Description | Mediator of RNA polymerase II transcription subunit 4 |
Sequence | MASLASKSFEFSPNRSLWLSTTRGSLPSFLSSQIQSMPPPPLESNTSSTNEILSLFTSLQTQLFEAVAELQEILDLQDAKQRIARDIKSKDSALLNFANKLREAEKVLDILVDDYSDYRRPKRAKSKSLEDDCVSNTTIASQLELSDILSYAHRISYSTFAPPDFGAGQAPLRGALPPAPQEEQMRASQLYAFTDLDVGLPKNVENKEKIIEAIIEPPPPPKPSETNQLPNFSAIQSLLPPNITVPFGWKSGMPVVLPTDLPPPPPGWKLGDPLPPLESLPLSRLGEQQWQPVAPQGLHKPPETIQVRHVQIDILDQGDDSSDYSSNEGSSDDED |
Length | 335 |
Position | Middle |
Organism | Manihot esculenta (Cassava) (Jatropha manihot) |
Kingdom | Viridiplantae |
Lineage | Eukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> eudicotyledons> Gunneridae> Pentapetalae> rosids> fabids> Malpighiales> Euphorbiaceae> Crotonoideae> Manihoteae> Manihot. |
Aromaticity | 0.06 |
Grand average of hydropathy | -0.489 |
Instability index | 69.33 |
Isoelectric point | 4.63 |
Molecular weight | 36888.00 |
Publications |
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364141 |
GO - Cellular Component | core mediator complex GO:0070847 IBA:GO_Central mediator complex GO:0016592 IEA:InterPro |
GO - Biological Function | transcription coregulator activity GO:0003712 IBA:GO_Central |
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IBA:GO_Central |
Binary Interactions |
Repeats | >MDP15647 --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 3| 91.13| 24| 177| 38| 63| 1 --------------------------------------------------------------------------- 20- 42 (26.56/11.07) ...STTRGSLPSFLSSQIQ.smpPPPL 44- 63 (24.69/ 6.59) SNTSSTNEILSLFTSLQTQL....... 221- 243 (39.87/12.98) PKPSETNQ.LPNFSAIQSLL...PPNI --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 3| 98.29| 19| 36| 247| 265| 2 --------------------------------------------------------------------------- 247- 265 (41.96/21.79) FG...WKSGMPVVLP..TDLPPPP 266- 284 (29.31/13.07) PG...WKLGDP..LPplESLPLSR 285- 302 (27.02/11.50) LGeqqWQ...PVA.P..QGLHKPP --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 41.30| 16| 35| 73| 90| 3 --------------------------------------------------------------------------- 75- 95 (12.26/15.24) DLQDAKqRIARdIKSKdsaLL 114- 129 (29.04/18.87) DYSDYR.RPKR.AKSK...SL --------------------------------------------------------------------------- |
MoRF Sequence | Start | Stop |
1) ETIQVRHVQIDIL 2) KIIEAI | 303 209 | 315 214 |
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