<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP15742

Description mediator of RNA polymerase II transcription subunit 25 isoform X1
SequenceMVTLMDSAPKPGASQVSDVVFVIEGTANLGPYFESLRKNYILPAIEYFNGGPPAETDFGGDYGGTQYGLVVFNTVDCAPESYVQCHAPTSSAFEFVSWIDSIQFMGGGAESCSLIAEGLSVALQLFDDFKKMREQIGQTHKVCVLLCNSPPYLLPAVESVSYTGCTTDSLVQIIRDRGIHFSVVAPRKLPALRALYDRASPIGAPEPSHPDYSQDPFHMVLIRGIALPGTASVPFAPGGGSGSVALKPVLPQQPLPVIPICSASQPPPPISTTHAYPVTPSQSLNAAAAAAAMALEAATSQKTRFPGIMSSGPPFNTQPTLPTVGGVKLPPANQPSLSTVTTVSTPMLSQQPAPPQVPQQPQPQVLPPGQPTPNQQPPQALQQPPTANPQVPPSSQPVLPGVSAPQPGVNPIAAQQGVPNKVVAWSGVLEWQEKPKASIDSNTKLTRSLPCQVQVNQGENLNTEHWPQKLIMQLIPQQLLTTLGPLFRNSRMVQFLFTNKDVESLKGLYRIMGTGFAGCVHFPHSAPCEVRVLMLLYSSKKRIFMGLIPNDQSGFVNGIRQVITNHKQVQQHRTMGNAGQMQSTQVPTNQNFLNRPPGQIPVTHGNVQPQPVVVGMAPVSQVTMMDEQQRQNNMLTMRGAVTANQQPPVTGAPPNQVAQGQAQPPGAMLRLPNPGANPQLRSLLLSQQQPQSGVSHMQGMLPLQGLSQSMVHPTGAGAQIQPQWRQSIPGQMMMGAGPRGSVAQNPGMPQVSSVMEDEILMDLI
Length764
PositionUnknown
OrganismIctalurus punctatus (Channel catfish) (Silurus punctatus)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Actinopterygii> Neopterygii> Teleostei> Ostariophysi> Siluriformes> Ictaluridae> Ictalurus.
Aromaticity0.05
Grand average of hydropathy-0.197
Instability index51.69
Isoelectric point8.26
Molecular weight81577.65
Publications









Function






Annotated function


GO - Cellular Component
nucleus	GO:0005634	IEA:UniProtKB-SubCell

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP15742
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             7|     405.13|      59|      59|     328|     386|       2
---------------------------------------------------------------------------
  186-  225 (56.26/12.85)	.......PRKLPALRALYDRASPIGAPEPSH..........PDYS........QD.PFHMVL...I...................RG....................................................I
  226-  270 (55.14/12.46)	A...LP...........GTASVP.F....APgggsgsvalkPVLP........QQ.PLP.VI...P...................IC..........SAS..................QPP................PPI
  275-  312 (38.69/ 6.81)	A...YP.VTPSQSLNAAAAAAAMAL..EAAT..........SQ..........KT.RFPGIM...S...................SG.....................................................
  328-  386 (116.03/33.38)	K...LP.PANQPSLSTVTTVSTPMLSQQPAP..........PQVP........QQ.PQPQVL...P...................PG..........QPTPN...........Q....QPP..........QALQ.QPPT
  390-  443 (54.03/12.08)	Q...VP.PSSQPVL...........................PGV.........SA.PQPGVN...P.................iaAQ..........QGVPNkvvawsgvlewQ....EKP..........KASI.DSNT
  587-  666 (42.56/ 8.14)	.......PTNQNFLN............RP.P..........GQIP...vthgnVQ.PQPVVVgmaPvsqvtmmdeqqrqnnmltmRG..........AVTAN...........Q....QPPvtgappnqvaQGQA.QPPG
  667-  746 (42.42/ 8.10)	AmlrLPnPGANPQLRS....LL..LSQQQPQ..........SGVShmqgmlplQGlSQSMVH...P...................TGagaqiqpqwrQSIPG...........QmmmgAGP..........RGSVaQNP.
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      87.19|      26|      26|     484|     509|       3
---------------------------------------------------------------------------
  484-  500 (23.93/10.30)	.................GPLFRNSRMVQFLFTNK
  501-  527 (38.29/20.68)	DVESLKGLY.....rimGTGF..AGCVHFPHSAP
  529-  557 (24.97/11.05)	EVRVLMLLYsskkrifmG.LIPND...QSGFVN.
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      58.79|      18|      48|      12|      32|       4
---------------------------------------------------------------------------
   12-   32 (27.99/30.21)	GASQVSDVVFvieGTANLGP..Y
   63-   82 (30.81/22.92)	GGTQYGLVVF...NTVDCAPesY
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP15742 with Med25 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) AAAAAAAMALEAATSQKTRFPGIMSSGPPFNTQPTLPTVGGVKLPPANQPSLSTVTTVSTPMLSQQPAPPQVPQQPQPQVLPPGQPTPNQQPPQALQQPPTANPQVPPSSQPVLPGVSAPQPGVNPIAAQQ
2) HKQVQQHRTMGNAGQMQSTQVPTNQNFLNRPPGQIPVTHGNVQPQPVVVGMAPVSQVTMMDEQQRQNNMLTMRGAVTANQQPPVTGAPPNQVAQGQAQPPGAMLRLPNPGANPQLRSLLLSQQQPQSGVSHMQGMLPLQGLSQSMVHPTGAGAQIQPQWRQSIPGQMMMGAGPRGSVAQNPGMPQVSSVM
286
566
416
755










Molecular Recognition Features






MoRF SequenceStartStop




NANANA