<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP15731

Description mediator of RNA polymerase II transcription subunit 12 isoform X1
SequenceMAAFGMLSYEHRPLKRPRLGPPDVYPQDPKQKEDELTALNVKQGFNNQPAVSGDEHGSAKNVNFNPSKISSNFSSIIAEKLRCNTFPDTGKRKPQVNQKDNFWLVTARSQSSINNWFTDLAGTKPLTQLAKKVPIFSKKEEVFGYLAKYSVPVMRSAWMIKMTCAYHAAITETKVKKRHVIDACIEWTQIITKYLCEQLQKVAEFYRQSPSQGCGSPLPAPPSEVETAMKQWEYNEKLAMFMFQDGMLDRHEFLTWVLECFEKIRPGEDELLKLLLPLLLQYSGEFVQSAYLSRRLAYFCTRRLNLLLSDGSIGPSSGGHPTHGITGQPGNALPTTPTSQPAGATQPQTPFTDFYICPQHRPVVFGLSCMLQSIVLCCPSALVWHYSLTDSRNKTGSPLDLLPIAPSNLPMPGANSTFNQQVRAKVREIEEQIKERGQAVEFRWSFDKCQETTAGFTIGRVLHTLEVLDNHSFEKSDFSNSLDSLYNRIFGSGQSKDGHELSPDDDAVVTLLCEWAVCCKRSGRHRAMVVAKLLEKRQTEIEAERCGESEVVDEKGSVSSGSLSAATLPVFQDVLLQFLDTQAPILTEPGNESERVEFSNLVLLFCELIRHDVFSHNIYMCTLISRGDLASDSHLPRPRSPSDEPSDESERKEQDTGSGVKMEDTGLSEPMEIDNNSSANFDEMLSPPMHCEAKGSPSPEKAAPEQDGKGTAKEKGLDPTFPQVYEQPRHIQYATHFPIPQEESASHECNQRLVVLYGVGKQRDEARHAIKKITKDILKVLNRKSTAETGGEEGQKRKRSKPEAFPTAEDIFSKFQHLSHFDQHQVTSQVSRNVLEQITSFALGMSYHLPLVQHIQFIFDLMEYSLNISGLIDFAIQLLNELSLVEAELLLKSSSLAGSYTTSLCLCIVAVLRRYHSCLILNPDQTAQVFDGLRIVVKSGVNPADCSSAERCILAYLYDLYTSCSHLKSKFGEIFSEFCSKVKNSIYWNIDPSDSNMLWDQVFMIDAIANPSAHNLNHSMVGKILNDSPANRYSFVCNVLMDVCVDHRDPERVNDIGILCAELTAYCRSLSAEWLGVLKALCCSSNNGNCGFNDLLCNVDVSDLSFHDSLATFVAILIARQCLLLEDLVRCVAIPSLLNAACSEQDSEPGARLTCRILLHLFRTPQRNPCPQDSKTDKAAVGIRSSCDRHLLAASQNSIVVGAVFAVLKAVFMLGDAELKGSGFSHPAGLDDIGEDDMGSKKSGGRNISIETASLDVYAKYVLKSICQQEWVGERCLKSLSEDSSALQDPVLVNIQAQRLLQLICYPHRQLDSEEGENPQRQRIKRILQNLDQWTMRQSSLELQLMIKQSSNNELYSLLENIAKATIEVFQKSAEMNSSNPSWNGSAASSSSVSNSNNTSKLKPVLSSSERSGVWLVAPLIAKLPTSVQGHVLKAAGEELEKGQHLGSSSRKERDRQKQKSMSLLSQQPFLSLVLTCLKGQDEQREGLLTSLYSQVQQIVTNWREDQYQDDCKAKQMMHEALKLRLNLVGGMFDTVQRSTQQTTEWAVLLLDIISSGTVDMQSNNELFTTVLDMLSVLINGTLAADMSSISQGGMEENKRAYMNLVKKLRKELGDRQSESLEKVRQLLPLPKQTRDVITCEPQGSLIDTKGNKIAGFEKEGLQVSTKQKISPWDVFEGLKHSAPLSWGWFGTVRVDRKVTRFEEQQRLLLYHTHLKPKPRSYYLEPLPLPPEEEEPPTPVPQEPEKKMVEAVKTDKSVPSVGAEPGKKKSKKKKTSSVNKPEDYTLRNPGVMAFPGSGMNPELMNMSQANHSYRPMHYNQTPIMYTQNQPLPPGGPGLEPPYRPRMPLNNPQKIMSTRSNYPGMISNLQGMMGMDNKQYALGFKPQPAMPQGQIRQQLQVRLNQSMIGQQMRPMVPNQPYTSMQQPQNISQGYTSYTSHVGMQPHPSQAGGIVPASYNNQGFPGAHPGPNPGVVDPLRQMQQRPPGYVHQQAPGAYTTNMPNTPRFPHQGMSQTPMMHSLGQGHLQAQGMHPNMRTNQMLDQQQQQVVQQQQQQQQQQQQYMRQQALRQQAQQQVQQQQQQVQQQQVPSQQVQQSQQVQQQQVQQQQQQVGTAQPPGQPQSQALGMQPLPPQQPMFPRQGQGMQQTQQQQQTAALVRQLQQQLSSTQPGQNTNSYYPKYE
Length2180
PositionKinase
OrganismIctalurus punctatus (Channel catfish) (Silurus punctatus)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Actinopterygii> Neopterygii> Teleostei> Ostariophysi> Siluriformes> Ictaluridae> Ictalurus.
Aromaticity0.07
Grand average of hydropathy-0.524
Instability index56.36
Isoelectric point6.85
Molecular weight243864.13
Publications









Function






Annotated function


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
beta-catenin binding	GO:0008013	IEA:InterPro
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP15731
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             7|     189.84|      17|      25|    2043|    2059|       1
---------------------------------------------------------------------------
 1910- 1927 (25.25/ 9.04)	Q....MRP...MVPNQPyTS........MQQPQ
 2012- 2028 (24.49/ 8.51)	S....QTP...MMHSLG.QG........HLQAQ
 2043- 2059 (33.79/14.99)	Q....QQQ...VVQQQQ.QQ........QQQQQ
 2070- 2086 (32.64/14.19)	Q....AQQ...QVQQQQ.QQ........VQQQQ
 2097- 2122 (23.92/ 8.12)	Q...vQQQ...QVQQQQ.QQvgtaqppgQPQSQ
 2127- 2147 (28.10/11.03)	QplppQQP...MFPRQG.QG........MQQTQ
 2148- 2167 (21.65/ 6.53)	Q....QQQtaaLVRQLQ.QQ........LSSTQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     110.83|      34|      49|     632|     667|       2
---------------------------------------------------------------------------
  632-  667 (53.79/38.06)	DSHLPRPR..SPSDEPSDESERKEQDtGSGVKMEdTGL
  682-  717 (57.04/31.59)	DEMLSPPMhcEAKGSPSPEKAAPEQD.GKGTAKE.KGL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     317.65|      93|     102|    1636|    1737|       3
---------------------------------------------------------------------------
 1628- 1687 (85.84/42.52)	...................................................LPLP...K..QTRDVITCEPQGSLIDT.KGNK.IAGFEKE.GLQVSTKQKISPWDVFEGLKHSAPLSW
 1688- 1792 (133.01/94.28)	GWFG......TvRVDRKVTRFEEQQRllLYhthlkpKPRSY......YLEPLPLPPEEE..EPPTPVPQEPEKKMVEAvKTDKsVPSVGAEpGKKKSKKKKTSSVNKPEDYTLRNPGVM
 1793- 1841 (43.72/18.59)	AFPG......S.GMNPELMNMSQANH..SY......RPMHYnqtpimYTQNQPLPPGGPglEPP.......................................................
 1961- 2011 (55.08/25.65)	GFPGahpgpnP.GVVDPLRQMQQ.............RPPGY......VHQQAPGAYTTN..MPNT..PRFPHQGM............................................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     153.55|      51|      57|    1035|    1091|       8
---------------------------------------------------------------------------
 1035- 1091 (75.76/78.57)	FVCNVlmDVC.VDHRDpERVNDIGIL....CAELTAYCRSLSAEwlGVLKAlCCSSNNGNCG
 1095- 1150 (77.80/54.52)	LLCNV..DVSdLSFHD.SLATFVAILiarqCLLLEDLVRCVAIP..SLLNA.ACSEQDSEPG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      63.72|      23|      25|    1537|    1561|       9
---------------------------------------------------------------------------
 1537- 1561 (33.60/30.93)	QRSTQQTTewAVL.LLDIISSGTV..DM
 1562- 1587 (30.12/18.76)	QSNNELFT..TVLdMLSVLINGTLaaDM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      51.03|      16|      26|    1452|    1467|      10
---------------------------------------------------------------------------
 1452- 1467 (27.47/15.27)	KERDRQKQKSM.SLLSQ
 1479- 1495 (23.56/12.02)	KGQDEQREGLLtSLYSQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      27.04|       8|      77|    1951|    1960|      14
---------------------------------------------------------------------------
 1932- 1939 (15.68/ 8.49)	G..YTSYTSH
 1951- 1960 (11.37/12.41)	GivPASYNNQ
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP15731 with Med12 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) ASDSHLPRPRSPSDEPSDESERKEQDTGSGVKMEDTGLSEPMEIDNNSSANFDEMLSPPMHCEAKGSPSPEKAAPEQDGKGTAKEKGLDPTFPQVYEQPRHIQYATHFPIPQEESA
2) DNKQYALGFKPQPAMPQGQIRQQLQVRLNQSMIGQQMRPMVPNQPYTSMQQPQNISQGYTSYTSHVGMQPHPSQAGGIVPASYNNQGFPGAHPGPNPGVVDPLRQMQQRPPGYVHQQAPGAYTTNMPNTPRFPHQGMSQTPMMHSLGQGHLQAQGMHPNMRTNQMLDQQQQQVVQQQQQQQQQQQQYMRQQALRQQ
3) KRPRLGPPDVYPQDPKQKEDELTALNVKQGFNNQPAVSGDEHGSAKNVNF
4) QQQQQQVGTAQPPGQPQSQALGMQPLPPQQPMFPRQGQGMQQTQQ
5) SYYLEPLPLPPEEEEPPTPVPQEPEKKMVEAVKTDKSVPSVGAEPGKKKSKKKKTSSVNKPEDYTLRNPGVMAFPGSGMNPELMNMSQANHSYRPMHYNQTPIMYTQNQPLPPGGPGLEPPYRPRMPLNNPQKIMSTRSNYPGMISNLQ
630
1875
15
2104
1721
745
2070
64
2148
1869










Molecular Recognition Features






MoRF SequenceStartStop




1) TNSYYPKYE
2172
2180