<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP15760

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMTKGLPTPPEIDQSWRQSDANKPMGVMMERLAQQCMADLNDTLTKMAEAPQAPAQANGIVPHATDTSEASLSRKRALIEFAHNQRDRFIKTLVLSDWARNADDMARLVDIKVWQEKQVAAQHAAMRFIGTMKTNMAGAKMPNPNIEGALELLATGKASHIPDLGYLPPKRLTAKQLLRTLQDMNVALATRLNLHEELPFHFNDFSIANGRATFQVPQEFEVDLSVADEDTSTPFYFIDIRFLFNPAPTLSDEGLRGVLENHANIALAKDGTKGCYDLIHNFVLTHKINVLRDQTFNLLREKWFDCLVVELKKRVLIIQYWSIMPGPKSWLEIGVSTGRRQAKRAQAATPQLAVRWFRNGKEATLEEDAIHVDWQDISAEAVLAVTTAKHVSWMLGTIKDRLRKLSSATNKLTINLTTSASNPEACSLALSLPGLRIPLTVKLSGVTGRWSISPATSSTARVEHAINADHTSDIATSLVQLLAQLVQERVGKAAELAGWKSIPRQALVPLTSASVVALFGTGVIARSIYRCSVGWGDSWALVVTFGLAGEKWWASRLEQSTSDSKLRVIAEARRISANLFTDCSVSRAQLLRVEKSAAAEISMAVLTQELREQSIRFKVETTTPLDARSADAGPERPSTSSTAVVFDAAPLVKSGPDATPRTLKTDVIRLIHTGVSVIESADGEQSGMRHSIRLTVKPGSLGHLQTYLATKNRDSDIAMNKSGALALQLMTPFGQRYTQRIRARLEACGRFNEYLTILNMYKHRVLKLNLRRFEFVYSEEPRLTATLNFDGNDGGLPVSLKLGPANTNPHHRGRVQMELALNSLSKKAPPAAFHTMLRILTSTIPAFQTFDKIEISRPVGSVAIHIHSPLAFVVEYKAPLPACKIILHLRSRAKGFHWKVGTPLGENDGRGLPDPVRFAFLKLCQDRGEGWFGDGKAACVVEMPGIVEVLMRVDGIMREFGGAEADKGNALDASENGGQDATTFKSAGKKDPRQEIIELD
Length999
PositionTail
OrganismRamularia collo-cygni
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Dothideomycetes> Dothideomycetidae> Mycosphaerellales> Mycosphaerellaceae> Ramularia.
Aromaticity0.06
Grand average of hydropathy-0.196
Instability index40.52
Isoelectric point9.16
Molecular weight109998.98
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP15760
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     218.46|      77|     126|     320|     405|       1
---------------------------------------------------------------------------
  320-  405 (123.02/106.56)	WSI............MPGPKSWLEIGVS..TGRRQAKRAQAATP...................QLAV..rwfRNGKEATLeedaihVDWQDISAEAVLAVTTAKHVS.WMLGTIKDRLRKLS
  416-  531 (95.44/63.12)	TTSasnpeacslalsLPGLRIPLTVKLSgvTGRWSISPATSSTArvehainadhtsdiatslvQLLAqlvqeRVGKAAEL......AGWKSIPRQALVPLTSASVVAlFGTGVIARSIYRCS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     124.80|      38|     555|      20|     126|       2
---------------------------------------------------------------------------
   24-   61 (65.42/112.94)	MGVMMERLAQQCM..ADLNDTLTKMAEAPQAPAQANGIVP
  128-  167 (59.38/ 7.89)	IGTMKTNMAGAKMpnPNIEGALELLATGKASHIPDLGYLP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     204.79|      65|     555|     223|     296|       3
---------------------------------------------------------------------------
  223-  296 (91.50/95.46)	LSVADEDTSTPfyfidIRFLFNPAPTLSDEGLRGVLENHANiALAKDGTKGCYDLIHNfVLTHKINVLrdQTFN
  786-  850 (113.30/82.17)	LNFDGNDGGLP.....VSLKLGPANTNPHHRGRVQMELALN.SLSKKAPPAAFHTMLR.ILTSTIPAF..QTFD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     134.24|      41|     278|     592|     634|       4
---------------------------------------------------------------------------
  592-  634 (60.34/41.66)	VEKSAAAEISMAVLtqELREQSIRFKVETTTPLDARSADAGPE
  873-  913 (73.90/45.37)	VEYKAPLPACKIIL..HLRSRAKGFHWKVGTPLGENDGRGLPD
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP15760 with Med14 domain of Kingdom Fungi
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