<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP15739

Description Mediator of RNA polymerase II transcription subunit 15
SequenceMSGMEVPGPDNDWRSQGFRQKVITQIEDAMRKAGTAHNKSSNDMENHVFNKAKTREEYLSMVARLIIHFRDIHKKAQGGADQMNPLQNLTVVGGAGGPGTIAMPPRAPGAPMGAMGSMNPMPIGQHAMQGVAGNQQGAGAAVQLQMAQQQQQSIQFQQFQPQQQTAMQQNAMQQQFQAQQQLKLQQQLQQQQQQQQQQQQQQQQQQQQHHQNQSMQHQNQQQQQAQAQQQQQQQNQLHQSRLQQQQMAQFQQLQQQQAHAQAQAQSIQHLQQQQQLQQAQAQPGQMPLHSQPPPQILVPQSLAGQMPSGQHQAIGTLSQQQQQQQLKLQAFQQARVLQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQVQQAHQAVAAQAQLVNVSGPMMPRAGIQMPPRLPRAIPNSAIPQNPAAMGGQQMPQGQQMSSPSPVQVQTPQPSMPPPPQPQPSPQPLSSQPNSVSSGPTPSPGGFQPSPSPQPSHSPATARTPQSYPLQVPSPGPLSTPGNPSSVMSPASASQSEDQLYMDKLKQLSKYIEPLRRMINKIDKNEERKKDLSKMKSLLNILTDPNTRCPLKTLQKCEIALEKLKNDMAVPTPPPPTVPSKKQYLCQPLLDAVLANIRSPVFNHSLYRTFAPAMTAIHGPPITGPIIPTRKRKYEEDDRQTIPNILQGEVARLDSKFLVNLDPSFCSNNGAVHLICKLDDKTLPSVPPLQLSIPSDYPEQSPQWDSDDQQYEANPFLQNVYRNMTSKLLQLPDKHSVTALLNTWAQSVRQACLSAA
Length800
PositionTail
OrganismIctalurus punctatus (Channel catfish) (Silurus punctatus)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Actinopterygii> Neopterygii> Teleostei> Ostariophysi> Siluriformes> Ictaluridae> Ictalurus.
Aromaticity0.03
Grand average of hydropathy-0.984
Instability index87.57
Isoelectric point9.53
Molecular weight89369.35
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU364148

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP15739
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      72.14|      15|      15|     338|     352|       1
---------------------------------------------------------------------------
  338-  352 (36.07/ 6.68)	QQQQQQQQQQQQQQQ
  366-  380 (36.07/ 6.68)	QQQQQQQQQQQQQQQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     142.75|      26|      26|     188|     213|       2
---------------------------------------------------------------------------
  188-  213 (56.77/12.66)	LQQQQQQQQQQQ.QQQQQQQQQHHQNQ
  215-  241 (45.10/ 7.82)	MQHQNQQQQQAQaQQQQQQQNQLHQSR
  270-  295 (40.88/ 6.07)	LQQQQQLQQAQA.QPGQMPLHSQPPPQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     138.62|      26|      26|     447|     472|       3
---------------------------------------------------------------------------
  431-  455 (43.32/11.54)	P.AAMGGQQMPQ.GQQM...SPSPVQVQT
  456-  483 (47.35/13.39)	PQPSMPPPPQPQPSPQPlssQPNSVS.SG
  484-  508 (47.95/13.67)	PTPS.PGGFQPSPSPQP...SHSPATART
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     178.00|      35|      37|     115|     149|       4
---------------------------------------------------------------------------
  115-  145 (48.97/10.70)	..........MGSMNPMPIGQHAMQGVAGNQQGAGAAVQLQ
  146-  183 (53.17/12.45)	MAQQqqqsiqFQQFQPQ..QQTAMQQNAMQQQFQAQQ.QLK
  242-  268 (38.11/ 6.16)	LQQQ.....qMAQFQQLQ..Q...QQ.A.HAQAQAQSIQ..
  304-  329 (37.76/ 6.01)	...........GQM...PSGQHQAIGTLSQQQ.QQQQLKLQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     225.40|      46|     112|     607|     652|       6
---------------------------------------------------------------------------
  514-  546 (37.05/15.55)	.....LQVPSPGP..LSTPG............NPS........SVM....SPAsasqS..E....DQLYM
  578-  605 (27.59/ 9.50)	KMKSLLNILTDPN..TRCPL............KTLQKCEIAL............................
  607-  652 (82.58/44.65)	KLKNDMAVPTPPP..PTVPS............KKQYLCQPLLDAVLANIRSPV....F..N....HSLYR
  677-  719 (39.01/16.80)	KYEED......DR..QTIPN............ILQGEVARLDSKFLVNL.DPS....FcsNngavHLI..
  721-  770 (39.16/16.90)	KL.DDKTLPSVPPlqLSIPSdypeqspqwdsdDQQYEANPFLQNVYRNMTS...................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     137.97|      41|     309|      70|     114|       7
---------------------------------------------------------------------------
   70-  114 (71.04/34.07)	RDIHKKAQGGADQmnplQNLTVVGGAGGP.GTIAMPPRAPGA.PMGA
  384-  426 (66.93/25.43)	QQVQQAHQAVAAQ....AQLVNVSGPMMPrAGIQMPPRLPRAiPNSA
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP15739 with Med15 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) HKKAQGGADQMNPLQNLTVVGGAGGPGTIAMPPRAPGAPMGAMGSMNPMPIGQHAMQGVAGNQQGAGAAVQL
2) MSGMEVPGPDNDWRSQGFRQKVITQIEDAMRKAGTAHNKSSNDMENHVFNKAK
3) QLQQAQAQPGQMPLHSQPPPQILVPQSLAGQMPSGQHQAIGTL
4) QQQQQQQQQQQQQQHHQNQSMQHQNQQQQQAQAQQQQQQQNQLH
5) QQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQVQQAHQAVAAQAQLVNVSGPMMPRAGIQMPPRLPRAIPNSAIPQNPAAMGGQQMPQGQQMSSPSPVQVQTPQPSMPPPPQPQPSPQPLSSQPNSVSSGPTPSPGGFQPSPSPQPSHSPATARTPQSYPLQVPSPGPLSTPGNPSSVMSPASASQSEDQLYMDKLKQ
73
1
275
195
348
144
53
317
238
551










Molecular Recognition Features






MoRF SequenceStartStop




NANANA