<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP15706

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMTTAANWVANGASLEDCHSNLFSLAELTGIKWRCYNFRGGGEYGPVISAPAQDDPVLCSFTRCVQANLLCVWRRKLKPDAKELWIFWWGDEPNLSDIIHHELEVVEEGLWECGLSYECRTLLFKAVHNLLERCLMDKDFVRIGKWFVKPYELEEKHLGASSSEHLSCSFSFFLHGESNVCTSVEISQHQPVYHITEEHVRLAQTSSSPIQVILSPYGLGGTLTGQVFKMSDPAVRKLIEEWSYFYPMVLKHSRGEQDSNLSYDPHSHVALEVIVGGVRMIYPAAFVLIAQADLPVEQPPPAQGAQSGTRDSSNCGIPLTPPTSPEQPCSGDSGFQTAVSSVSSQESGATHSPKHSEKKLSNQMVHQAWKECYMNQLQRKCNLSNGMVPKKEVTSEVAVWDFTDPGERAPCSCNRMRQQSKQQQQTNGFSANSQPSTNPSSSSSSSSLSSSLPPPSTPKSKTADKADKSDKVSKRSAITPFHHRLSVDQQPCPEQDAPPGPQLVLAALDTSLDTLPGCKYPKPMFTGRKGPESLLHSPVSPLPPTLSPHPRVQDPEVMEAPMDVSQCLEGTSLPTAPEMSDTALYTASLVPREANGGWWKSYRTPRVDKAELKPPELPYDMVEIKAEGEGTALKSFFAQTHKRFKISEERLQEHMSTLGFLQQPGVEGLGEAGEDPYDFKEGDIEYSFPTTKRLKSRDPSRKSKGEEVNGNSAVPEGKDAMSIFSSAPKFAEELAQDESGGKANPPLTREKDLIVLISDLENIFGEEEDDLGTTFPNHQQPSKTVVPGAEERPLGIDGRVAVPYPSTVAELQRMFPTPPSLEQHPAFSPITTYRDTPSQETPAPSAGHEHPLNTHTNNQLNDYRSEMDESMTSPKAEDIRPQMGCSMFAPLRTLPSQCLPPLKIPEQCYYRPSWSMLPKMEPYCLPSQAPFVRDGYVNVPSIGALQDQDYAQMSTGTASVGTAGGVLPSPATPRFSVPTPRTPRTPRGVGTASGQGSIKQDGTELSSPISTPSTGLPLSSVEPLASGPVLPEAHSLYVILLLSDSVLDVFKDRSFDSCCICACNMNVKGADVGIYIPDSTREDQYRCMCGFSAIANRRLAHGAGLFLEDELDIFGRGSEAGRAAERRLALGRRDTPTGGKRAQEQTPMEVLELIQEQCSQPILSVASLHSPAACSCRSRQRALLQSWVADRLWADGSDACVECYNALVQGLQYVDNAAGGKVEQALVRSSALHSWPHTNVLDISMLSSQDVVRMLLSLQPFLQDAIQKKRTGRTWENIQHVQGPLTWQQFHKMAGRGSYGSEESPEPLPIPTLLLGYDRDFLALSPLALPFWEKLLLEPYGGQRDVAFLVLCPDNDILLTGARTFFQELSAVYESCRLGKHHPLARMSRDGIVPVGAMESEKLEENGREVDEWMTGPWAGQYREDHLSKLKLYAQTCKQKLAPQLSALSLDSSLLLPPKPQPSSAPAPSTQLNPGSGAPEGETSATAAAAGVPGSGNTPTSTSTSTGQASTEGADTLQSVPNTTPIQQSHPTESAESLAERERIGIPTAAQSADSHAYPPAIVLYLVDPFLCSGSGVGSGEEEEAEEVESRSMWLLALLRCYTDMLSVLPENIQPALVLQVVPCQYLLQPASGESPLYLQHLRSLAFSAHSQCRRRLPTQTHIKSLTGFGPAATIDSLFKSVENPSSMQVYSPPFVLAPLRTKQPEVGEEATTRYNVLFVGYCLSHDQRWILVSCTDQQGELLETCIINIDVPNRSRRPKFSPRKIGLQKLWEWCIGIIQMTAIPWRIVIGRLGRLGHGELKDWSLLLGEHSLHSISRQLREACRMCGISATDSPSILSACLVSMEPQGSFVVMPDAVTMGSVFGRSTALNLQTSQLNTPQDASCTHILVFPTSSTTQVAPSSYPTEDNPDDIFGLPFTDDLEKDIEHDMMLITGNLHASPNTSPVPSPGSPSGLGVGSHFPHTRSQGERLLSREAPEELKQQPLALGYYVSTAQAEGLPHWFWASCPQAQNQCPLFLKASLHHHISIAQTDELVSSKTSQRNPHPLDSKTTSDVLRFVLEQYNALSWLTCSPATQDRRSCLPVHLVILTQMYNAILNIL
Length2099
PositionMiddle
OrganismIctalurus punctatus (Channel catfish) (Silurus punctatus)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Actinopterygii> Neopterygii> Teleostei> Ostariophysi> Siluriformes> Ictaluridae> Ictalurus.
Aromaticity0.07
Grand average of hydropathy-0.375
Instability index56.88
Isoelectric point5.49
Molecular weight229836.96
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP15706
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      56.71|      17|      23|    1303|    1319|       1
---------------------------------------------------------------------------
 1303- 1319 (34.14/22.91)	SPEPLPI.PTLLL...GYDRD
 1324- 1344 (22.57/11.82)	SPLALPFwEKLLLepyGGQRD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      64.58|      18|      22|    1473|    1493|       2
---------------------------------------------------------------------------
 1473- 1490 (31.72/11.90)	PGSGAPEGETSATAAAAG
 1492- 1509 (32.86/20.92)	PGSGNTPTSTSTSTGQAS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      68.72|      22|      22|     436|     457|       3
---------------------------------------------------------------------------
  436-  457 (39.16/15.80)	TNPSSSSSSSSLSSSLP.........PPSTP
  574-  604 (29.56/10.01)	TAPEMSDTALYTASLVPreanggwwkSYRTP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      60.28|      17|      22|     293|     311|       4
---------------------------------------------------------------------------
  293-  311 (26.35/19.60)	LPVEqpPPAQGAQSGTRDS
  316-  332 (33.93/18.22)	IPLT..PPTSPEQPCSGDS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      62.90|      20|      23|    1510|    1529|       6
---------------------------------------------------------------------------
 1510- 1529 (35.71/21.34)	TEGADTLQ.....SVPNTTPIQQSH
 1531- 1555 (27.20/14.28)	TESAESLAereriGIPTAAQSADSH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      63.92|      10|      23|     815|     824|       8
---------------------------------------------------------------------------
  540-  549 (21.92/ 9.14)	PLPPTLSPHP
  815-  824 (21.68/ 8.94)	PTPPSLEQHP
  841-  850 (20.31/ 7.80)	PAPSAGHEHP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      69.33|      23|      28|    1072|    1099|       9
---------------------------------------------------------------------------
 1072- 1099 (38.75/33.73)	GIYIpdstrEDQYRCMC.GFSA..IANRRLA
 1103- 1128 (30.58/15.64)	GLFL.....EDELDIFGrGSEAgrAAERRLA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      62.04|      19|      28|     959|     977|      10
---------------------------------------------------------------------------
  959-  977 (37.64/18.01)	VGTA.........GGVLPSP.ATPRFSVP
  988- 1016 (24.40/ 8.92)	VGTAsgqgsikqdGTELSSPiSTPSTGLP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      86.78|      20|      22|    1189|    1208|      11
---------------------------------------------------------------------------
 1167- 1184 (25.58/13.28)	..LHSPAACSCRSRQRALLQ
 1189- 1208 (38.42/24.22)	DRLWADGSDACVECYNALVQ
 1214- 1227 (22.78/10.90)	DN.AAGGK...VE..QALVR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      90.57|      23|     806|     868|     892|      12
---------------------------------------------------------------------------
  868-  892 (37.61/22.90)	ESMTSPKAEDI.RPQMGcsMFAPLRT
 1657- 1673 (21.66/ 6.79)	.....PTQTHI.KSLTG...FGPAAT
 1679- 1701 (31.29/12.86)	KSVENPSSMQVySPPF...VLAPLRT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      51.07|      13|      22|     485|     497|      15
---------------------------------------------------------------------------
  485-  497 (25.58/12.45)	SVDQQPCPEQDAP
  510-  522 (25.50/12.39)	SLDTLPGCKYPKP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      39.18|      11|      22|    1609|    1619|      17
---------------------------------------------------------------------------
 1609- 1619 (19.28/ 9.67)	PENIQPALVLQ
 1629- 1639 (19.91/10.26)	PASGESPLYLQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      71.29|      20|      24|      65|      84|      18
---------------------------------------------------------------------------
   65-   84 (36.36/24.98)	QANLLCVWRRKLKPDAKELW
   91-  110 (34.92/23.66)	EPNLSDIIHHELEVVEEGLW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      71.73|      23|      57|     550|     572|      19
---------------------------------------------------------------------------
  550-  572 (42.44/23.16)	RVQDPEVM..EAPMD...VSQCLEGTSL
  605-  632 (29.29/13.85)	RVDKAELKppELPYDmveIKAEGEGTAL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP15706 with Med13 domain of Kingdom Metazoa
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