<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP15718

Description mediator of RNA polymerase II transcription subunit 14 isoform X3
SequenceMAPVQIGTEGQLVPVGGPSSAPQPAPGAPATQGVRLSVLIEFLLQRTYHEITLLAELLPRKSDMERKIEIVHFASRTRQLFVRLLALVKWASNAGKVERCAMISAFLDQQAFLFVDTADRLASLARDALVHARLPSFAIPFAIDVLTTGSYPRLPTCIRDKIIPPDPITKAEKQSTLNQLNQILRHRLVTTDLPPQLANLTVANGRVKFRVEGEFEATLTVMGDDPEIPWRLLKLEILVEDKETGDGRALVHSMQVNFIHELVQSRLCADEKPLQDMYNCLHSFCLSLQLEVLHSQTLMLIRERWGDLVQVERYFPAKCLTLSVWNQQVLGRKTGTASVHKVTIKIDETDGSKPLQISHEPPLPACDSKLMERAMKIDHLSVEKLLIDSVHARSYQKLQELKAILKSGNPSDNSFIETALPTLVIPILEPCGRSECLHIFVDLHSGMFQPMLYGIDQSMLDDIEKTINDDMKRIITWLQQLKFWLGEQRCRQSVKHLPTVCTDSLHLSNAASHPVGNLTKHRLFIKLTRLPQYYIVVEMFDIPSNPTELQYKYYFLSVSQPEGEDGLPCALLLQQFKPDLEKLVQDFSSGRLTRPGSKRKLSVEQGAAEPKKPKRSGEMCAFNKELAHLVAMCDTNMPLIGLRCELSNMEIPHQGVQVEGDGCSHAIRLLRVPPAKCVGEETRKALDRSLLDCTFRLQGRNNRTWVAELVFANCPLNSTSSKEQASTRHVYLTYENPLSEPVGGRKVVEMFLNDWNSISQLYECVLEFSRALSEMPSYLNLFSEIRLYNYRKLVLCYGNTKGSSVTIQWNSVTQRFHLALGTVGPNSGCSNCHNIILHQLQEMFNKTPSVVQLLQVLSDTQAPLNAINKLPTVPMLGLTQRTNTAYQCFSILPQSPTHIRLAFRNMYCIDIYCRSRGVVAIRDGAYSLFDNTKIVEGFYPAPGLKTFLNMFVDSNQDARRRSVNEDDNPPSPVGVDVLDTLMPHMQPQQPIRGQGVYPPLTSPNNPYHGGVAPSPSMMPTHSPGALDPSSPYPMVSPSQRTGTWPSSPQVSGPSPRMHGMSPGNPSLHSPIPDASHSPRAGTSSQVMPTSMPPPRKLPQRSWAASIPTILTHNALHVLLLPSPTMCLVPGLAGSYLCSPLERFLGSVIMRRHLQRIIQLEPNLTIVNSNEPGVIMFKTEVLKCRVALNPKSYQTLQLKVTPENTGPWSQEELQVLEKFFETRVAGPPFKYNTLNAFTKLLGAPTNILRDCVRIMKLELFPDQAAQLKWNVQFCLTIPPSAPPIAPPGTIAVVLKTKMLFFLQLTQRVPVPQEPISIIVPIVYDMATGLTQQADIPRQHSSSGAAALMVSTILRRFNEHHPARPGECTIFASVHELMANLTLNPGARP
Length1387
PositionTail
OrganismIctalurus punctatus (Channel catfish) (Silurus punctatus)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Actinopterygii> Neopterygii> Teleostei> Ostariophysi> Siluriformes> Ictaluridae> Ictalurus.
Aromaticity0.07
Grand average of hydropathy-0.166
Instability index50.25
Isoelectric point8.62
Molecular weight154713.46
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP15718
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      46.98|      13|      16|    1028|    1042|       1
---------------------------------------------------------------------------
 1028- 1041 (21.35/ 7.16)	PSSPyPMVSPSQRT
 1045- 1057 (25.63/ 7.31)	PSSP.QVSGPSPRM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      47.12|      11|     264|    1015|    1026|       3
---------------------------------------------------------------------------
   18-   28 (22.16/ 6.21)	PSSAPQPAPGA
 1015- 1025 (24.96/ 8.46)	PSMMPTHSPGA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      84.35|      24|     264|     331|     370|       4
---------------------------------------------------------------------------
  331-  354 (41.03/45.10)	GRKTGTASVHKVTIKIDETDGSKP
 1364- 1387 (43.32/16.07)	GECTIFASVHELMANLTLNPGARP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     135.29|      39|     210|     870|     909|       8
---------------------------------------------------------------------------
  870-  909 (67.82/45.36)	LPTV..PMLGLTQRTNTAyQCFSILPQSPTHIRLAFRNMYCI
 1087- 1127 (67.47/40.09)	MPTSmpPPRKLPQRSWAA.SIPTILTHNALHVLLLPSPTMCL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     132.20|      42|     210|      49|     110|       9
---------------------------------------------------------------------------
   63-  106 (67.91/75.20)	DMERKIEivHFAS.R.TRQLFVRLLALVKWASNAGKVERCAMISAF
  579-  622 (64.30/30.14)	DLEKLVQ..DFSSgRlTRPGSKRKLSVEQGAAEPKKPKRSGEMCAF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     166.05|      48|     149|     280|     328|      11
---------------------------------------------------------------------------
  280-  328 (83.06/70.75)	CLHSFCLSLQLEvLHSQTL..MLIRERWGDLVQVERYFPAKCLTLSVWNQQ
  431-  480 (82.99/65.39)	CGRSECLHIFVD.LHSGMFqpMLYGIDQSMLDDIEKTINDDMKRIITWLQQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     147.37|      49|     795|     355|     410|      12
---------------------------------------------------------------------------
  355-  410 (71.57/56.04)	LQ..ISHEPPLPACDSKlmERAM...KIDHLSVEKLLidsvHARSYQKLQeLKAILKSGNP
 1153- 1206 (75.80/41.52)	LQriIQLEPNLTIVNSN..EPGVimfKTEVLKCRVAL....NPKSYQTLQ.LKVTPENTGP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      85.28|      25|      37|    1217|    1243|      16
---------------------------------------------------------------------------
 1217- 1243 (38.60/28.85)	KFFETRVAgpPFKYNTLNAFTKLLGAP
 1257- 1281 (46.69/27.67)	ELFPDQAA..QLKWNVQFCLTIPPSAP
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP15718 with Med14 domain of Kingdom Metazoa
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