<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP15743

Description mediator of RNA polymerase II transcription subunit 25 isoform X2
SequenceMVTLMDSAPKPGASQVSDVVFVIEGTANLGPYFESLRKNYILPAIEYFNGGPPAETDFGGDYGGTQYGLVVFNTVDCAPESYVQCHAPTSSAFEFVSWIDSIQFMGGGAESCSLIAEGLSVALQLFDDFKKMREQIGQTHKVCVLLCNSPPYLLPAVESVSYTGCTTDSLVQIIRDRGIHFSVVAPRKLPALRALYDRASPIGAPEPSHPDYSQDPFHMVLIRGIALPGTASVPFAPGGGSGSVALKPVLPQQPLPVIPICSASQPPPPISTTHAYPVTPSQSLNAAAAAAAMALEAATSQKTRFPGIMSSGPPFNTQPTLPTVGGVKLPPANQPSLSTVTTVSTPMLSQQPAPPQVPQQPQPQVLPPGQPTPNQQPPQALQQPPTANPQVPPSSQPVLPGVSAPQPGVNPIAAQQGVPNKVVAWSGVLEWQEKPKASIDSNTKLTRSLPCQVQVNQGENLNTEHWPQKLIMQLIPQQLLTTLGPLFRNSRMVQFLFTNKDVESLKGLYRIMGTGFAGCVHFPHSAPCEVRVLMLLYSSKKRIFMGLIPNDQSGFVNGIRQVITNHKQVQQHRTMGNAGQMQSTQVPTNQNFLNRPPGQIPVTHGNVQPQPVVVGMAPVSQVTMMDEQQRQNNMLTMRGAVTANQQPPVTGAPPNQVAQGQAQPPGAMLRLPNPGANPQLRSLLLSQQQPSGVSHMQGMLPLQGLSQSMVHPTGAGAQIQPQWRQSIPGQMMMGAGPRGSVAQNPGMPQVSSVMEDEILMDLI
Length763
PositionUnknown
OrganismIctalurus punctatus (Channel catfish) (Silurus punctatus)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Actinopterygii> Neopterygii> Teleostei> Ostariophysi> Siluriformes> Ictaluridae> Ictalurus.
Aromaticity0.05
Grand average of hydropathy-0.193
Instability index51.17
Isoelectric point8.26
Molecular weight81449.52
Publications









Function






Annotated function


GO - Cellular Component
nucleus	GO:0005634	IEA:UniProtKB-SubCell

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP15743
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      52.77|      15|      15|     313|     327|       1
---------------------------------------------------------------------------
  313-  327 (27.07/ 7.39)	PPFNTQPTLPTVGGV
  346-  360 (25.70/ 6.59)	PMLSQQPAPPQVPQQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      59.75|      21|      26|     361|     384|       2
---------------------------------------------------------------------------
  248-  268 (37.69/11.36)	P.VLPQ.QPLP.VIPICSASQP..PP
  363-  388 (22.07/12.71)	PqVLPPgQPTPnQQPPQALQQPptAN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     216.96|      35|      36|     606|     640|       3
---------------------------------------------------------------------------
  393-  437 (30.65/ 7.75)	.PS........SQPVLPGVsAPqpgVNPI.A..AQQGVPNKVVAW..SGvlewqekpkA
  580-  605 (34.36/ 9.55)	..Q........MQSTQV....P...TNQN.FL....NRPPGQIPV..TH.........G
  606-  640 (63.80/23.86)	NVQ........PQPVVVGM.AP...VSQV.TMMDEQQRQNNMLTM..RG.........A
  644-  676 (48.81/16.57)	NQQ........P.P.VTG..AP...PNQV.A.QGQAQPPGAMLRLpnPG.........A
  677-  715 (39.34/11.97)	NPQlrslllsqQQP..SG.......VSHMqGMLPLQGLSQSMVHP..TG.........A
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      37.86|      11|      71|     468|     478|       5
---------------------------------------------------------------------------
  468-  478 (18.25/10.40)	QKLIMQLIPQQ
  541-  551 (19.61/11.72)	KRIFMGLIPND
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     131.00|      41|      54|      42|      86|       7
---------------------------------------------------------------------------
   42-   86 (65.85/52.73)	LPAIEYFNGGppAET.DFGGDygGTQYGLVVFNTVDCAPESYVQCH
   99-  140 (65.16/38.41)	IDSIQFMGGG..AEScSLIAE..GLSVALQLFDDFKKMREQIGQTH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      46.45|      12|      26|     199|     210|      10
---------------------------------------------------------------------------
  199-  210 (24.06/10.30)	ASPIGAPEPSHP
  226-  237 (22.39/ 9.08)	ALPGTASVPFAP
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP15743 with Med25 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) AAAAAAAMALEAATSQKTRFPGIMSSGPPFNTQPTLPTVGGVKLPPANQPSLSTVTTVSTPMLSQQPAPPQVPQQPQPQVLPPGQPTPNQQPPQALQQPPTANPQVPPSSQPVLPGVSAPQPGVNPIAAQQ
2) HKQVQQHRTMGNAGQMQSTQVPTNQNFLNRPPGQIPVTHGNVQPQPVVVGMAPVSQVTMMDEQQRQNNMLTMRGAVTANQQPPVTGAPPNQVAQGQAQPPGAMLRLPNPGANPQLRSLLLSQQQPSGVSHMQGMLPLQGLSQSMVHPTGAGAQIQPQWRQSIPGQMMMGAGPRGSVAQNPGMPQVSSVM
286
566
416
754










Molecular Recognition Features






MoRF SequenceStartStop




NANANA