<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP15633

Description Mediator of RNA polymerase II transcription subunit 6
SequenceMAPILEFPPNPNFRFSYGGREDSYATDKFIKFVDDSLHNLRRCHLAKPIKIVCGSAACLFKLIKMATPPGVNFEGNPPAAPQPPGTDMTGMCFRDQLWLNTYPLDRNLIFDYFALSPFYDWTCNNEQLRLQSIHPLDLSQLTKMTGTEYMLSEVMEPNLFVFRKQKRDSPEKVTPMLTYYILDGSIYQAPQLCNVFAARIGRALYYISKAFTTAASKLEKIGYVDEGEGVPCEPKTNKDLIDFKEVKRIDHILASLQRKLPPAPPPTPFPDGYAPPATTEAEKSAETQQGAESQPPVDPIIDQGPAKRMKF
Length311
PositionHead
OrganismManihot esculenta (Cassava) (Jatropha manihot)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> eudicotyledons> Gunneridae> Pentapetalae> rosids> fabids> Malpighiales> Euphorbiaceae> Crotonoideae> Manihoteae> Manihot.
Aromaticity0.11
Grand average of hydropathy-0.392
Instability index57.07
Isoelectric point6.45
Molecular weight35022.88
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU364143

GO - Cellular Component
core mediator complex	GO:0070847	IBA:GO_Central
mediator complex	GO:0016592	IBA:GO_Central

GO - Biological Function
transcription coactivator activity	GO:0003713	IBA:GO_Central

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IBA:GO_Central









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP15633
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      50.58|      11|     181|      77|      87|       2
---------------------------------------------------------------------------
   77-   87 (24.38/ 8.73)	PPAAPQPPGTD
  261-  271 (26.20/ 9.86)	PPAPPPTPFPD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      53.22|      14|      29|      92|     105|       4
---------------------------------------------------------------------------
   92-  105 (29.85/21.36)	CFRDQLWLNT.YPLD
  123-  137 (23.37/15.21)	CNNEQLRLQSiHPLD
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP15633 with Med6 domain of Kingdom Viridiplantae


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) KLPPAPPPTPFPDGYAPPATTEAEKSAETQQGAESQPPVDPIIDQGPAKRM
259
309










Molecular Recognition Features






MoRF SequenceStartStop




1) AEKSAET
2) ILASLQRK
3) PVDPIIDQGPAKRMKF
281
252
296
287
259
311