<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP15762

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMDFINGCTTNVHLLDGFSTTAFTQYTHIAPHSNVYQKIKDAQSKVVELRWSKALCTLVDQDIWVFGDGEHDLGSSYTIAKTGTVEGRKDVTCLLLHAIESALAFTLAQKGHLTHVAPWTWLYCSRSLEDEPDILMVTLRVKDTPNGALYLLSEVTPSTWMPSDQASDHVNEDVLVAPHGKIAVIAAEDATGVTADVQWKESVTDXLKLDGIALDEDAEWINVELSEDGTTSIFTWPSELCLLRQSLPLPAQLAWADRTEWQTWTDNGQGRLYRDPLAEAEDWFAGFAERISRAAEEADKEAAHMESNGPSSFAIANDISMTTSPPFMQRTVDHQVAMSGMYPTPPDGLAQQGQTQLGAQSAMSAATPSMVPVGDTAAAPEIINDAQDHGDDALGLGSYSMDEVEEDLFGDVGGEMFEENEVGDADFDYFDEPDDEPAAEASAGEVDTEMTDMPVVDNRSDLCIDDTADGTDAEPVDLHRKSGPVLQPVSSPPSAALSSRLATDPKVDEQASEIKRRPLSPFGIRERLLPPPVPASVAHGSDTSKQLRRSSSFAPIIFRDGVDLAAKYASVDVGPDFVGNVSASEPSIALPPFRTADQSDDDSDESESAASETDDGELPPRLPWEATKKRKRGGHVVDTGSADFGGTWREENTGVYEGNDDNEQQRSLRRALLDQVLCATLPRNEELFVKQASPAIKQSKEEDGELPSLEELYDLEKEDLIYIAQLVSEQSATCLATRPSPSSRHSRSAFTATLLIKALADLLSSPFEICDVSRLALTRDPAPQPRAIPRAPVPPRSGPDIPDIFSLPAPFVRIQRNNDKWEMLPPALSFWEPNGLAAASGPKHVRARAIFPSNSDLKDATRGFMEALGRAYEGCKLGTHSYATYDNGEFDGGALVEEEGEESSKSALLKGYAKACARVGRELAIWFSAFGWQSGWDGTFVVYMLDPFTGEGWAGGKKYMCACFWTLFQAYLDRLKPGNKSRGNSAVPDVVLQVIPIEHVASMDRLIIPDPLMLASLAREVYDRCPAPLSVEGEGDGEASPSILLAPPVPKRIAFQLLADVPAESLLQDGRVLHLAAVMSGDREWMNCVWSDGQGRNVLQESFCLRGLTVGTVVRQAWERTCELIGRMRVVWRVFVALEEGVWSGVGLERVWRDVVTSGRVGDMIVCVTLVKTFVKLGLEVAAELGCGDGVMGLATPASTPIAFPGGNGATTGTSSPNVSASDGFGAPLTPAPSESTISGAVAAMQVLENDPDAHLVEVEDESCGMLFKPQLSALTGMDGMANGAIIRRGRGDASMRALLGVSLYWTLQVKSQGGGAVEIGSLRQAEVTLREVLRMYRALGVLTRARGLYEGEGGVQPVHLAVACKGARGLEGMMS
Length1375
PositionKinase
OrganismRamularia collo-cygni
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Dothideomycetes> Dothideomycetidae> Mycosphaerellales> Mycosphaerellaceae> Ramularia.
Aromaticity0.07
Grand average of hydropathy-0.234
Instability index43.70
Isoelectric point4.58
Molecular weight148383.84
Publications









Function






Annotated function

Component of the SRB8-11 complex. The SRB8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The SRB8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.



ECO:0000256	RuleBase:RU364134

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP15762
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     110.48|      36|      86|      12|      49|       1
---------------------------------------------------------------------------
   12-   49 (58.78/60.22)	HLLDgfSTTAFT.....QYTHIAPHSNVY..QKIKDAQS.KVVELR
   96-  139 (51.70/43.32)	HAIE..SALAFTlaqkgHLTHVAPWTWLYcsRSLEDEPDiLMVTLR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      74.58|      20|      55|     873|     904|       2
---------------------------------------------------------------------------
  873-  892 (40.05/34.48)	GCKLGTHSYATYDNG..EFDGG
 1185- 1206 (34.53/10.51)	GCGDGVMGLATPASTpiAFPGG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     217.80|      51|     204|     909|     970|       3
---------------------------------------------------------------------------
  251-  285 (37.64/14.09)	.........QL...A.WADRTEW.QT..WtdNGQGRLYR.DPLAeAEDWFAG.........
  912-  964 (93.28/72.18)	AKACARVGREL...AIWFSAFGW.QSG.W..DGTFVVYMLDPFT.GEGWAGGKKYMCAcfW
 1069- 1117 (57.29/24.92)	.......GRVLhlaAVMSGDREWmNCV.W.sDGQGRNVLQESFC.LRGLTVGTVVRQA..W
 1118- 1146 (29.59/ 6.16)	ERTCELIGRMR...VVWRVFVAL.EEGvW..SGVG..........................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     285.63|     117|     215|     298|     448|       4
---------------------------------------------------------------------------
  298-  378 (84.46/57.22)	..........................................................................DKEAAHM.ESNGPssfaIANDISmttSPPfmQRTVDHQVAMSG......................MYPTP.PDGLAQQGQTQLGAQSAMSAAtPSMVPVG.DTAAA
  398-  566 (158.88/112.48)	YSMDEVEEDLFGDVGGemfEENEVGDADFDYFDEPDDE.PAAEASAGEVDtemtdmpvvdnrsdlciddtadgtDAEPVDLhRKSGP....VLQPVS...SPP..SAALSSRLATDPkvdeqaseikrrplspfgirerLLPPPvPASVAHGSDTSKQLRRSSSFA.PIIFRDGvDLAAK
  567-  613 (42.30/ 6.87)	YASVDVGPDFVGNVSA...SEPSIALPPFRTADQSDDDsDESESAASETD..................................................................................................................................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     124.81|      40|     207|     617|     656|       7
---------------------------------------------------------------------------
  617-  656 (76.16/42.37)	LPPRLP.WEATKKRKRGG..HV....VDTGSADFGGTWR..EENTG.VYE
  823-  872 (48.65/24.41)	LPPALSfWEPNGLAAASGpkHVraraIFPSNSDLKDATRgfMEALGrAYE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      82.44|      23|     499|     215|     237|       8
---------------------------------------------------------------------------
  215-  237 (42.89/26.82)	EDAEWINVELSEDGTTSIFTWPS
  717-  739 (39.55/24.16)	EDLIYIAQLVSEQSATCLATRPS
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP15762 with Med13 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) GNVSASEPSIALPPFRTADQSDDDSDESESAASETDDGELPPRLPWEATKKRKRGGHVVDTGSADF
2) NEVGDADFDYFDEPDDEPAAEASAGEVDTEMTDMPVVDNRSDLCIDDTADGTDAEPVDLHRKSGPVLQPVSSPPSAALSSRLATDPKVDEQASEIKRRPLSPFGIRERLLPPPVPASVAHGSDTSKQ
3) SPPFMQRTVDHQVAMSGMYPTPPDGLAQQGQTQLGAQSAMSAATPSMVPVGDTAAAPEIINDAQDHGDDALGLGSYSMDEVEEDLFGDVGGEMFE
578
419
323
643
545
417










Molecular Recognition Features






MoRF SequenceStartStop




1) IGYHYL
2) PAVFTEAKTTVKSEKKSGGKIKRRKSKAN
195
332
200
360