<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP15707

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMTTAANWVANGASLEDCHSNLFSLAELTGIKWRCYNFRGGGEYGPVISAPAQDDPVLCSFTRCVQANLLCVWRRKLKPDAKELWIFWWGDEPNLSDIIHHELEVVEEGLWECGLSYECRTLLFKAVHNLLERCLMDKDFVRIGKWFVKPYELEEKHLGASSSEHLSCSFSFFLHGESNVCTSVEISQHQPVYHITEEHVRLAQTSSSPIQVILSPYGLGGTLTGQVFKMSDPAVRKLIEEWSYFYPMVLKHSRGEQDSNLSYDPHSHVALEVIVGGVRMIYPAAFVLIAQADLPVEQPPPAQGAQSGTRDSSNCGIPLTPPTSPEQPCSGDSGFQTAVSSVSSQESGATHSPKHSEKKLSNQMVHQAWKECYMNQLQRKCNLSNGMVPKKEVTSEVAVWDFTDPGERAPCSCNRMRQQSKQQQQTNGFSANSQPSTNPSSSSSSSSLSSSLPPPSTPKSKTADKADKSDKVSKRSAITPFHHRLSVDQQPCPEQDAPPGPQLVLAALDTSLDTLPGCKYPKPMFTGRKGPESLLHSPVSPLPPTLSPHPRVQDPEVMEAPMDVSQCLEGTSLPTAPEMSDTALYTASLVPREANGGWWKSYRTPRVDKAELKPPELPYDMVEIKAEGEGTALKSFFAQTHKRFKISEERLQEHMSTLGFLQQPGVEGLGEAGEDPYDFKEGDIEYSFPTTKRLKSRDPSRKSKGEEVNGNSAVPEGKDAMSIFSSAPKFAEELAQDESGGKANPPLTREKDLIVLISDLENIFGEEEDDLGTTFPNHQQPSKTVVPGAEERPLGIDGRVAVPYPSIAELQRMFPTPPSLEQHPAFSPITTYRDTPSQETPAPSAGHEHPLNTHTNNQLNDYRSEMDESMTSPKAEDIRPQMGCSMFAPLRTLPSQCLPPLKIPEQCYYRPSWSMLPKMEPYCLPSQAPFVRDGYVNVPSIGALQDQDYAQMSTGTASVGTAGGVLPSPATPRFSVPTPRTPRTPRGVGTASGQGSIKQDGTELSSPISTPSTGLPLSSVEPLASGPVLPEAHSLYVILLLSDSVLDVFKDRSFDSCCICACNMNVKGADVGIYIPDSTREDQYRCMCGFSAIANRRLAHGAGLFLEDELDIFGRGSEAGRAAERRLALGRRDTPTGGKRAQEQTPMEVLELIQEQCSQPILSVASLHSPAACSCRSRQRALLQSWVADRLWADGSDACVECYNALVQGLQYVDNAAGGKVEQALVRSSALHSWPHTNVLDISMLSSQDVVRMLLSLQPFLQDAIQKKRTGRTWENIQHVQGPLTWQQFHKMAGRGSYGSEESPEPLPIPTLLLGYDRDFLALSPLALPFWEKLLLEPYGGQRDVAFLVLCPDNDILLTGARTFFQELSAVYESCRLGKHHPLARMSRDGIVPVGAMESEKLEENGREVDEWMTGPWAGQYREDHLSKLKLYAQTCKQKLAPQLSALSLDSSLLLPPKPQPSSAPAPSTQLNPGSGAPEGETSATAAAAGVPGSGNTPTSTSTSTGQASTEGADTLQSVPNTTPIQQSHPTESAESLAERERIGIPTAAQSADSHAYPPAIVLYLVDPFLCSGSGVGSGEEEEAEEVESRSMWLLALLRCYTDMLSVLPENIQPALVLQVVPCQYLLQPASGESPLYLQHLRSLAFSAHSQCRRRLPTQTHIKSLTGFGPAATIDSLFKSVENPSSMQVYSPPFVLAPLRTKQPEVGEEATTRYNVLFVGYCLSHDQRWILVSCTDQQGELLETCIINIDVPNRSRRPKFSPRKIGLQKLWEWCIGIIQMTAIPWRIVIGRLGRLGHGELKDWSLLLGEHSLHSISRQLREACRMCGISATDSPSILSACLVSMEPQGSFVVMPDAVTMGSVFGRSTALNLQTSQLNTPQDASCTHILVFPTSSTTQVAPSSYPTEDNPDDIFGLPFTDDLEKDIEHDMMLITGNLHASPNTSPVPSPGSPSGLGVGSHFPHTRSQGERLLSREAPEELKQQPLALGYYVSTAQAEGLPHWFWASCPQAQNQCPLFLKASLHHHISIAQTDELVSSKTSQRNPHPLDSKTTSDVLRFVLEQYNALSWLTCSPATQDRRSCLPVHLVILTQMYNAILNIL
Length2098
PositionMiddle
OrganismIctalurus punctatus (Channel catfish) (Silurus punctatus)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Actinopterygii> Neopterygii> Teleostei> Ostariophysi> Siluriformes> Ictaluridae> Ictalurus.
Aromaticity0.07
Grand average of hydropathy-0.375
Instability index56.90
Isoelectric point5.49
Molecular weight229749.89
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP15707
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     166.58|      40|      55|     508|     562|       1
---------------------------------------------------------------------------
  508-  544 (54.79/23.04)	...............D.............T.SLDT.LPGCKYPKPMFTgrKGPESLLHSPVSPLPPT
  819-  868 (49.68/18.45)	L.EQHPafspittyrD.............TpSQETpAPSAGHEHPLNT...HTNNQLNDYRSEMDES
  869-  917 (51.72/19.52)	MtSPK...........aedirpqmgcsmfA.PLRT.LPSQCLP.PL....KIPEQCYYRPSWSMLPK
 1454- 1477 (10.40/ 9.25)	L.PPKP.qpssapapS.............T.QLN...PGSGAP........................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      61.96|      17|      22|    1492|    1513|       2
---------------------------------------------------------------------------
  979-  995 (30.84/10.46)	RTPRTPRGVGTASGQGS
 1492- 1508 (31.12/21.12)	GSGNTPTSTSTSTGQAS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      56.71|      17|      22|    1302|    1318|       3
---------------------------------------------------------------------------
 1302- 1318 (34.14/19.37)	SPEPLPI.PTLLL...GYDRD
 1323- 1343 (22.57/ 9.98)	SPLALPFwEKLLLepyGGQRD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      72.42|      21|      23|     434|     456|       4
---------------------------------------------------------------------------
  299-  321 (35.55/11.44)	PPAQGAQSGTRDSSNCGIPltPP
  434-  454 (36.87/17.07)	PSTNPSSSSSSSSLSSSLP..PP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      62.90|      20|      23|    1509|    1528|       5
---------------------------------------------------------------------------
 1509- 1528 (35.71/21.11)	TEGADTLQ.....SVPNTTPIQQSH
 1530- 1554 (27.20/14.15)	TESAESLAereriGIPTAAQSADSH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      47.85|      15|      24|     764|     781|       7
---------------------------------------------------------------------------
  764-  781 (24.35/21.99)	GEEEDDLG....TTFPnhqQPS
  787-  805 (23.51/11.53)	GAEERPLGidgrVAVP...YPS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      56.00|      17|      23|      73|      95|       8
---------------------------------------------------------------------------
   73-   95 (24.25/26.92)	RRKLKPDAKELWifwwgdEPNLS
   99-  115 (31.75/16.05)	HHELEVVEEGLW......ECGLS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      70.23|      21|      22|    1163|    1183|       9
---------------------------------------------------------------------------
 1163- 1183 (37.44/19.54)	VAS.LHSPAACSCRSRQRALLQ
 1186- 1207 (32.80/16.18)	VADrLWADGSDACVECYNALVQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      69.37|      21|      26|    1080|    1100|      10
---------------------------------------------------------------------------
 1080- 1100 (42.06/29.79)	EDQYRCMC.GFSA..IANRRLAHG
 1106- 1129 (27.31/16.49)	EDELDIFGrGSEAgrAAERRLALG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     240.42|      73|    1272|     652|     728|      11
---------------------------------------------------------------------------
  653-  728 (119.67/64.24)	HMSTL.GFLQQPGVEGLGEAGEDPYDFKEGDieYSFPTTK....RLKSRDPSRKSKGEEVN.G...NSAVPEGKDAMsIFSSAPK
 1660- 1692 (31.36/ 6.71)	HIKSLtGFGPAATIDSLFKSVENPSSMQV....YSPP................................................
 1939- 2007 (89.39/39.72)	...........PNTSPVPSPG.SPSGLGVGS...HFPHTRsqgeRLLSREAPEELKQQPLAlGyyvSTAQAEGLPHW.FWASCPQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      85.00|      27|     805|    1224|    1254|      12
---------------------------------------------------------------------------
 1224- 1254 (38.26/30.22)	LVRSSALHSWPHTnvLDISmlSSQDVVRMLL
 2032- 2058 (46.75/24.53)	LVSSKTSQRNPHP..LDSK..TTSDVLRFVL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      39.18|      11|      22|    1608|    1618|      13
---------------------------------------------------------------------------
 1608- 1618 (19.28/10.77)	PENIQPALVLQ
 1628- 1638 (19.91/11.42)	PASGESPLYLQ
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP15707 with Med13 domain of Kingdom Metazoa
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