<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP15717

Description mediator of RNA polymerase II transcription subunit 14 isoform X1
SequenceMAPVQIGTEGQLVPVGGPSSAPQPAPGAPATQGVRLSVLIEFLLQRTYHEITLLAELLPRKSDMERKIEIVHFASRTRQLFVRLLALVKWASNAGKVERCAMISAFLDQQAFLFVDTADRLASLARDALVHARLPSFAIPFAIDVLTTGSYPRLPTCIRDKIIPPDPITKAEKQSTLNQLNQILRHRLVTTDLPPQLANLTVANGRVKFRVEGEFEATLTVMGDDPEIPWRLLKLEILVEDKETGDGRALVHSMQVNFIHELVQSRLCADEKPLQDMYNCLHSFCLSLQLEVLHSQTLMLIRERWGDLVQVERYFPAKCLTLSVWNQQVLGRKTGTASVHKVTIKIDETDGSKPLQISHEPPLPACDSKLMERAMKIDHLSVEKLLIDSVHARSYQKLQELKAILKSGNPSDNSFIETALPTLVIPILEPCGRSECLHIFVDLHSGMFQPMLYGIDQSMLDDIEKTINDDMKRIITWLQQLKFWLGEQRCRQSVKHLPTVCTDSLHLSNAASHPVGNLTKHRLFIKLTRLPQYYIVVEMFDIPSNPTELQYKYYFLSVSQPEGEDGLPCALLLQQFKPDLEKLVQDFSSGRLTRPGSKRKLSVEQGAAEPKKPKRSGEMCAFNKELAHLVAMCDTNMPLIGLRCELSNMEIPHQGVQVEGDGCSHAIRLLRVPPAKCVGEETRKALDRSLLDCTFRLQGRNNRTWVAELVFANCPLNSTSSKEQASTRHVYLTYENPLSEPVGGRKVVEMFLNDWNSISQLYECVLEFSRALSEMPSYLNLFSEIRLYNYRKLVLCYGNTKGSSVTIQWNSVTQRFHLALGTVGPNSGCSNCHNIILHQLQEMFNKTPSVVQLLQVLSDTQAPLNAINKLPTVPMLGLTQRTNTAYQCFSILPQSPTHIRLAFRNMYCIDIYCRSRGVVAIRDGAYSLFDNTKIVEGFYPAPGLKTFLNMFVDSNQDARRRSVNEDDNPPSPVGVDVLDTLMPHMQPQQPIRGQGVYPPLTSPNNPYHGGVAPSPSMMPTHSPGNIHAANSPSGALRAPSPFGPTPSPSSLGISMGQTSNFASPHGALDPSSPYPMVSPSQRTGTWPSSPQVSGPSPRMHGMSPGNPSLHSPIPDASHSPRAGTSSQVMPTSMPPPRKLPQRSWAASIPTILTHNALHVLLLPSPTMCLVPGLAGSYLCSPLERFLGSVIMRRHLQRIIQLEPNLTIVNSNEPGVIMFKTEVLKCRVALNPKSYQTLQLKVTPENTGPWSQEELQVLEKFFETRVAGPPFKYNTLNAFTKLLGAPTNILRDCVRIMKLELFPDQAAQLKWNVQFCLTIPPSAPPIAPPGTIAVVLKTKMLFFLQLTQRVPVPQEPISIIVPIVYDMATGLTQQADIPRQHSSSGAAALMVSTILRRFNEHHPARPGECTIFASVHELMANLTLNPGARP
Length1429
PositionTail
OrganismIctalurus punctatus (Channel catfish) (Silurus punctatus)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Actinopterygii> Neopterygii> Teleostei> Ostariophysi> Siluriformes> Ictaluridae> Ictalurus.
Aromaticity0.07
Grand average of hydropathy-0.171
Instability index51.41
Isoelectric point8.67
Molecular weight158798.90
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU365082

GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP15717
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             6|     208.50|      26|      53|    1016|    1041|       1
---------------------------------------------------------------------------
  968-  989 (31.46/10.37)	NPP.SPVGVDVLD.TLM..PHMQ.P.......QQ...........
 1004- 1029 (49.95/20.69)	NNP.YHGGVAPSP.SMM..PTHS.P.......GN..IH.....AA
 1030- 1061 (30.94/10.08)	NSP.SGALRAPSP....fgPTPS.PsslgismGQ..TS.....NF
 1062- 1085 (32.48/10.94)	ASP.HGALDPSSP.....yPMVS.P.......SQ..RT.....GT
 1086- 1117 (33.53/11.53)	WPS.SPQVSGPSP.RMH...GMS.P.......GNpsLHspipdAS
 1118- 1146 (30.13/ 9.63)	HSPrAGTSSQVMPtSMP..PPRKlP.......QR..SW.....AA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      50.05|      13|      53|     754|     766|       2
---------------------------------------------------------------------------
  754-  766 (25.31/19.49)	DWNSISQLYECVL
  808-  820 (24.74/18.85)	QWNSVTQRFHLAL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      63.60|      17|     173|      11|      42|       5
---------------------------------------------------------------------------
   18-   36 (29.44/33.41)	PSSAPQPAPgaPATQGVRL
 1319- 1335 (34.16/ 6.00)	PPSAPPIAP..PGTIAVVL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     139.86|      44|     210|      49|     110|       7
---------------------------------------------------------------------------
   61-  106 (71.27/66.12)	KSDMERKIEivHFAS.R.TRQLFVRLLALVKWASNAGKVERCAMISAF
  577-  622 (68.59/34.44)	KPDLEKLVQ..DFSSgRlTRPGSKRKLSVEQGAAEPKKPKRSGEMCAF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     166.05|      48|     149|     280|     328|      12
---------------------------------------------------------------------------
  280-  328 (83.06/80.90)	CLHSFCLSLQLEvLHSQTL..MLIRERWGDLVQVERYFPAKCLTLSVWNQQ
  431-  480 (82.99/74.78)	CGRSECLHIFVD.LHSGMFqpMLYGIDQSMLDDIEKTINDDMKRIITWLQQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     169.30|      54|     836|     353|     410|      14
---------------------------------------------------------------------------
  353-  410 (79.76/80.82)	KPLQ..ISHEPPLPACDSKlmERAMKIDHLSVEKLLIdSVHARSYQKLQeLKAILKSGNP
 1193- 1248 (89.54/70.74)	RHLQriIQLEPNLTIVNSN..EPGVIMFKTEVLKCRV.ALNPKSYQTLQ.LKVTPENTGP
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP15717 with Med14 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) NQDARRRSVNEDDNPPSPVGVDVLDTLMPHMQPQQPIRGQGVYPPLTSPNNPYHGGVAPSPSMMPTHSPGNIHAANSPSGALRAPSPFGPTPSPSSLGISMGQTSNFASPHGALDPSSPYPMVSPSQRTGTWPSSPQVSGPSPRMHGMSPGNPSLHSPIPDASHSPRAGTSSQVMPTSMPPPRKLPQRSWA
955
1145










Molecular Recognition Features






MoRF SequenceStartStop




NANANA