMTLYSILHELCMALVMDTVIRQVQTLRQGRWKDAIRFELITDGSAGQGSSAGSTQTSQDGESESASLRTPGLKILYWLNLDKNIGTSEIGTCPFIKIEPGPDLRIKCLHSTFVIDPLTGKEAEFSLDQSCIDIEKLLLRVICCNRYTRLLEIFKEVEKNGQICRVPGDVQLQCHVEEVLADSRKKDNKFDSREYQGQEVLRVRAFGSSFFTLAINIRNGHFILHSSKNVISSSVVVECEEALNQGSMSAAEAFNSLRSKSILHLFACIGRFLGLEVFEHGSASVKVPKSISCGTNFLLMGFPECGSSYFLLMELDKDFKPVFKLLESQSDSPAKAQPLADLSNMVRVKTIDVGRMQICEDKLNLSLLNSKKLLSILPSDGGSHQSSENSLLADFSLEGSIVASSAPSAFSSIVDEMFELEKGSSVPSFSGQLPPSTFGAPPASHFGSGVANYQNLKVGTLSPKWDRGAGNYSSSIYKGVIQSGSAGSLAATPGRIQTGKKLPASKSEQDLTSLRSPHSAGVGSYTSLDEDQLTVSSNRSARLLSPAQRVSASSGKASGPKNSAVGTLPAQAIDSATCTKSEQDAASRYNILPRKRTLSDLLDSLPSLKAMQSNEGSYKRRKLVESAGTHLSKSPMLISSDISGKTEEYSYGSLIAEANKGNAPSSIYVSALLHVVRHCSLCIKHARLTSQMEELDIPYVEEVGLRSASSNLWFRVPFARDDGWQHICLRLGRPGSMYWDVKINDQHFQDLWELQKGSNSTPWGSGIRIANTSDADSHIRYDCEGVVLSYYSVNADSIKKLVADIQRLSNARTFAFGMRKLLGARADEKFEENNVNSESKASAAIKGSADATDRISEQMRKQFRIEAVGLMSLWFSFGSGVLARFVVEWESGKEGCTMHVSPDQLWPHTKFLEDFINGAEVASLLDCIRLTAGPLHALAAATRPARAAPVSGVPGVTAPISSAAKQASYVPSLPSNVNSSINQPASGPGVNPVSATVGTLGTHSHPSAAMLAAAAAAAGRGGPGIVPSSLLPIDVSVVLRGPYWIRIIYRKKFAVDMRCFAGDQVWLQPATPPKGGPEVGGSLPCPQFRPFIMEHVAQELNGIDNFTGSQQAVGLTNSNSINAGSQLPAANTNRNNLSNSTGLARPANAVNGFSRTANGLPAASNLAGVNAGMPLRRQPGTGVPAHVRGELNTAIIGLGDDGGYGGGWVPLVALKKVLRGILKYLGVLWLFAQLPDLLKEILGSILKDNEGALLNLDQEQPALRFFVGGYVFAVSVHRVQLLLQVISVKRFHQSQQQQQQNPGSAQEELTQSEIGEICDYFSRRVASEPYDASRVASFITLLTLPISVLREFLKLIAWKKGLSQVQGGDMVPTQKSRIELCLENHAGYSNDGSSENTSASKSNIHYDRAHNCVDFALTVVLDHAHIPHINAAGGAAWLPYCVSVRLRYAFGENPNVLFLGMEGSHGGRACWLRVDDWDRCKQRVARTVEVNGNSAGDANQGRLRVVADSVQRTLHAYLPGLRDGGGIAAGIGS
Length1778
PositionTail
OrganismCapsicum baccatum (Peruvian pepper)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> eudicotyledons> Gunneridae> Pentapetalae> asterids> lamiids> Solanales> Solanaceae> Solanoideae> Capsiceae> Capsicum.
Aromaticity0.07
Grand average of hydropathy-0.165
Instability index43.93
Isoelectric point8.03
Molecular weight192654.82
Publications
PubMed=29089032

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP15795
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      98.40|      30|      66|    1176|    1206|       1
---------------------------------------------------------------------------
 1176- 1206 (50.04/33.95)	TAGPL....HALAAATRPARAAPVSGVPGVtAPIS
 1241- 1274 (48.36/28.12)	TVGTLgthsHPSAAMLAAAAAAAGRGGPGI.VPSS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     160.60|      53|     354|    1295|    1418|       2
---------------------------------------------------------------------------
  729-  783 (80.54/18.01)	GSAGSLAAT.PGRIQTGKKLPASKSEQ....DLTSLRSPHSAgVGSYtSLDEDQLTVSSN
 1353- 1410 (80.06/94.22)	GSQQAVGLTnSNSINAGSQLPAANTNRnnlsNSTGLARPANA.VNGF.SRTANGLPAASN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     148.52|      36|     353|    1295|    1330|       3
---------------------------------------------------------------------------
  948-  968 (23.33/ 9.20)	........VGLRS...A.SSNL.......WFRVPFARD..DG.........
 1105- 1143 (23.77/ 9.53)	RKQFrieAVGLMSlwFSfGSGVlarfvveW.......E..SGKE.GCTM..
 1145- 1172 (32.54/16.09)	...............VS.PDQL.......WPHTKFLEDfiNGAEVASLLDC
 1295- 1330 (68.89/43.24)	RKKF...AVDMRC..FA.GDQV.......WLQPATPPK..GGPEVGGSLPC
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     121.99|      39|     404|      99|     156|       4
---------------------------------------------------------------------------
   99-  142 (58.00/49.09)	FFMHEGLQQARAPIyDVPSAV....EVLLTGsygrLPKCIGDLGLQSS
  517-  559 (63.99/36.47)	FLGLEVFEHGSASV.KVPKSIscgtNFLLMG....FPECGSSYFLLME
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     199.98|      64|     404|     391|     495|       5
---------------------------------------------------------------------------
  209-  275 (103.05/53.87)	HM.ELLVGERSGPMKLDDfrRHALGDDLeRRMAAADNPFMTL.......YSILHELCMALVMDTVIRQVQTLRQG
  420-  491 (96.93/ 7.29)	HVeEVLADSRKKDNKFDS..REYQGQEV.LRVRAFGSSFFTLainirngHFILHSSKNVISSSVVVECEEALNQG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      85.90|      19|     190|     704|     722|       6
---------------------------------------------------------------------------
  668-  683 (26.52/12.98)	GS.SVPSF...SGQLPPSTF
  684-  703 (25.91/12.49)	GApPASHFGSGVANYQNLKV
  704-  722 (33.48/18.51)	GT.LSPKWDRGAGNYSSSIY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      62.83|      19|     404|     624|     646|       7
---------------------------------------------------------------------------
  597-  615 (33.78/15.87)	DVGRMQICEDKL..NLSLLNS
  625-  645 (29.05/20.84)	DGGSHQSSENSLlaDFSLEGS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     166.63|      36|     259|    1412|    1453|      11
---------------------------------------------------------------------------
 1412- 1451 (61.53/44.19)	AG.VNAGMPLRRqpgtGVPAHVR...GELNTAIIGLGDDGGYGG
 1677- 1712 (54.28/28.39)	AG.GAAWLPY......CVSVRLRyafGE.NPNVLFLGMEGSHGG
 1740- 1774 (50.82/24.61)	AGdANQGR.LRV.....VADSVQ...RTLHAYLPGLRDGGGIAA
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP15795 with Med14 domain of Kingdom Viridiplantae
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