<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP15726

Description mediator of RNA polymerase II transcription subunit 26 isoform X2
SequenceMTMTTASVTVTAQQIRDRLLQATDAHCNETRLGKLINDLRKKTRDEDLAKRAKKLLRNWQKLIDPHQPEILPKELSSTLNSVMGSNRSQPLPGSRSPQSATDNDKKPVLHSVRSSSTEKFYPMTHTGKQIVEKNLPTLKGTKRSALSTASGSSGGPDDLQIHSSAIKPHFSSPELNKEPTASAVLRKSVLQQQGQRDITAVEKVKHKSHSHYTNPSPRSVKQLVPSKQPTSISATDSEALSALPLHSSIQGMHTECHQSKDPSQPENESLLNSEKTLEQTNNLQNKSKARPQPGLLSEVTNMETEKDIKPSDGKRRKPQFRDYSINVEGRSTDDMCKPARVKNRKLTFDPLTQQIRPSAVNQSEEQHSSVVDVNEPANLKQSPSASSPNALHKMNWKDMSQNQIVKYYLNLQNNLLKTSGSQVPGAHFFMTEHVKCEEDNMREASKTYVQVPNVSESNLPGIDRDITTDDVHKINNKHWPGVNGCYDSKGHWYGWTECISLDTYGDGSKLNILPYVCMD
Length519
PositionUnknown
OrganismIctalurus punctatus (Channel catfish) (Silurus punctatus)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Actinopterygii> Neopterygii> Teleostei> Ostariophysi> Siluriformes> Ictaluridae> Ictalurus.
Aromaticity0.04
Grand average of hydropathy-0.895
Instability index60.92
Isoelectric point9.10
Molecular weight57918.31
Publications









Function






Annotated function


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP15726
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     156.15|      26|      28|     215|     240|       1
---------------------------------------------------------------------------
   57-   79 (26.21/10.34)	...RNWQKL.ID.PHQPEILPKELSSTL
   85-  108 (22.34/ 7.77)	.SNRS..QP.LPgSRSPQSATDNDKKPV
  122-  146 (33.26/15.02)	PMTHTGKQI.VE.KNLPT.LKGTKRSAL
  215-  240 (41.73/20.65)	PSPRSVKQL.VP.SKQPTSISATDSEAL
  244-  270 (32.60/14.58)	PLHSSIQGMhTE.CHQSKDPSQPENESL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      71.70|      21|     157|     281|     312|       2
---------------------------------------------------------------------------
  290-  310 (37.16/35.55)	RPQPGLLSEVTNME...TEKDIKP
  315-  338 (34.54/ 9.85)	RRKPQFRDYSINVEgrsTDDMCKP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      48.87|      16|     202|     162|     182|       7
---------------------------------------------------------------------------
  162-  179 (24.61/19.45)	HSSAIkpHFSSP.ELNKEP
  367-  383 (24.26/ 8.93)	HSSVV..DVNEPaNLKQSP
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP15726 with Med26 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) KLLRNWQKLIDPHQPEILPKELSSTLNSVMGSNRSQPLPGSRSPQSATDNDKKPVLHSVRSSSTEKFYPMTHTGKQIVEKNLPTLKGTKRSALSTASGSSGGPDDLQIHSSAIKPHFSSPELNKEPTASAVLRKSVLQQQGQRDITAVEKVKHKSHSHYTNPSPRSVKQLVPSKQPTSISATDSEALSALPLHSSIQGMHTECHQSKDPSQPENESLLNSEKTLEQTNNLQNKSKARPQPGLLSEVTNMETEKDIKPSDGKRRKPQFRDYSINVEGRSTDDMCKPARVKNRKLTFDPLTQQIRPSAVNQSEEQHSSVVDVNEPANLKQSPSASSPNALHKMNW
54
396










Molecular Recognition Features






MoRF SequenceStartStop




NANANA