<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP15729

Description mediator of RNA polymerase II transcription subunit 12 isoform X3
SequenceMAAFGMLSYEHRPLKRPRLGPPDVYPQDPKQKEDELTALNVKQGFNNQPAVSGDEHGSAKNVNFNPSKISSNFSSIIAEKLRCNTFPDTGKRKPQVNQKDNFWLVTARSQSSINNWFTDLAGTKPLTQLAKKVPIFSKKEEVFGYLAKYSVPVMRSAWMIKMTCAYHAAITETKVKKRHVIDACIEWTQIITKYLCEQLQKVAEFYRQSPSQGCGSPLPAPPSEVETAMKQWEYNEKLAMFMFQDGMLDRHEFLTWVLECFEKIRPGEDELLKLLLPLLLQYSGEFVQSAYLSRRLAYFCTRRLNLLLSDGSIGPSSGGHPTHGITGQPGNALPTTPTSQPAGATQPQTPFTDFYICPQHRPVVFGLSCMLQSIVLCCPSALVWHYSLTDSRNKTGSPLDLLPIAPSNLPMPGANSTFNQQVRAKVREIEEQIKERGQAVEFRWSFDKCQETTAGFTIGRVLHTLEVLDNHSFEKSDFSNSLDSLYNRIFGSGQSKDGHELSPDDDAVVTLLCEWAVCCKRSGRHRAMVVAKLLEKRQTEIEAERCGESEVVDEKGSVSSGSLSAATLPVFQDVLLQFLDTQAPILTEPGNESERVEFSNLVLLFCELIRHDVFSHNIYMCTLISRGDLASDSHLPRPRSPSDEPSDESERKEQDTGSGVKMEDTGLSEPMEIDNNSSANFDEMLSPPMHCEAKGSPSPEKAAPEQDGKGTAKEKGLDPTFPQVYEQPRHIQYATHFPIPQEESASHECNQRLVVLYGVGKQRDEARHAIKKITKDILKVLNRKSTAETGGEEGQKRKRSKPEAFPTAEDIFSKFQHLSHFDQHQVTSQVSRNVLEQITSFALGMSYHLPLVQHIQFIFDLMEYSLNISGLIDFAIQLLNELSLVEAELLLKSSSLAGSYTTSLCLCIVAVLRRYHSCLILNPDQTAQVFDGLRIVVKSGVNPADCSSAERCILAYLYDLYTSCSHLKSKFGEIFSEFCSKVKNSIYWNIDPSDSNMLWDQVFMIDAIANPSAHNLNHSMVGKILNDSPANRYSFVCNVLMDVCVDHRDPERVNDIGILCAELTAYCRSLSAEWLGVLKALCCSSNNGNCGFNDLLCNVDVSDLSFHDSLATFVAILIARQCLLLEDLVRCVAIPSLLNAACSEQDSEPGARLTCRILLHLFRTPQRNPCPQDSKTDKAAVGIRSSCDRHLLAASQNSIVVGAVFAVLKAVFMLGDAELKGSGFSHPAGLDDIGEDDMGSKKSGGRNISIETASLDVYAKYVLKSICQQEWVGERCLKSLSEDSSALQDPVLVNIQAQRLLQLICYPHRQLDSEEGENPQRQRIKRILQNLDQWTMRQSSLELQLMIKQSSNNELYSLLENIAKATIEVFQKSAEMNSSNPSWNGSAASSSSVSNSNNTSKLKPVLSSSERSGVWLVAPLIAKLPTSVQGHVLKAAGEELEKGQHLGSSSRKERDRQKQKSMSLLSQQPFLSLVLTCLKGQDEQREGLLTSLYSQVQQIVTNWREDQYQDDCKAKQMMHEALKLRLNLVGGMFDTVQRSTQQTTEWAVLLLDIISSGTVDMQSNNELFTTVLDMLSVLINGTLAADMSSISQGGMEENKRAYMNLVKKLRKELGDRQSESLEKVRQLLPLPKQTRDVITCEPQGSLIDTKGNKIAGFEKEGLQVSTKQKISPWDVFEGLKHSAPLSWGWFGTVRVDRKVTRFEEQQRLLLYHTHLKPKPRSYYLEPLPLPPEEEEPPTPVPQEPEKKMVEAVKTDKSVPSVGAEPGKKKSKKKKTSSVNKPEDYTLRNPGVMAFPGSGMNPELMNMSQANHSYRPMHYNQTPIMYTQNQPLPPGGPGLEPPYRPRMPLNNPQKIMSTRSNYPGMISNLQGMMGMDNKQYALGFKPQPAMPQGQIRQQLQSMIGQQMRPMVPNQPYTSMQQPQNISQGYTSYTSHVGMQPHPSQAGGIVPASYNNQGFPGAHPGPNPGVVDPLRQMQQRPPGYVHQQAPGAYTTNMPNTPRFPHQGMSQTPMMHSLGQGHLQAQGMHPNMRTNQMLDQQQQQVVQQQQQQQQQQQQYMRQQALRQQAQQQVQQQQQQVQQQQVPSQQVQQSQQVQQQQVQQQQQQVGTAQPPGQPQSQALGMQPLPPQQPMFPRQGQGMQQTQQQQQTAALVRQLQQQLSSTQPGQNTNSYYPKYE
Length2175
PositionKinase
OrganismIctalurus punctatus (Channel catfish) (Silurus punctatus)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Actinopterygii> Neopterygii> Teleostei> Ostariophysi> Siluriformes> Ictaluridae> Ictalurus.
Aromaticity0.07
Grand average of hydropathy-0.523
Instability index56.54
Isoelectric point6.79
Molecular weight243253.43
Publications









Function






Annotated function


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
beta-catenin binding	GO:0008013	IEA:InterPro
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP15729
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             7|     260.33|      26|      26|    2029|    2054|       1
---------------------------------------------------------------------------
 1906- 1934 (29.17/ 7.97)	MR..PMVPNQ.....PY...TSMQQPQNISQgytsytSH
 1966- 1994 (28.68/ 7.71)	PGVVDPLRQM....QQRppgYVHQQAPGAYT......TN
 1995- 2024 (31.20/ 9.02)	MPNTPRFPHQgmsqTPM...MHSLGQGHLQA......QG
 2025- 2054 (47.31/17.41)	MRTNQMLDQQ....QQQ...VVQQQQQQQQQ......QQ
 2057- 2081 (43.87/15.62)	MR.QQALRQQ....AQQ...QVQQQQQQVQQ......QQ
 2084- 2104 (36.13/11.59)	S...QQV.QQ....SQQ...V.QQQQVQQQQ......QQ
 2121- 2143 (43.97/15.67)	M...QPLPPQ....QPM...FPRQGQGMQQT......QQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     110.83|      34|      49|     632|     667|       2
---------------------------------------------------------------------------
  632-  667 (53.79/39.34)	DSHLPRPR..SPSDEPSDESERKEQDtGSGVKMEdTGL
  682-  717 (57.04/32.65)	DEMLSPPMhcEAKGSPSPEKAAPEQD.GKGTAKE.KGL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     275.31|      50|      51|    1800|    1849|       3
---------------------------------------------------------------------------
 1718- 1766 (33.15/10.53)	.......KPRSY......YLEPLP..LPP..EEEEPPTpVPQEPEKkmveavktdksvpsvgaEP....G
 1767- 1806 (53.01/21.36)	KKKSKKKKTSSVNK.PEDYTLRNPgvMAFPGSGM.............................NPELMNM
 1807- 1856 (98.00/45.89)	SQANHSYRPMHYNQTPIMYTQNQP..LPPGGPGLEPPY.RPRMPLN.................NPQKIMS
 1857- 1901 (64.38/27.56)	TRSN..YPGMISNLQGMMGMDNKQ..Y...ALGFKP...QPAMPQG...............qiRQQLQSM
 1942- 1963 (26.76/ 7.04)	SQAG.GIVPASYN........NQG..FPGAHPG.....................................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     467.07|     156|     167|    1315|    1481|       5
---------------------------------------------------------------------------
 1316- 1479 (234.70/201.18)	GENPQRQRI.....KRILQNLDQWtmRQSSLELQLMIKQSSNNELySLLENIAKATIEVFQKSAEMNSSNPSWNGSAASSSSVSNSNNTSKLKPVLsssERSGVWLVAPLIAKLPTSVQGHVL..KAAGEELEKG..QHLG..SSSRKERDRQ....KQKSMSLLSQQPFLSLVLTclK
 1480- 1650 (232.37/173.41)	GQDEQREGLltslySQVQQIVTNW..REDQYQDDCKAKQMMHEAL.KLRLNLVGGMFDTVQRSTQQTTEWAVLLLDIISSGTVDMQSNNELFTTVL...DMLSVLINGTLAADMSSISQGGMEenKRAYMNLVKKlrKELGdrQSESLEKVRQllplPKQTRDVITCEPQGSLIDT..K
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     168.09|      52|     326|     243|     301|       6
---------------------------------------------------------------------------
  243-  301 (76.58/78.09)	FQDGMLDRHEFLTWVLecfekIRPGEDELLKLLLPLLLQYSgEFVQSAYLSRRLaYFCT
  571-  622 (91.50/66.55)	FQDVLLQFLDTQAPIL.....TEPGNESERVEFSNLVLLFC.ELIRHDVFSHNI.YMCT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      46.34|      12|      43|     907|     918|       8
---------------------------------------------------------------------------
  907-  918 (25.09/17.18)	CIVAVLRR.YHSC
  952-  964 (21.25/13.35)	CILAYLYDlYTSC
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     153.55|      51|      57|    1035|    1091|       9
---------------------------------------------------------------------------
 1035- 1091 (75.76/95.86)	FVCNVlmDVC.VDHRDpERVNDIGIL....CAELTAYCRSLSAEwlGVLKAlCCSSNNGNCG
 1095- 1150 (77.80/66.59)	LLCNV..DVSdLSFHD.SLATFVAILiarqCLLLEDLVRCVAIP..SLLNA.ACSEQDSEPG
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP15729 with Med12 domain of Kingdom Metazoa
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