<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP15603

Description Mediator of RNA polymerase II transcription subunit 15
SequenceMSDPNRMQEDYPAASFRMKIVNRLEEVMRNSQTQMPKTSSEMEDYVFNKARTREEYLDLVARLLLTVSDQNKDKKMNLNMGPNMGQPGGPMRPQVSVSGQDQDPMNALQSLAGPSMGRQQHGEMFGGSYEQTGDQFVNQFDSLGGMMQGMGGPMVNQQQMANQQSQQQRMMDMRQQQQQQMQQQQQRMMMNRMPQLQRQDAFLVTSPQGMAGVQGQPIPSSTGMSYQGPGGPIRNMGPIGLSGHYMQGRDMGLQGMPVQSPAQNSPLTMLPSPHGMMPSPGMRPQMGVASPSTVLHTPGTAVSDPSPGPPSTSLEEQEYIRKLEKLSCYIEPLRKFVLESEKKTDEDSKKNHKKMKSLLDILSNPKKRVPINVLEKCQQVLEKLLNNLLQTTSFNVPITQGHMCQPLLDAVAHFSTATMLNHSLHRTFGPALEAYKGASLIKYAAFNILCYDQSLYKA
Length458
PositionTail
OrganismBiomphalaria glabrata (Bloodfluke planorb) (Freshwater snail)
KingdomMetazoa
LineageEukaryota> Metazoa> Spiralia> Lophotrochozoa> Mollusca> Gastropoda> Heterobranchia> Euthyneura> Panpulmonata> Hygrophila> Lymnaeoidea> Planorbidae> Biomphalaria.
Aromaticity0.05
Grand average of hydropathy-0.673
Instability index63.70
Isoelectric point8.86
Molecular weight51068.02
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU364148

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP15603
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      65.06|      17|      17|     164|     180|       1
---------------------------------------------------------------------------
  164-  180 (35.17/16.15)	QSQQQRMMD..MRQQQQQQ
  182-  200 (29.89/12.63)	QQQQQRMMMnrMPQLQRQD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      82.62|      25|      29|     251|     279|       2
---------------------------------------------------------------------------
  254-  279 (46.88/21.05)	QgMPVQSPAQ..NSPLTMLPSPHGMMPS
  285-  311 (35.74/ 8.32)	Q.MGVASPSTvlHTPGTAVSDPSPGPPS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      87.55|      25|      29|      62|      86|       3
---------------------------------------------------------------------------
   62-   86 (45.58/25.01)	RLLLTVSDQNKDKKMNLN..MGPNMGQ
   92-  118 (41.97/22.45)	RPQVSVSGQDQDPMNALQslAGPSMGR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      80.27|      24|      24|     358|     381|       4
---------------------------------------------------------------------------
  358-  381 (41.11/29.26)	LL.DILSNPKKRVPINVLEKCQQVL
  384-  408 (39.16/27.52)	LLnNLLQTTSFNVPITQGHMCQPLL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      52.95|      15|      16|     125|     139|       5
---------------------------------------------------------------------------
  133-  150 (24.86/ 8.81)	GDQFVNQfdsLGGMMQGM
  215-  229 (28.09/10.79)	GQPIPSS...TGMSYQGP
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP15603 with Med15 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) QNKDKKMNLNMGPNMGQPGGPMRPQVSVSGQDQDPMNALQSLAGPSMGRQQHGEMFGGSYEQTGDQFVNQFDSLGGMMQGMGGPMVNQQQMANQQSQQQRMMDMRQQQQQQMQQQQQRMMMNRMPQLQRQDAFLVTSPQGMAGVQGQPIPSSTGMSYQGPGGPIRNMGPIGLSGHYMQGRDMGLQGMPVQSPAQNSPLTMLPSPHGMMPSPGMRPQMGVASPSTVLHTPGTAVSDPSPGPPSTSLEEQ
70
317










Molecular Recognition Features






MoRF SequenceStartStop




NANANA