<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP15710

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMTTAANWVANGASLEDCHSNLFSLAELTGIKWRCYNFRGGGEYGPVISAPAQDDPVLCSFTRCVQANLLCVWRRKLKPDAKELWIFWWGDEPNLSDIIHHELEVVEEGLWECGLSYECRTLLFKAVHNLLERCLMDKDFVRIGKWFVKPYELEEKHLGASSSEHLSCSFSFFLHGESNVCTSVEISQHQPVYHITEEHVRLAQTSSSPIQVILSPYGLGGTLTGQVFKMSDPAVRKLIEEWSYFYPMVLKHSRGEQDSNLSYDPHSHVALEVIVGGVRMIYPAAFVLIAQADLPVEQPPPAQGAQSGTRDSSNCGIPLTPPTSPEQPCSGDSGFQTAVSSVSSQESGATHSPKHSEKKLSNQMVHQAWKECYMNQLQRKCNLSNGMVPKKEVTSEVAVWDFTDPGERAPCSCNRMRQQSKQQQQTNGFSANSQPSTNPSSSSSSSSLSSSLPPPSTPKSKTADKADKSDKVSKRSAITPFHHRLSVDQQPCPEQDAPPGPQLVLAALDTSLDTLPGCKYPKPMFTGRKGPESLLHSPVSPLPPTLSPHPRVQDPEVMEAPMDVSQCLEGTSLPTAPEMSDTALYTASLVPREANGGWWKSYRTPRVDKAELKPPELPYDMVEIKAEGEGTALKSFFAQTHKRFKISEERLQEHMSTLGFLQQPGVEGLGEAGEDPYDFKEGDIEYSFPTTKRLKSRDPSRKSKGEEVNGNSAVPEGKDAMSIFSSAPKFEELAQDESGGKANPPLTREKDLIVLISDLENIFGEEEDDLGTTFPNHQQPSKTVVPGAEERPLGIDGRVAVPYPSTVAELQRMFPTPPSLEQHPAFSPITTYRDTPSQETPAPSAGHEHPLNTHTNNQLNDYRSEMDESMTSPKAEDIRPQMGCSMFAPLRTLPSQCLPPLKIPEQCYYRPSWSMLPKMEPYCLPSQAPFVRDGYVNVPSIGALQDQDYAQMSTGTASVGTAGGVLPSPATPRFSVPTPRTPRTPRGVGTASGQGSIKQDGTELSSPISTPSTGLPLSSVEPLASGPVLPEAHSLYVILLLSDSVLDVFKDRSFDSCCICACNMNVKGADVGIYIPDSTREDQYRCMCGFSAIANRRLAHGAGLFLEDELDIFGRGSEAGRAAERRLALGRRDTPTGGKRAQEQTPMEVLELIQEQCSQPILSVASLHSPAACSCRSRQRALLQSWVADRLWADGSDACVECYNALVQGLQYVDNAAGGKVEQALVRSSALHSWPHTNVLDISMLSSQDVVRMLLSLQPFLQDAIQKKRTGRTWENIQHVQGPLTWQQFHKMAGRGSYGSEESPEPLPIPTLLLGYDRDFLALSPLALPFWEKLLLEPYGGQRDVAFLVLCPDNDILLTGARTFFQELSAVYESCRLGKHHPLARMSRDGIVPVGAMESEKLEENGREVDEWMTGPWAGQYREDHLSKLKLYAQTCKQKLAPQLSALSLDSSLLLPPKPQPSSAPAPSTQLNPGSGAPEGETSATAAAAGVPGSGNTPTSTSTSTGQASTEGADTLQSVPNTTPIQQSHPTESAESLAERERIGIPTAAQSADSHAYPPAIVLYLVDPFLCSGSGVGSGEEEEAEEVESRSMWLLALLRCYTDMLSVLPENIQPALVLQVVPCQYLLQPASGESPLYLQHLRSLAFSAHSQCRRRLPTQTHIKSLTGFGPAATIDSLFKSVENPSSMQVYSPPFVLAPLRTKQPEVGEEATTRYNVLFVGYCLSHDQRWILVSCTDQQGELLETCIINIDVPNRSRRPKFSPRKIGLQKLWEWCIGIIQMTAIPWRIVIGRLGRLGHGELKDWSLLLGEHSLHSISRQLREACRMCGISATDSPSILSACLVSMEPQGSFVVMPDAVTMGSVFGRSTALNLQTSQLNTPQDASCTHILVFPTSSTTQVAPSSYPTEDNPDDIFGLPFTDDLEKDIEHDMMLITGNLHASPNTSPVPSPGSPSGLGVGSHFPHTRSQGERLLSREAPEELKQQPLALGYYVSTAQAEGLPHWFWASCPQAQNQCPLFLKASLHHHISIAQTDELVSSKTSQRNPHPLDSKTTSDVLRFVLEQYNALSWLTCSPATQDRRSCLPVHLVILTQMYNAILNIL
Length2098
PositionMiddle
OrganismIctalurus punctatus (Channel catfish) (Silurus punctatus)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Actinopterygii> Neopterygii> Teleostei> Ostariophysi> Siluriformes> Ictaluridae> Ictalurus.
Aromaticity0.07
Grand average of hydropathy-0.376
Instability index56.90
Isoelectric point5.49
Molecular weight229765.88
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP15710
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      64.58|      18|      22|    1472|    1492|       1
---------------------------------------------------------------------------
 1472- 1489 (31.72/12.51)	PGSGAPEGETSATAAAAG
 1491- 1508 (32.86/21.94)	PGSGNTPTSTSTSTGQAS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      56.71|      17|      22|    1302|    1318|       2
---------------------------------------------------------------------------
 1302- 1318 (34.14/21.35)	SPEPLPI.PTLLL...GYDRD
 1323- 1343 (22.57/11.02)	SPLALPFwEKLLLepyGGQRD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      68.96|      23|      24|     530|     553|       3
---------------------------------------------------------------------------
  530-  553 (40.43/19.66)	PEsLLHSP..VSP.LPPT.LSPHPRVQD
  554-  580 (28.53/ 9.24)	PE.VMEAPmdVSQcLEGTsLPTAPEMSD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      74.17|      20|      20|     893|     912|       4
---------------------------------------------------------------------------
  893-  912 (43.81/24.38)	PSQCLPPLKIPEQCYYRP.......SW
 1159- 1185 (30.36/14.20)	PILSVASLHSPAACSCRSrqrallqSW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      93.38|      19|      22|     436|     457|       5
---------------------------------------------------------------------------
  306-  324 (34.96/ 9.43)	SGTRDSSNCGIPLTPPTSP
  439-  457 (31.95/14.16)	SSSSSSSSLSSSLPPPSTP
  954-  971 (26.47/ 6.91)	.GTASVGTAGGVLPSPATP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      62.90|      20|      23|    1509|    1528|       6
---------------------------------------------------------------------------
 1509- 1528 (35.71/21.93)	TEGADTLQ.....SVPNTTPIQQSH
 1530- 1554 (27.20/14.68)	TESAESLAereriGIPTAAQSADSH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      41.85|      10|      23|     814|     823|       7
---------------------------------------------------------------------------
  814-  823 (21.02/ 9.66)	PTPPSLEQHP
  840-  849 (20.84/ 9.50)	PAPSAGHEHP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      29.30|      11|      22|    1192|    1207|       8
---------------------------------------------------------------------------
 1192- 1207 ( 9.93/23.91)	ADGSdacVEcyNALVQ
 1216- 1226 (19.37/10.68)	AGGK...VE..QALVR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      69.33|      23|      28|    1071|    1098|       9
---------------------------------------------------------------------------
 1071- 1098 (38.75/32.52)	GIYIpdstrEDQYRCMC.GFSA..IANRRLA
 1102- 1127 (30.58/15.04)	GLFL.....EDELDIFGrGSEAgrAAERRLA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      68.00|      22|     806|     867|     891|      11
---------------------------------------------------------------------------
  867-  891 (35.48/25.11)	ESMTSPKAEDI.RPQMgcsMFAPLRT
 1678- 1700 (32.52/14.93)	KSVENPSSMQVySPPF...VLAPLRT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      51.07|      13|      28|     485|     497|      14
---------------------------------------------------------------------------
  485-  497 (25.58/13.30)	SVDQQPCPEQDAP
  510-  522 (25.50/13.23)	SLDTLPGCKYPKP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      56.00|      17|      23|      73|      95|      18
---------------------------------------------------------------------------
   73-   95 (24.25/26.85)	RRKLKPDAKELWifwwgdEPNLS
   99-  115 (31.75/16.00)	HHELEVVEEGLW......ECGLS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      39.18|      11|      22|    1608|    1618|      20
---------------------------------------------------------------------------
 1608- 1618 (19.28/10.25)	PENIQPALVLQ
 1628- 1638 (19.91/10.87)	PASGESPLYLQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     193.68|      61|    1272|     652|     728|      21
---------------------------------------------------------------------------
  663-  728 (93.73/75.87)	PGVEGLGEAGeDPYDFKEGDieySFPTTK....RLKSRDPSRKSKGEEVN.G...NSAVPEGKDAMsIFSSAPK
 1939- 2007 (99.95/47.57)	PNTSPVPSPG.SPSGLGVGS...HFPHTRsqgeRLLSREAPEELKQQPLAlGyyvSTAQAEGLPHW.FWASCPQ
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP15710 with Med13 domain of Kingdom Metazoa
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