<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP15747

Description Mediator of RNA polymerase II transcription subunit 17
SequenceMTSSLAFRPWDVAASTDPPPLKDTLARVAAERGHFRDITEAALLAEIEANSSSSEKDDDEDDNDDTSDTSADNEAGGQAKTVGELYTSRNEMLTYINAAQQEIAMALDFVSLLSTVQFPAAATTISPMLKNQGIPMASLGMDFWHKMPADPVREEEEAKLARAVRFSQLRESADDLLAAAERLEGNVRRERVFWEQILGVEERGWRVSRIPRAHGLLGVHFGFNGAAREFAERDLAALVAGEEDGGIVLERGVGTKPKAMRVLIKKDGRVVGSSNLPNEKFDGEEAGLEARIRAARDSLFDEELQHEMVREARGLLSLGVNMQGNTLSFPADDNHTKTIDLQLISLDEDNSLPPDSLHGSDDMAQALLLSARLLLSHSHRETLARRSQPPPPMSEKKDTETPVLALLRPLLRILKHVNDIFVLNTYLTNLQTVLGHADIDIRSTPAKFTLPLPSTPDSATLITTLLQPLRTTANLTLPGIETSPMTLDFRIETSPTTHSYTLILSTENQTYNLLTLEDLFEAADDFLAAELIARLHSASPIQGAVWELDKREGIMMRLGPNGEDDREIFSCRIWGQQGKMELHREGADGMHVVWGGEREELMSLWQAWREVVPAVDLDSHAAEEER
Length626
PositionHead
OrganismRamularia collo-cygni
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Dothideomycetes> Dothideomycetidae> Mycosphaerellales> Mycosphaerellaceae> Ramularia.
Aromaticity0.05
Grand average of hydropathy-0.362
Instability index42.10
Isoelectric point4.77
Molecular weight69255.07
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP15747
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     151.95|      38|      39|     167|     204|       1
---------------------------------------------------------------------------
  167-  204 (62.11/35.51)	SQL.RESADDLLAAAERLEGNVR..R..ERVFWEQI...LGVEERG
  208-  246 (50.84/27.81)	SRI..PRAHGLLGVHFGFNGAAR..EfaERDLAALV...AGEEDGG
  274-  314 (38.99/19.71)	SNLpNEKFDGEEAG...LEARIRaaR..DSLFDEELqheMVREARG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      76.76|      25|      28|     328|     352|       3
---------------------------------------------------------------------------
  328-  352 (41.32/27.82)	SFPADDNHTKTIDLQ...LISLDEDNSL
  356-  383 (35.44/22.81)	SLHGSDDMAQALLLSarlLLSHSHRETL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     147.48|      36|      36|     441|     476|       4
---------------------------------------------------------------------------
  386-  422 (41.61/21.87)	.RSQPPP...PMSEKKDTETPVLALLRPLlrilkHVNDIFV
  441-  476 (57.96/33.09)	IRSTPAKFTLPLPSTPDSATLITTLLQPL.....RTTANLT
  480-  513 (47.92/26.20)	IETSPMTLDFRIETSPTTHSY.TLILSTE.....NQTYNL.
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP15747 with Med17 domain of Kingdom Fungi
Unable to open file!