<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP15759

Description Mediator of RNA polymerase II transcription subunit 16
SequenceMDSNDIGEPAMVEAAMMDPTMEDLFGDAADGLNVGMPPAPLPASLILRIAEMQSRGCCAKLAWGNTGIIAHISADGSKVSFYTLVRDMKRKQWAISEPSKCPVEAPQGRTFVHVQFSGIGIDLAIVDSAGMVHMRSLAGALGRMVPAERDPTREIQPKNELDAVVGMHWLCLWPAEFTGPYIHPANKINDRWEAHLQQREQHSIKAHHPATXRHAMLHISRSTELTLQYQNEGQGWLSTSIFLETIRSSDESISHAALGEEGADLFAVTYDNSCRIRLYRVTIEWNATQHSRGPGQTYTLVTPTLEVHRLTASHNAMPQHADGARLTHLRLIPTAPEATQSPPTLPTVLAVFTQTSFLVDAAQSQGSFSVIAQWRVESSMPSLHTSFKKLTGMDSKAVQNPITVLKRSPDIMTNKVILSVRSQMFDTIIAFGASDGTVEMRERVTMDVIGPFGDTSTASNLPSSGFDHLAGPHNNHVAMSADSSGVXVVNADGKLAARTMAFTHGWQVMEDDIGDNRPFIEAAAVCVARQYAFLCYNSISNDESLALLPIEASPELRSTVVKTTFKMVNKSPDISMHENGRQQMTVVKEPVVPRVLSVQLALGTDHTTGVRSLAGQYAFAVLNLRHISTAIVHTVSVKDVSRVSTEAVHSLRTLVRWSIDLIIYIVDTLHEVKRTLQKDPSKTAKQAFEDLMAKSASPAIHLLLCSFSRALLRLQVSWIGKYIQVSHQVAPRAHSVAARMDLTAMFEQMAKLPVKLHQVEIMLGEFDTAIRNAYNPATLHADRRSEIEIAMIVDGAIPVELEPALNSLMDTMLPKLSETTDISELFFWNTNHLQLDRSKPRAVGETRYDVIRKVVLKQGMKLRICRRCGAEMEDLPHDKTREMPVWLLHAQKHCICMNYWVLA
Length903
PositionTail
OrganismRamularia collo-cygni
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Dothideomycetes> Dothideomycetidae> Mycosphaerellales> Mycosphaerellaceae> Ramularia.
Aromaticity0.06
Grand average of hydropathy-0.124
Instability index46.94
Isoelectric point6.55
Molecular weight99696.34
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP15759
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      92.52|      26|      27|     279|     304|       1
---------------------------------------------------------------------------
  279-  304 (49.48/35.96)	YRVTIEWNA.TQHSRGPGQTYTLVTPT
  308-  334 (43.04/30.23)	HRLTASHNAmPQHADGARLTHLRLIPT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      64.29|      21|      25|     753|     777|       2
---------------------------------------------------------------------------
  756-  777 (33.61/30.87)	LH.....QVEIMLgEFDTAIRNAYNPA
  779-  804 (30.69/14.03)	LHadrrsEIEIAM.IVDGAIPVELEPA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     332.00|     115|     486|      90|     228|       3
---------------------------------------------------------------------------
   90-  228 (163.92/156.70)	RKQWAIsepSKCPVeAPQgrtFVHVQFSgIGIDlaivDSAGmvhMRSLAG..............ALGRMVPAeRDPTReiqpkNELDAVVGMHWLCLWPAE...FTGPYIHPANKI..NDRWEAHLQQREQHSIKAHHPATxrHAML.HISRSTeLTLQ
  581-  715 (168.08/102.27)	RQQMTV...VKEPV.VPR...VLSVQLA.LGTD....HTTG...VRSLAGqyafavlnlrhistAIVHTVSV.KDVSR.....VSTEAVHSLRTLVRWSIDliiYIVDTLHEVKRTlqKDPSKTAKQAFEDLMAKSASPAI..HLLLcSFSRAL.LRLQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      52.36|      15|      18|     450|     465|       4
---------------------------------------------------------------------------
  450-  465 (23.45/21.80)	GPFgDTSTASNLPSSG
  471-  485 (28.91/20.64)	GPH.NNHVAMSADSSG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      86.60|      25|      29|     497|     522|       5
---------------------------------------------------------------------------
  497-  522 (42.85/37.17)	ARTMAFTHGWQVMEDDIGDNRPfIEA
  528-  552 (43.74/31.84)	ARQYAFLCYNSISNDESLALLP.IEA
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP15759 with Med16 domain of Kingdom Fungi
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