<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP15756

Description Uncharacterized protein
SequenceMDYRPPPDSQRPLPPQRAVSGSYALQQGPRRAPLPSRLQNVRSVSQPGLQVDNTRDGATVGVRNTAAFLSNHGIVSSPGGGQDSDGEMSRPAKRAKIETEASRGADNETLATRNDIAHLVIPGSPLPAIPKPTRVAHKPSTNTNQRRAKIDRTARQANGIEPPSIATRLPAPKYAADFGPWKGTHPEDVLSEYAVKSGYFDKAPGPNSTESNSAKPTIWPNLSQKNNMGLQTLSYLFTQVMEKRQMMGRCTAPSTFKPPPRVTVTDTKREAWLRDLSNPEVPLRKQSRTIPHGIRGKLLMEQCLGKDIPLPRAVWLAKCVGANELRAFRRKGVSGAIAASGESKWVREWTIHVEQFLEGAITSCGQPEWQAKMNYAVKLATSFYTERLLERDHYLDWIVSSFAGAGPETLPVWIIVVQLYWHDIIAFVRRGRKLAQAMLGILHRSACGSISIGDMLEARLKKLIVVMAVASRGCLIIPKTWEKYSYLLVPHTFGLDYSRFLAHAQNLKRRNSRLTLPLRKTSESTRSASLNLYSILDAATLNVDFEALTARCLASVSDVTKLVPALLSWSASVYRAGTARIYLATGVLSQLNSLGYYTDEIVMDFVKTGSTSPIIAGNVYRVIAELIRANSFSAGRYLQWLMTSGSLTQANRSLFSNGLLSALPLDALQPHLLNSRNMLQRRLGNVEDESALVEAVLARVESAADEGPELEVDMNIVSDTAKLAVARQVSMRAAMRAKAGTTTLRYFCRVRVVLEACGDLRALADVLQSTSLTEDPALLATMADTVNIHSVSFGALGCFQALLWQLLERYNVLRSQQPLDRRFIIALKSLAKRFPENGHLFGHLEQDLVLCEQQNSANVCSPASDSIVSMQASNLASDSDIDAVFASGNNMDEQLMQRIFSRVVQRARKTTLPDIQFPSKICGWLEQLRAVAVDPCSFDQMAINHIQACLKDPAQVVSPCNVITALVASGCTSFAAMVNEAKSPVAASVMVRLLTSKAVAYEGLHAAETYHFRVQQQRYCFDHADAVIRLFVTALDHPDLLLEDPGLVDLILNYPITHLKEVTEALAGRSWSQASLANCSRLAATLMGLGRDFGTLDTQSIVANADALSIAYCAGALKLHAKLTPETSDEVQQAVLNAIADGSEVWPQLLSSVDESIVQEIYRWARDQVMEKAFDSERLNPFELSKILRSLEILDVTVHAAKQDDRGTVVPMIVEQLKALDTRLTTLGIVDLEEEHSQPTVRSLRILLHLSILYSGTSSTRNELSEQSHCQLLGSLCNLLVHSHLQGQQELLEYIYDIASAMVDNLSEANLSMLARSFAGRDNRLSSLLGTYPSPDAWLAIASHPQPQGTQQQRTLMKQSGSQQXVPGRQPPQQSPVQQHGFQRPPVRADGRPVIDVKMVPFPLRRWEIISDATPMIGDNDTSLSLGLFGARKV
Length1434
PositionKinase
OrganismRamularia collo-cygni
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Dothideomycetes> Dothideomycetidae> Mycosphaerellales> Mycosphaerellaceae> Ramularia.
Aromaticity0.06
Grand average of hydropathy-0.161
Instability index45.01
Isoelectric point8.64
Molecular weight157631.53
Publications









Function






Annotated function

Component of the SRB8-11 complex. The SRB8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The SRB8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.


Component of the srb8-11 complex. The srb8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The srb8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.



GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP15756
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     698.55|     232|     251|     830|    1076|       1
---------------------------------------------------------------------------
  830- 1076 (357.40/304.67)	LAKRFPENGHLFGHLE.QDLVLCEQQNSANVCSPA..SDSIVSMQASNLASDSDIDAVfASGNNMDEQLMQRIFSRVVQ...RARKTTLPDIQFPSKICGWLEQLRAVAvdpcSFDQMAINhIQACLKDPAQVVSPCNV..ITALVASGCT.SFAAMVNEAKSPVAASvmVRLLTSKAVAYEGLHAAETyhfRVQQQRYCfDHADAVIRLFV.TALDHPDLLLE...D..PGLVDlilNYPITHLKEVTEALAGRSWSQASL
 1082- 1328 (341.15/243.46)	LAATLMGLGRDFGTLDtQSIVANADALSIAYCAGAlkLHAKLTPETSDEVQQAVLNAI.ADGSEVWPQLLSSVDESIVQeiyRWARDQVMEKAFDSERLNPFELSKILR....SLEILDVT.VHAAKQDDRGTVVPMIVeqLKALDTRLTTlGIVDLEEEHSQPTVRS..LRILLHLSILYSGTSSTRN...ELSEQSHC.QLLGSLCNLLVhSHLQGQQELLEyiyDiaSAMVD...NLSEANLSMLARSFAGRDNRLSSL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     138.09|      42|     252|       3|     105|       2
---------------------------------------------------------------------------
    7-   52 (66.36/29.78)	PDSQrplPPQRAVSGSYALQQGPRRA...........PLPSRLQNVRSVSQPGLQvD
 1367- 1419 (71.73/33.08)	PGRQ...PPQQSPVQQHGFQRPPVRAdgrpvidvkmvPFPLRRWEIISDATPMIG.D
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     315.79|     116|     252|     234|     363|       3
---------------------------------------------------------------------------
  234-  294 (39.37/48.24)	................................................................................SYL.........FTQVMEKRQMMGRCTAPSTFkpPPRVTvTDTKREAWLRDLSNPEvplrkqSRTIphGI
  295-  363 (82.97/55.83)	RGKLLMEQCLG..KDIP..LPRAV.WLAKCVGANELRA.FRRKGVSGAIAASG....ESKWVREWtihVEQFLEGAITS.......................................................................
  430-  543 (133.20/87.26)	RGRKLAQAMLG.....I..LHRSA.CGSISIG.DMLEArLKKLIVVMAVASRGcliiPKTWEK................ySYLlvphtfgldYSRFLAHAQNLKRRNSRLTL..PLRKT.SESTRSASLNLYSILD......AATL..NV
  544-  612 (60.25/31.53)	DFEALTARCLAsvSDVTklVPALLsWSASVYRAGTARI.YLATGVLSQLNSLG......YYTDEI...VMDFVKTGSTS.......................................................................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      85.27|      29|     138|     617|     683|       4
---------------------------------------------------------------------------
  627-  666 (42.28/83.52)	IRANSFSA.GRY..LQW.LMTsgsltqanRslfSNGLLSALPLD
  788-  820 (42.99/ 9.77)	IHSVSFGAlGCFqaLLWqLLE........R...YNVLRSQQPLD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      99.97|      34|     532|     140|     180|       5
---------------------------------------------------------------------------
  140-  180 (43.91/48.11)	STNTNQRRakIDRTARQANGIEppSIATRLPApkyAADFGP
  675-  708 (56.07/34.65)	SRNMLQRR..LGNVEDESALVE..AVLARVES...AADEGP
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP15756 with Med12 domain of Kingdom Fungi
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