<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP15647

Description Mediator of RNA polymerase II transcription subunit 4
SequenceMASLASKSFEFSPNRSLWLSTTRGSLPSFLSSQIQSMPPPPLESNTSSTNEILSLFTSLQTQLFEAVAELQEILDLQDAKQRIARDIKSKDSALLNFANKLREAEKVLDILVDDYSDYRRPKRAKSKSLEDDCVSNTTIASQLELSDILSYAHRISYSTFAPPDFGAGQAPLRGALPPAPQEEQMRASQLYAFTDLDVGLPKNVENKEKIIEAIIEPPPPPKPSETNQLPNFSAIQSLLPPNITVPFGWKSGMPVVLPTDLPPPPPGWKLGDPLPPLESLPLSRLGEQQWQPVAPQGLHKPPETIQVRHVQIDILDQGDDSSDYSSNEGSSDDED
Length335
PositionMiddle
OrganismManihot esculenta (Cassava) (Jatropha manihot)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> eudicotyledons> Gunneridae> Pentapetalae> rosids> fabids> Malpighiales> Euphorbiaceae> Crotonoideae> Manihoteae> Manihot.
Aromaticity0.06
Grand average of hydropathy-0.489
Instability index69.33
Isoelectric point4.63
Molecular weight36888.00
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
core mediator complex	GO:0070847	IBA:GO_Central
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IBA:GO_Central

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IBA:GO_Central









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP15647
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      91.13|      24|     177|      38|      63|       1
---------------------------------------------------------------------------
   20-   42 (26.56/11.07)	...STTRGSLPSFLSSQIQ.smpPPPL
   44-   63 (24.69/ 6.59)	SNTSSTNEILSLFTSLQTQL.......
  221-  243 (39.87/12.98)	PKPSETNQ.LPNFSAIQSLL...PPNI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      98.29|      19|      36|     247|     265|       2
---------------------------------------------------------------------------
  247-  265 (41.96/21.79)	FG...WKSGMPVVLP..TDLPPPP
  266-  284 (29.31/13.07)	PG...WKLGDP..LPplESLPLSR
  285-  302 (27.02/11.50)	LGeqqWQ...PVA.P..QGLHKPP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      41.30|      16|      35|      73|      90|       3
---------------------------------------------------------------------------
   75-   95 (12.26/15.24)	DLQDAKqRIARdIKSKdsaLL
  114-  129 (29.04/18.87)	DYSDYR.RPKR.AKSK...SL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP15647 with Med4 domain of Kingdom Viridiplantae
Unable to open file!