<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP15728

Description mediator of RNA polymerase II transcription subunit 12 isoform X2
SequenceMAAFGMLSYEHRPLKRPRLGPPDVYPQDPKQKEDELTALNVKQGFNNQPAVSGDEHGSAKNVNFNPSKISSNFSSIIAEKLRCNTFPDTGKRKPQVNQKDNFWLVTARSQSSINNWFTDLAGTKPLTQLAKKVPIFSKKEEVFGYLAKYSVPVMRSAWMIKMTCAYHAAITETKVKKRHVIDACIEWTQIITKYLCEQLQKVAEFYRQSPSQGCGSPLPAPPSEVETAMKQWEYNEKLAMFMFQDGMLDRHEFLTWVLECFEKIRPGEDELLKLLLPLLLQYSGEFVQSAYLSRRLAYFCTRRLNLLLSDGSIGPSSGGHPTHGITGQPGNALPTTPTSQPAGATQPQTPFTDFYICPQHRPVVFGLSCMLQSIVLCCPSALVWHYSLTDSRNKTGSPLDLLPIAPSNLPMPGANSTFNQQVRAKVREIEEQIKERGQAVEFRWSFDKCQETTAGFTIGRVLHTLEVLDNHSFEKSDFSNSLDSLYNRIFGSGQSKDGHELSPDDDAVVTLLCEWAVCCKRSGRHRAMVVAKLLEKRQTEIEAERCGESEVVDEKGSVSSGSLSAATLPVFQDVLLQFLDTQAPILTEPGNESERVEFSNLVLLFCELIRHDVFSHNIYMCTLISRGDLASDSHLPRPRSPSDEPSDESERKEQDTGSGVKMEDTGLSEPMEIDNNSSANFDEMLSPPMHCEAKGSPSPEKAAPEQDGKGTAKEKGLDPTFPQVYEQPRHIQYATHFPIPQEESASHECNQRLVVLYGVGKQRDEARHAIKKITKDILKVLNRKSTAETGGEEGQKRKRSKPEAFPTAEDIFSKFQHLSHFDQHQVTSQVSRNVLEQITSFALGMSYHLPLVQHIQFIFDLMEYSLNISGLIDFAIQLLNELSLVEAELLLKSSSLAGSYTTSLCLCIVAVLRRYHSCLILNPDQTAQVFDGLRIVVKSGVNPADCSSAERCILAYLYDLYTSCSHLKSKFGEIFSEFCSKVKNSIYWNIDPSDSNMLWDQVFMIDAIANPSAHNLNHSMVGKILNDSPANRYSFVCNVLMDVCVDHRDPERVNDIGILCAELTAYCRSLSAEWLGVLKALCCSSNNGNCGFNDLLCNVDVSDLSFHDSLATFVAILIARQCLLLEDLVRCVAIPSLLNAACSEQDSEPGARLTCRILLHLFRTPQRNPCPQDSKTDKAAVGIRSSCDRHLLAASQNSIVVGAVFAVLKAVFMLGDAELKGSGFSHPAGLDDIGEDDMGSKKSGGRNISIETASLDVYAKYVLKSICQQEWVGERCLKSLSEDSSALQDPVLVNIQAQRLLQLICYPHRQLDSEEGENPQRQRIKRILQNLDQWTMRQSSLELQLMIKQSSNNELYSLLENIAKATIEVFQKSAEMNSSNPSWNGSAASSSSVSNSNNTSKLKPVLSSSERSGVWLVAPLIAKLPTSVQGHVLKAAGEELEKGQHLGSSSRKERDRQKQKSMSLLSQQPFLSLVLTCLKGQDEQREGLLTSLYSQVQQIVTNWREDQYQDDCKAKQMMHEALKLRLNLVGGMFDTVQRSTQQTTEWAVLLLDIISSGTVDMQSNNELFTTVLDMLSVLINGTLAADMSSISQGGMEENKRAYMNLVKKLRKELGDRQSESLEKVRQLLPLPKQTRDVITCEPQGSLIDTKGNKIAGFEKEGLQVSTKQKISPWDVFEGLKHSAPLSWGWFGTVRVDRKVTRFEEQQRLLLYHTHLKPKPRSYYLEPLPLPPEEEEPPTPVPQEPEKKMVEAVKTDKSVPSVGAEPGKKKSKKKKTSSVNKPEDYTLRNPGVMAFPGSGMNPELMNMSQANHSYRPMHYNQTPIMYTQNQPLPPGGPGLEPPYRPRMPLNNPQKIMSTRSNYPGMISNLQGMMGMDNKQYALGFKPQPAMPQGQIRQQLQVRLSMIGQQMRPMVPNQPYTSMQQPQNISQGYTSYTSHVGMQPHPSQAGGIVPASYNNQGFPGAHPGPNPGVVDPLRQMQQRPPGYVHQQAPGAYTTNMPNTPRFPHQGMSQTPMMHSLGQGHLQAQGMHPNMRTNQMLDQQQQQVVQQQQQQQQQQQQYMRQQALRQQAQQQVQQQQQQVQQQQVPSQQVQQSQQVQQQQVQQQQQQVGTAQPPGQPQSQALGMQPLPPQQPMFPRQGQGMQQTQQQQQTAALVRQLQQQLSSTQPGQNTNSYYPKYE
Length2178
PositionKinase
OrganismIctalurus punctatus (Channel catfish) (Silurus punctatus)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Actinopterygii> Neopterygii> Teleostei> Ostariophysi> Siluriformes> Ictaluridae> Ictalurus.
Aromaticity0.07
Grand average of hydropathy-0.521
Instability index56.24
Isoelectric point6.85
Molecular weight243621.90
Publications









Function






Annotated function


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
beta-catenin binding	GO:0008013	IEA:InterPro
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP15728
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             6|     222.77|      25|      25|    2032|    2056|       1
---------------------------------------------------------------------------
 1940- 1959 (29.84/ 7.82)	M...QPHPSQAGGIVPA..SYNNQ..G
 1960- 1984 (28.74/ 7.28)	FPGAHPG..PNPGVVDPLRQMQQRppG
 2032- 2056 (48.18/16.86)	MRTNQMLDQQQQQVVQQQQQQQQQ..Q
 2060- 2083 (42.62/14.12)	MR.QQALRQQAQQQVQQQQQQVQQ..Q
 2084- 2107 (38.13/11.91)	QVPSQQV.QQSQQVQQQQVQQQQQ..Q
 2124- 2144 (35.25/10.49)	M...QPLPPQQPMFPRQGQGMQQT...
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     110.83|      34|      49|     632|     667|       2
---------------------------------------------------------------------------
  632-  667 (53.79/35.32)	DSHLPRPR..SPSDEPSDESERKEQDtGSGVKMEdTGL
  682-  717 (57.04/29.31)	DEMLSPPMhcEAKGSPSPEKAAPEQD.GKGTAKE.KGL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     261.59|      49|      57|    1816|    1864|       3
---------------------------------------------------------------------------
 1723- 1760 (38.14/15.12)	........................YLEPLP..LPPE.............EE..EP..P....TPVpQEPEKKMveavKTDKSVPS
 1761- 1815 (44.26/18.91)	VgaepgkkkskkkktSSVNK.PEDYTLRNPgvMAFP.............GSGMNP..EL.....M.NMSQANH....SYR...P.
 1816- 1863 (91.88/48.45)	...............MHYNQTPIMYTQNQP..LPPG.............GPGLEP..PYRPRMPL.NNPQKIM....STRSNYPG
 1864- 1936 (58.72/27.88)	M.....isnlqgmmgMDNKQYALGF.KPQP.aMPQGqirqqlqvrlsmiGQQMRPmvPNQPYTSM.QQPQNIS....QGYTSYTS
 1985- 2005 (28.59/ 9.19)	Y..............VH.QQAPGAYTTN..........................M..PNTPRFP.....................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     122.22|      40|      50|    1444|    1485|      13
---------------------------------------------------------------------------
 1444- 1485 (60.62/44.22)	QHLGSSSRKERDRQKQKSMSLLSQQpfLSLVLTCLKGQ.DE.QR
 1497- 1538 (61.60/37.65)	QQIVTNWREDQYQDDCKAKQMMHEA..LKLRLNLVGGMfDTvQR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     153.55|      51|      57|    1035|    1091|      14
---------------------------------------------------------------------------
 1035- 1091 (75.76/75.45)	FVCNVlmDVC.VDHRDpERVNDIGIL....CAELTAYCRSLSAEwlGVLKAlCCSSNNGNCG
 1095- 1150 (77.80/52.38)	LLCNV..DVSdLSFHD.SLATFVAILiarqCLLLEDLVRCVAIP..SLLNA.ACSEQDSEPG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      42.66|      14|      15|    1649|    1663|      15
---------------------------------------------------------------------------
 1649- 1663 (20.41/17.16)	TKgNKIAGFEK.EGLQ
 1666- 1680 (22.26/12.72)	TK.QKISPWDVfEGLK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     168.09|      52|     320|     243|     301|      17
---------------------------------------------------------------------------
  243-  301 (76.58/65.31)	FQDGMLDRHEFLTWVLecfekIRPGEDELLKLLLPLLLQYSgEFVQSAYLSRRLaYFCT
  571-  622 (91.50/55.65)	FQDVLLQFLDTQAPIL.....TEPGNESERVEFSNLVLLFC.ELIRHDVFSHNI.YMCT
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP15728 with Med12 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) ASDSHLPRPRSPSDEPSDESERKEQDTGSGVKMEDTGLSEPMEIDNNSSANFDEMLSPPMHCEAKGSPSPEKAAPEQDGKGTAKEKGLDPTFPQVYEQPRHIQYATHFPIPQEESA
2) DNKQYALGFKPQPAMPQGQIRQQLQVRLSMIGQQMRPMVPNQPYTSMQQPQNISQGYTSYTSHVGMQPHPSQAGGIVPASYNNQGFPGAHPGPNPGVVDPLRQMQQRPPGYVHQQAPGAYTTNMPNTPRFPHQGMSQTPMMHSLGQGHLQAQGMHPNMRTNQMLDQQQQQVVQQQQQQQQQQQQYMRQQALRQQ
3) KRPRLGPPDVYPQDPKQKEDELTALNVKQGFNNQPAVSGDEHGSAKNVNF
4) QQQQQQVGTAQPPGQPQSQALGMQPLPPQQPMFPRQGQGMQQTQQ
5) SYYLEPLPLPPEEEEPPTPVPQEPEKKMVEAVKTDKSVPSVGAEPGKKKSKKKKTSSVNKPEDYTLRNPGVMAFPGSGMNPELMNMSQANHSYRPMHYNQTPIMYTQNQPLPPGGPGLEPPYRPRMPLNNPQKIMSTRSNYP
630
1875
15
2102
1721
745
2068
64
2146
1862










Molecular Recognition Features






MoRF SequenceStartStop




1) TNSYYPKYE
2170
2178