<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP15719

Description mediator of RNA polymerase II transcription subunit 14 isoform X2
SequenceMAPVQIGTEGQLVPVGGPSSAPQPAPGAPATQGVRLSVLIEFLLQRTYHEITLLAELLPRKSDMERKIEIVHFASRTRQLFVRLLALVKWASNAGKVERCAMISAFLDQQAFLFVDTADRLASLARDALVHARLPSFAIPFAIDVLTTGSYPRLPTCIRDKIIPPDPITKAEKQSTLNQLNQILRHRLVTTDLPPQLANLTVANGRVKFRVEGEFEATLTVMGDDPEIPWRLLKLEILVEDKETGDGRALVHSMQVNFIHELVQSRLCADEKPLQDMYNCLHSFCLSLQLEVLHSQTLMLIRERWGDLVQVERYFPAKCLTLSVWNQQVLGRKTGTASVHKVTIKIDETDGSKPLQISHEPPLPACDSKLMERAMKIDHLSVEKLLIDSVHARSYQKLQELKAILKSGNPSDNSFIETALPTLVIPILEPCGRSECLHIFVDLHSGMFQPMLYGIDQSMLDDIEKTINDDMKRIITWLQQLKFWLGEQRCRQSVKHLPTVCTDSLHLSNAASHPVGNLTKHRLFIKLTRLPQYYIVVEMFDIPSNPTELQYKYYFLSVSQPEGEDGLPCALLLQQFKPDLEKLVQDFSSGRLTRPGSKRKLSVEQGAAEPKKPKRSGEMCAFNKELAHLVAMCDTNMPLIGLRCELSNMEIPHQGVQVEGDGCSHAIRLLRVPPAKCVGEETRKALDRSLLDCTFRLQGRNNRTWVAELVFANCPLNSTSTSTRHVYLTYENPLSEPVGGRKVVEMFLNDWNSISQLYECVLEFSRALSEMPSYLNLFSEIRLYNYRKLVLCYGNTKGSSVTIQWNSVTQRFHLALGTVGPNSGCSNCHNIILHQLQEMFNKTPSVVQLLQVLSDTQAPLNAINKLPTVPMLGLTQRTNTAYQCFSILPQSPTHIRLAFRNMYCIDIYCRSRGVVAIRDGAYSLFDNTKIVEGFYPAPGLKTFLNMFVDSNQDARRRSVNEDDNPPSPVGVDVLDTLMPHMQPQQPIRGQGVYPPLTSPNNPYHGGVAPSPSMMPTHSPGNIHAANSPSGALRAPSPFGPTPSPSSLGISMGQTSNFASPHGALDPSSPYPMVSPSQRTGTWPSSPQVSGPSPRMHGMSPGNPSLHSPIPDASHSPRAGTSSQVMPTSMPPPRKLPQRSWAASIPTILTHNALHVLLLPSPTMCLVPGLAGSYLCSPLERFLGSVIMRRHLQRIIQLEPNLTIVNSNEPGVIMFKTEVLKCRVALNPKSYQTLQLKVTPENTGPWSQEELQVLEKFFETRVAGPPFKYNTLNAFTKLLGAPTNILRDCVRIMKLELFPDQAAQLKWNVQFCLTIPPSAPPIAPPGTIAVVLKTKMLFFLQLTQRVPVPQEPISIIVPIVYDMATGLTQQADIPRQHSSSGAAALMVSTILRRFNEHHPARPGECTIFASVHELMANLTLNPGARP
Length1425
PositionTail
OrganismIctalurus punctatus (Channel catfish) (Silurus punctatus)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Actinopterygii> Neopterygii> Teleostei> Ostariophysi> Siluriformes> Ictaluridae> Ictalurus.
Aromaticity0.07
Grand average of hydropathy-0.165
Instability index51.26
Isoelectric point8.67
Molecular weight158356.43
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP15719
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             6|     208.50|      26|      53|    1012|    1037|       1
---------------------------------------------------------------------------
  964-  985 (31.46/11.23)	NPP.SPVGVDVLD.TLM..PHMQ.P.......QQ...........
 1000- 1025 (49.95/22.40)	NNP.YHGGVAPSP.SMM..PTHS.P.......GN..IH.....AA
 1026- 1057 (30.94/10.92)	NSP.SGALRAPSP....fgPTPS.PsslgismGQ..TS.....NF
 1058- 1081 (32.48/11.85)	ASP.HGALDPSSP.....yPMVS.P.......SQ..RT.....GT
 1082- 1113 (33.53/12.49)	WPS.SPQVSGPSP.RMH...GMS.P.......GNpsLHspipdAS
 1114- 1142 (30.13/10.43)	HSPrAGTSSQVMPtSMP..PPRKlP.......QR..SW.....AA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     286.99|     108|     356|     258|     532|       2
---------------------------------------------------------------------------
  274-  332 (63.29/58.17)	.........................................................................LQDMYnCLHSFCLSLQLEVLHSQTLMLirerWGDLVQVERYFPAKCLT..LSVW...NQQVLGR
  474-  532 (59.49/167.80)	IItwLQQLKFWLGEqrcRQSVKHLPTVCTDSLHLSNAASH....PVGNLTK..HRLFIKLTRLPQ........................................................................
  831-  957 (164.22/55.35)	II..LHQLQEMFNK...TPSVVQLLQVLSDTQAPLNAINKlptvPMLGLTQrtNTAYQCFSILPQspthirlaFRNMY.CIDIYCRSRGVVAIRDGAYSL....FDNTKIVEGFYPAPGLKtfLNMFvdsNQDARRR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      50.05|      13|      53|     750|     762|       3
---------------------------------------------------------------------------
  750-  762 (25.31/17.05)	DWNSISQLYECVL
  804-  816 (24.74/16.50)	QWNSVTQRFHLAL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     117.35|      35|      37|    1196|    1232|      11
---------------------------------------------------------------------------
 1196- 1232 (57.35/44.13)	QLE..PNLTIVNSNEPGVIMFKteVLKCRVALNPKSYQT
 1234- 1270 (60.00/39.76)	QLKvtPENTGPWSQEELQVLEK..FFETRVAGPPFKYNT
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP15719 with Med14 domain of Kingdom Metazoa
Unable to open file!