<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP15703

Description mediator of RNA polymerase II transcription subunit 23 isoform X3
SequenceMAVPMETQLQSIFEDVVKTEVIEEAFAGMFMDTPEDERTKLISCLGAFRQYWGSLPQESHEQCVQWIVRFIHSQHSPKRISFLYDCLAMAVETNLLPPKMVCQALIGSETLEWERAQLWSLTFKLIRKIIGGVDYKGVRDLLKAVLDKMQTIPNLVSSAVVQQLLPAREVVEYILDRNACLLPAYFAVTEIRKLYPEGQLSHWLLGSLISDFVDSFRPTARINSICGRCSLLPVVNNSGAICNSWKLDPATLRFPLRGMLPYDKDLFEPQTGLLRYVLEQPYSRDMVCNMLGLNKQTLNIAQHKQRCPVLEEQLVDLVVYAMERSETEEQFDDGGTSQLLWQHLSSQLIFFVLFQFASFPHMVLSLHQKLAGRGLIKGRDHLMWVLLQFISGSIQKNALADFLPVMKLFDLLYPEKECIPVPDINKPQSTHAFAMTCIWIHLNRKAQNDNSKLQIPIPHSLKLHHEFLQQSLRNKSLPMTDYKIALLCNAYSTNSECFTLPMGVLVETIYGNGTVRIPLPGTNCTASCSITPLPMNLLDSLTVHAKMSLIHSIATRVIKLAHAKSSIALAPALVETYSRLLVYMEIESLGIKGFISQLLPNVFKSHAWGILHTLLEMFSYRMHHIQPHYRVQLLSHLHSLAAVPQTNQNQLHLCVESTALRLITALGSSEVQPQFTRFLSDPKTVLSAESEELNRALILTLARATHITDFFTGSDSIQGTWCKDILQTIMNFTPHNWASHTLSCFPAPLQAFFKQNNVPQESRFNLKKNVEEEYRKWKSMTNENDIITHFSMQGSPPLFLCLLWKMLLETDHINQIGFRVLERIGARALVAHVRTFADFLVYEFSTSAGGQQLNKCIEILNDMVWKYNIVTLDRLILCLAMRSHEGNEAQVCYFIIQLLLLKPNDFRNRVSDFVKENAPEHWLQSDWHTKHMSYHKKYPEKLYFEGLAEQVNPPMQLQPQYLPIYFGNVCLRFLPVFDIVIHRFLELLPVSKSLETLLDHLGGLYKFHDRPVTYLYNTLHYYERHLRDRTNLKRKLVHAIMSSLKDNRTPGWCLSETYLKFGMNPREDNVWVPDDTYYCKLIGRLVDTMAGKSPGPFPNCDWRFNEFPNPAAHALHVTCVELMALAVPGGDVGNALLNVVLRSQPLVPRENVTAWMNAIGLIITALPEPYWIVLHDRIVSVIGSPALTSDAEWVGYPFQLLDFTACHQSYSEMYCSYVLALAHAVWHHSSIGQLSLIPKFLSEVLKPLVKTEYQLLYIYHLVGPFLQRFQQERTRCMLEIGVAFYEMLQAVDHHSNHLAYMDPICDFLYHIKYMFTGDSVKDQVEKIICTLRPAMKLRLRFITHTSKMEPAAAVATATSASQPTTVSSPAPQTGTGPSSIPLSVPQ
Length1386
PositionTail
OrganismIctalurus punctatus (Channel catfish) (Silurus punctatus)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Actinopterygii> Neopterygii> Teleostei> Ostariophysi> Siluriformes> Ictaluridae> Ictalurus.
Aromaticity0.10
Grand average of hydropathy-0.019
Instability index46.52
Isoelectric point7.01
Molecular weight158118.85
Publications









Function






Annotated function


GO - Cellular Component
nucleus	GO:0005634	IEA:UniProtKB-SubCell

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP15703
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      69.80|      19|      65|    1223|    1241|       1
---------------------------------------------------------------------------
 1223- 1241 (36.98/21.72)	HAVWHHSS.IGQLSLIPKFL
 1289- 1308 (32.82/18.45)	QAVDHHSNhLAYMDPICDFL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     105.19|      34|      66|      90|     155|       2
---------------------------------------------------------------------------
   90-  129 (52.58/65.57)	AVETNLLPPKMVCQALIGSEtlewerAQLWSLTFKL..IRKI
  159-  194 (52.61/16.82)	AVVQQLLPAREVVEYILDRN......ACLLPAYFAVteIRKL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      45.92|      14|      43|     335|     362|       3
---------------------------------------------------------------------------
  335-  358 (18.58/20.40)	GTSQLLWqhlssqliffVLFQFAS
  378-  391 (27.34/11.73)	GRDHLMW..........VLLQFIS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      71.08|      19|      76|     784|     802|       4
---------------------------------------------------------------------------
  784-  802 (36.14/21.99)	NDIITHFSMQGSPPLFLCL
  861-  879 (34.93/21.01)	NDMVWKYNIVTLDRLILCL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     108.25|      32|      81|     455|     535|       5
---------------------------------------------------------------------------
  228-  260 (54.41/14.69)	RCSLLPVVNNSGA.ICNSWKLDPATLRFPLrGML
  473-  505 (53.84/71.61)	RNKSLPMTDYKIAlLCNAYSTNSECFTLPM.GVL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      56.60|      16|      16|    1005|    1020|       6
---------------------------------------------------------------------------
 1005- 1020 (31.60/17.43)	YKFHDRPVTYLYNTL.H
 1022- 1038 (25.00/12.45)	YERHLRDRTNLKRKLvH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      51.19|      13|      17|     261|     275|       7
---------------------------------------------------------------------------
  261-  273 (25.15/18.77)	PYDKDLFEPQTGL
  281-  293 (26.04/11.94)	PYSRDMVCNMLGL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      39.15|      11|     300|     594|     604|      11
---------------------------------------------------------------------------
  594-  604 (21.86/12.78)	FISQLL...PNVFK
  894-  907 (17.29/ 8.51)	FIIQLLllkPNDFR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     137.13|      40|     602|     706|     747|      12
---------------------------------------------------------------------------
  706-  747 (70.12/49.96)	HITDFFTGsDSIQGTWCKDI..LQTIMNFTpHNWASHTLSCFPA
 1310- 1351 (67.01/38.90)	HIKYMFTG.DSVKDQVEKIIctLRPAMKLR.LRFITHTSKMEPA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      83.16|      26|     462|     644|     682|      13
---------------------------------------------------------------------------
  611-  637 (44.04/32.89)	LHTLLEMFSYRM......HHIQPHYrVQLLSHL
  651-  682 (39.12/31.02)	LHLCVESTALRLitalgsSEVQPQF.TRFLSDP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      96.46|      27|      90|    1073|    1102|      15
---------------------------------------------------------------------------
 1073- 1102 (45.84/47.48)	PdDTYYCKLIGRLVDTMAgkSPGPFPNCDW
 1167- 1193 (50.62/37.98)	P.EPYWIVLHDRIVSVIG..SPALTSDAEW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      57.96|      17|     498|     316|     332|      21
---------------------------------------------------------------------------
  314-  330 (28.46/18.24)	LVDLVVYAMERSETEEQ
  836-  852 (29.50/19.17)	FADFLVYEFSTSAGGQQ
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP15703 with Med23 domain of Kingdom Metazoa
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