<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP15745

Description mediator of RNA polymerase II transcription subunit 25 isoform X4
SequenceMVTLMDSAPKPGASQVSDVVFVIEGTANLGPYFESLRKNYILPAIEYFNGGPPAETDFGGDYGGTQYGLVVFNTVDCAPESYVQCHAPTSSAFEFVSWIDSIQFMGGGAESCSLIAEGLSVALQLFDDFKKMREQIGQTHKVCVLLCNSPPYLLPAVESVSYTGCTTDSLVQIIRDRGIHFSVVAPRKLPALRALYDRASPIGAPEPSHPDYSQDPFHMVLIRGIALPGTASVPFAPGGGSGSVALKPVLPQQPLPVIPICSASQPPPPISTTHAYPVTPSQSLNAAAAAAAMALEAATSQKTRFPGIMSSGPPFNTQPTLPTVGGVKLPPANQPSLSTVTTVSTPMLSQQPAPPQVPQQPQPQVLPPGQPTPNQQPPQALQQPPTANPQVPPSSQPVLPGVSAPQPGVNPIAAQQGVPNKVVAWSGVLEWQEKPKASIDSNTKLTRSLPCQVQVNQGENLNTEHWPQKLIMQLIPQQLLTTLGPLFRNSRMVQFLFTNKDVESLKGLYRIMGTGFAGCVHFPHSAPCEVRVLMLLYSSKKRIFMGLIPNDQSGFVNGIRQVITNHKQVQQHRTMGNAGQMQSTQVPTNQNFLNRPPGQIPVTHGNVQPQLTMRGAVTANQQPPVTGAPPNQVAQGQAQPPGAMLRLPNPGANPQLRSLLLSQQQPQSGVSHMQGMLPLQGLSQSMVHPTGAGAQIQPQWRQSIPGQMMMGAGPRGSVAQNPGMPQVSSVMEDEILMDLI
Length740
PositionUnknown
OrganismIctalurus punctatus (Channel catfish) (Silurus punctatus)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Actinopterygii> Neopterygii> Teleostei> Ostariophysi> Siluriformes> Ictaluridae> Ictalurus.
Aromaticity0.06
Grand average of hydropathy-0.194
Instability index51.16
Isoelectric point8.45
Molecular weight78905.56
Publications









Function






Annotated function


GO - Cellular Component
nucleus	GO:0005634	IEA:UniProtKB-SubCell

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP15745
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      65.20|      21|      24|     362|     384|       3
---------------------------------------------------------------------------
  363-  388 (35.69/14.53)	PQVLPPGQPTPNQQPPqaLQQPptaN
  609-  629 (29.51/ 7.15)	PQLTMRGAVTANQQPP..VTGA...P
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      46.81|      15|      15|     672|     686|       4
---------------------------------------------------------------------------
  655-  669 (20.03/ 6.88)	QLRSLLLSQQQPQSG
  672-  686 (26.79/12.09)	HMQGMLPLQGLSQSM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     163.96|      48|      48|     205|     252|       5
---------------------------------------------------------------------------
  159-  231 (57.63/21.00)	SVSYT.GCTTDSlvqiirdrgIHFSVVAPRklpalralydraspigaPEPSH............................P..DYSQDPFHMVLIRGIALPGTA
  232-  280 (72.84/28.59)	SVPFAPGGGSGS.........VALKPVLPQ................qPLPVI............................PicSASQPPPPISTTH..AYPVTP
  281-  346 (33.50/ 8.96)	SQSLNAAAAAAA.........MALEAATSQ......................ktrfpgimssgppfntqptlptvggvklP..PANQ.P.SLSTVTTVSTP...
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      47.16|      13|      15|     693|     706|       6
---------------------------------------------------------------------------
  693-  706 (22.39/14.26)	GAQIQPQWRQSiPG
  711-  723 (24.78/11.45)	GAGPRGSVAQN.PG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      69.98|      22|      25|     486|     509|       7
---------------------------------------------------------------------------
  486-  509 (33.09/27.73)	LFrnSRMVQFLFTNK.DVESLKGLY
  515-  537 (36.89/23.71)	GF..AGCVHFPHSAPcEVRVLMLLY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      67.81|      21|     240|     390|     411|       8
---------------------------------------------------------------------------
  390-  410 (38.61/19.45)	Q.VPP...SSQPVLPGVSAPQPGVN
  416-  440 (29.20/ 8.57)	QgVPNkvvAWSGVLEWQEKPKASID
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      70.09|      24|      28|     550|     577|       9
---------------------------------------------------------------------------
  545-  570 (39.17/30.13)	MGLipNDQSG.......FVN.GIRQVITNHKQVQ
  575-  608 (30.92/12.24)	MGNagQMQSTqvptnqnFLNrPPGQIPVTHGNVQ
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP15745 with Med25 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) AAAAAAAMALEAATSQKTRFPGIMSSGPPFNTQPTLPTVGGVKLPPANQPSLSTVTTVSTPMLSQQPAPPQVPQQPQPQVLPPGQPTPNQQPPQALQQPPTANPQVPPSSQPVLPGVSAPQPGVNPIAAQQ
2) HKQVQQHRTMGNAGQMQSTQVPTNQNFLNRPPGQIPVTHGNVQPQLTMRGAVTANQQPPVTGAPPNQVAQGQAQPPGAMLRLPNPGANPQLRSLLLSQQQPQSGVSHMQGMLPLQGLSQSMVHPTGAGAQIQPQWRQSIPGQMMMGAGPRGSVAQNPGMPQVSSVM
286
566
416
731










Molecular Recognition Features






MoRF SequenceStartStop




NANANA