Description | Mediator of RNA polymerase II transcription subunit 19 |
Sequence | MTEIFSSLYGQTEAQGPSAMGFGPGKPLPPPVPQNPVHMAVPIPHQLVDEGPPLRKPAAMNEPFYLVRELPMETELTGNTNLITHYNLEHAYNKFCGKKVKEKLSNFLPELPGMIDTQGLQDGSSLRSLIEKPPVCNNSFSPLTGTMLTGFRLHTGPLPEQYRLMHIQPPKKKSKHKHRHHRPQDPLPPETPSDSDHKKKKKKKDDDPDRKKKKKDKKKKKNRHSPDHPGTTSSQPSSSSLR |
Length | 242 |
Position | Head |
Organism | Ictalurus punctatus (Channel catfish) (Silurus punctatus) |
Kingdom | Metazoa |
Lineage | Eukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Actinopterygii> Neopterygii> Teleostei> Ostariophysi> Siluriformes> Ictaluridae> Ictalurus. |
Aromaticity | 0.05 |
Grand average of hydropathy | -1.078 |
Instability index | 57.60 |
Isoelectric point | 9.73 |
Molecular weight | 27210.93 |
Publications |
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364151 |
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro |
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro |
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro |
Binary Interactions |
Repeats | >MDP15715 --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 44.65| 13| 18| 196| 208| 1 --------------------------------------------------------------------------- 196- 208 (24.50/10.41) DHKKKKKKK.DDDP 216- 229 (20.16/ 7.27) DKKKKKNRHsPDHP --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 3| 141.64| 32| 114| 42| 74| 2 --------------------------------------------------------------------------- 43- 74 (58.55/18.46) IPHQ..LVDEGPPLR....KPAAMNEPFYLVRELPMET 115- 144 (32.78/ 8.21) IDTQ..GLQDGSSLRslieKPPVCNNSFS.....PLT. 158- 191 (50.31/14.76) LPEQyrLMHIQPPKK....KSKHKHRHHRPQDPLPPET --------------------------------------------------------------------------- |
MoRF Sequence | Start | Stop |
1) DHKKKKKKKDDDPDRKKKKKDKKKKKNRH 2) KKKSKHKH 3) QYRLMHIQP | 196 171 161 | 224 178 169 |
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Designed by Dr. Shailesh Lab & Dr. Jitendra K. Thakur Lab