<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP15744

Description mediator of RNA polymerase II transcription subunit 25 isoform X3
SequenceMVTLMDSAPKPGASQVSDVVFVIEGTANLGPYFESLRKNYILPAIEYFNGGPPAETDFGGDYGGTQYGLVVFNTVDCAPESYVQCHAPTSSAFEFVSWIDSIQFMGGGAESCSLIAEGLSVALQLFDDFKKMREQIGQTHKVCVLLCNSPPYLLPAVESVSYTGCTTDSLVQIIRDRGIHFSVVAPRKLPALRALYDRASPIGAPEPSHPDYSQDPFHMVLIRGIALPVAPGGGSGSVALKPVLPQQPLPVIPICSASQPPPPISTTHAYPVTPSQSLNAAAAAAAMALEAATSQKTRFPGIMSSGPPFNTQPTLPTVGGVKLPPANQPSLSTVTTVSTPMLSQQPAPPQVPQQPQPQVLPPGQPTPNQQPPQALQQPPTANPQVPPSSQPVLPGVSAPQPGVNPIAAQQGVPNKVVAWSGVLEWQEKPKASIDSNTKLTRSLPCQVQVNQGENLNTEHWPQKLIMQLIPQQLLTTLGPLFRNSRMVQFLFTNKDVESLKGLYRIMGTGFAGCVHFPHSAPCEVRVLMLLYSSKKRIFMGLIPNDQSGFVNGIRQVITNHKQVQQHRTMGNAGQMQSTQVPTNQNFLNRPPGQIPVTHGNVQPQPVVVGMAPVSQVTMMDEQQRQNNMLTMRGAVTANQQPPVTGAPPNQVAQGQAQPPGAMLRLPNPGANPQLRSLLLSQQQPQSGVSHMQGMLPLQGLSQSMVHPTGAGAQIQPQWRQSIPGQMMMGAGPRGSVAQNPGMPQVSSVMEDEILMDLI
Length758
PositionUnknown
OrganismIctalurus punctatus (Channel catfish) (Silurus punctatus)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Actinopterygii> Neopterygii> Teleostei> Ostariophysi> Siluriformes> Ictaluridae> Ictalurus.
Aromaticity0.05
Grand average of hydropathy-0.200
Instability index51.88
Isoelectric point8.26
Molecular weight81017.05
Publications









Function






Annotated function


GO - Cellular Component
nucleus	GO:0005634	IEA:UniProtKB-SubCell

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP15744
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     191.76|      46|      46|     639|     684|       3
---------------------------------------------------------------------------
  369-  395 (34.46/ 7.32)	.......................QQPP.......................QALQQPPTANPQVP.PSSQPVLPG.
  443-  489 (46.44/12.48)	LPCQVQV...............nQGENL.nTEHW...........PQKLIM.QLIPQQLLTTLGPLFRNSRMVQF
  639-  677 (66.33/21.05)	.......................QQPPV..TGAP...........PNQVAQGQAQPPGAMLRLPNPGANPQLRSL
  678-  748 (44.53/11.66)	LLSQQQPqsgvshmqgmlplqglSQSMVhpTGAGaqiqpqwrqsiPGQMMMG.AGPRGSVAQ..NPGM.PQVSSV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     204.72|      54|      57|      50|     106|       4
---------------------------------------------------------------------------
   12-   56 (49.40/28.45)	......GASQVSDVVFvieGTANLGP..YFE.........SLRKNYI..LPAIEYFNGGppAET
   57-  111 (92.53/52.51)	DFGGDyGGTQYGLVVF...NTVDCAPESYVQCHAP....TSSAFEFVSWIDSIQFMGGG..AES
  113-  164 (62.79/30.20)	SLIAE..GLSVALQLF...DDFKKMREQIGQTHKVcvllCNSPPYLLPAVESVSYTG.......
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      66.66|      23|      34|     200|     231|       5
---------------------------------------------------------------------------
  177-  216 (27.70/22.71)	RGIHFSvVAPrklpalralydraSPIGAPEPSHPdysQDP
  223-  248 (38.97/12.82)	RGIALP.VAP..........gggSGSVALKPVLP...QQP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      47.28|      16|      38|     562|     584|      11
---------------------------------------------------------------------------
  562-  580 (18.94/11.48)	QVQQhrTMGNAgQMQSTQV
  593-  608 (28.33/11.81)	QIPV..THGNV.QPQPVVV
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP15744 with Med25 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) AAAAAAMALEAATSQKTRFPGIMSSGPPFNTQPTLPTVGGVKLPPANQPSLSTVTTVSTPMLSQQPAPPQVPQQPQPQVLPPGQPTPNQQPPQALQQPPTANPQVPPSSQPVLPGVSAPQPGVNPIAAQQ
2) HKQVQQHRTMGNAGQMQSTQVPTNQNFLNRPPGQIPVTHGNVQPQPVVVGMAPVSQVTMMDEQQRQNNMLTMRGAVTANQQPPVTGAPPNQVAQGQAQPPGAMLRLPNPGANPQLRSLLLSQQQPQSGVSHMQGMLPLQGLSQSMVHPTGAGAQIQPQWRQSIPGQMMMGAGPRGSVAQNPGMPQVSSVM
281
560
410
749










Molecular Recognition Features






MoRF SequenceStartStop




NANANA