<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP15708
Description |
Mediator of RNA polymerase II transcription subunit 1 |
Sequence | MESKVDVLKMTYLSKLSQKYSEKPWSETIQLVHRCMGKSRTDSRHYEPIMRCLQKLQEAQNVTSLSAMVTRLEMIAKQRGLGSHLSPTETACYLTADLFYVEVLLLPGGEVEDVKVAQHGEAPESNASLCQLLRMKKFKEFSLRMGDLASLYNVPGDGDTRLKVLKSLQHLQKDLLKISNLPRHLIASDAHVDLVLNGRIGSITPSKEGNPMSIEYYISPSDAMMERLHPGEGNRSQAAVVVVVGASATTHRLQMESLIPTPPQVDSTGLPAFIPLSETCSELLPAFFLLKMKPPVPMLSSFIHKMSQITDLPPDADLQGEPLFQLLQLTALEDKRSCDGKDALFLVSLPDAEFHSYLFTTAEWKCDFWKGSLIHTVPFTHPAHVPALLDLLRYQSAVNTLLASCITSLKHQPELVCDLSGEIVPESDCSFSVTFSIPDSETLAVLLVSVVNCHQLRCRLLMPGTVDQSLDDYISRVLTRCMSIPITLRAIRKRLSSLRPPALPLEPESARKAVSSSSTPAHCAVENTPAILPPAMLSPEPMEEDGLPSNPGHYVMSVAAAPAVDVANTDAIANRSNCASVSVYSHWVASSFPAELV |
Length | 597 |
Position | Middle |
Organism | Ictalurus punctatus (Channel catfish) (Silurus punctatus) |
Kingdom | Metazoa |
Lineage | Eukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi>
Actinopterygii> Neopterygii> Teleostei> Ostariophysi> Siluriformes>
Ictaluridae> Ictalurus.
|
Aromaticity | 0.06 |
Grand average of hydropathy | -0.031 |
Instability index | 53.48 |
Isoelectric point | 5.89 |
Molecular weight | 65543.99 |
Publications | |
Function
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364059
|
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro
|
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro
|
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro
|
Interaction
Repeat regions
Repeats |
>MDP15708
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 111.94| 36| 155| 132| 172| 1
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132- 172 (52.93/48.12) LLRMK....KFKEFSLRMGDLASLynvPGDGDTRLKVLksLQHLQ
289- 328 (59.01/38.06) LLKMKppvpMLSSFIHKMSQITDL...PPDADLQGEPL..FQLLQ
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 92.71| 29| 31| 500| 530| 2
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500- 530 (43.87/29.85) PPALpLEPESARKAvSSSSTPAH..CAVENTPA
533- 563 (48.84/24.71) PPAM.LSPEPMEED.GLPSNPGHyvMSVAAAPA
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 28.46| 8| 27| 330| 339| 6
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330- 339 (10.87/12.18) TALEDKrsCD
360- 367 (17.59/10.61) TTAEWK..CD
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