<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP15599

Description Uncharacterized protein
SequenceMQQKMTPQGGMMMGVAPPPLSSGNTISLSSLIDYALQRTHHELIILSELLPRKSDMERKIEIFQFASRTRQLFVRLLALVKWANSASKVDKCMDICNFLEQQSMYFVETADSLHKMAKETLASARLPSFSLPCAIDVLTTGTYPRLPTCIRERIIPPDPITPQEKTQTLQRLNEVIQYRLVSNELPKQMRRLKIDQGRVKFFVEQEFEVTLTLMGDSPTIPWRLLDVSFLVEDHETGHGKSLVHSMQVHYIHELVQSRLLHVDHPLHDLYKVLHSFCQSLQLEVLHSQAQRLMLDRLRDSISIVEYSLSKSLSISYWRDQQKKKDNLEHFPIHKLSVHVNEEDEGKPLQISHTPPMSTAESRKVGLAIKSDHLSIEKLLMHTIEVRTHSKLKELARELQKLIDGKCEVRDMPVALHVSVLNPCMTSEVLRISIDVQTGAYMASVPSCDRSAVQGIEDSLNGEHRGLEKLLMKLKVQLVLQRCEKCVQLMTAHCRPTLPLINATEHTLNKLAATRLYVRVPKQQGYYVVVEVKESEHRKVEVNYYMLETTQCTADGLEDDIGDEAPVKAFMKAGQLTPIDTYSMAHSQFCKIFDGIPLTMDSLTRKRKIFLGEDIDEPDAKKMKGSPYFVSELAYLLARCEEKMPFVFLGEELSKQGISHDGGTLDATGTCLSLGILYFPEVLGLPEEVNDGLRKQLLQCKFRIQNRQSRLWILEFIFNRSPLPSIHIKESGQSQRVCYALDMNGDNIQKTVSDLIDEWTSIAYLFGAVHRFADSYNMGRTSLASIVEVQSYNYKKLTLAYGPNMCSLLSVKWKPATRRFELTLGTRLPSASANPHIPLLLQLTEEFNLHCSLSQLSQTLHDTWTPMMSISKLPSAAVLGASTNTRQHIQNFTIIPQSSSHVRLVCRSSNCIDVHFRGNKTVAVKDGACSLFDTSKPIEGLQPTAGLKAFLSMFVDEGVTMGLGRRQSATADDNPPSPLDPSEIFSSQQSTGSPLPRPTQPQARQESFRFHSPMTPPSNPHTPASPGNARLLAGVNPSPSTTLMGTPSPGTLLTANSPGNPQLHVPSPGPFAPVPSPQSMVGLHMQSPVTSFMSGIVDGGSPFPVSSLAMPSPGAVRGGWVGSPSVQDPSPMSQHAVHSPGHPALHSPQMHKDGDHKPGVVNMQPRMLPQRAWAAAIPTILSHKGFDNLLTPTPDPQQGSVQHSPASPLERFFACIIMKKHFSRLVNTESMMQFIPSTEPGVLCFKVDTLQYRLSLNTTTSQSLHMKISPVPEHQDKWMPEELQILEKFFDLKVFCPPYRLNALTAVGRIISAPCRILKDCIQIMKLELIPDRSMKWTVQWCLTIPPSLHFISPVGVPAFVVKTKMIFMLQLTRIGLTVGPSEQSFVVPLLYEMQTNKLTRVEQKIPQMNNTPSLQAVSTMLNRFADHYQQQNHSNECAILPAVKELLTNLVVPV
Length1454
PositionTail
OrganismBiomphalaria glabrata (Bloodfluke planorb) (Freshwater snail)
KingdomMetazoa
LineageEukaryota> Metazoa> Spiralia> Lophotrochozoa> Mollusca> Gastropoda> Heterobranchia> Euthyneura> Panpulmonata> Hygrophila> Lymnaeoidea> Planorbidae> Biomphalaria.
Aromaticity0.06
Grand average of hydropathy-0.218
Instability index53.32
Isoelectric point8.33
Molecular weight162598.25
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU365082

GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP15599
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     501.29|      87|      88|     985|    1072|       1
---------------------------------------------------------------------------
  824-  903 (84.42/35.73)	......GTRLPsasaNPHIPLLLQltEEFN..............L.......HCSLSQLSQT.....lHDTWTP.....MMS.ISKLPSAAVLGASTNTRQHIQNFTIIPQ....SS.....SHVRL
  904-  982 (102.91/45.12)	VCRSSNCIDVH...fRGNKTVAVK..DGAC..............S.......LFDTSKPIEG......LQPTAGLKAFLSMF.VDEGVT...MGL...GRRQSATADDNP....PSP.....LDPSE
  985- 1072 (155.09/74.64)	SSQQSTGSPLP....RPTQPQARQ..ESFR..............F.......HSPMTPPSNP......HTPASPGNARLLAG.VNPSPSTTLMGTPSPGTLLTANSPGNPQLHvPSP.....GPFAP
 1075- 1157 (109.15/48.29)	SPQSMVGLHMQ....SPV..........TS..............FmsgivdgGSPF.PVSSL......AMP.SPGAVR..GG.WVGSPS...VQDPSPMSQHAVHSPGHPALH..SPqmhkdGDHKP
 1163- 1240 (49.72/17.89)	....................QPRM..LPQRawaaaiptilshkgF.......DNLLTPTPDPqqgsvqHSPASPLE.RFFACiIMKKHFSRLVNTESMMQFIPSTEPG...................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     207.70|      70|      88|     365|     440|       2
---------------------------------------------------------------------------
  365-  440 (96.45/74.50)	GL..AIKSDHLSIEKLLMhtiEVRTHSKLKELARELQkLIDGKCEvRDMP.VALHVSVLNPcMTSEVLRISIDVQTGAY
  454-  526 (111.25/64.43)	GIedSLNGEHRGLEKLLM...KLKVQLVLQRCEKCVQ.LMTAHCR.PTLPlINATEHTLNK.LAATRLYVRVPKQQGYY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      43.96|      12|      82|    1258|    1270|       3
---------------------------------------------------------------------------
 1258- 1270 (19.14/13.02)	TTSQSLHMkISPV
 1343- 1354 (24.82/12.78)	TIPPSLHF.ISPV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     187.24|      61|      87|     205|     266|       4
---------------------------------------------------------------------------
  205-  266 (101.72/72.22)	QEFEVTLTLMGDSPTI.PWRL...LDVSFLVEDHETGHG..KSLVHSMQVHyIHELVQSRLLHVDH..PL
  288-  356 (85.52/55.14)	QAQRLMLDRLRDSISIvEYSLsksLSISYWRDQQKKKDNleHFPIHKLSVH.VNEEDEGKPLQISHtpPM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      40.20|      11|      15|     773|     783|       6
---------------------------------------------------------------------------
  773-  783 (21.07/14.17)	DSYNMGRTSLA
  789-  799 (19.13/12.19)	QSYNYKKLTLA
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP15599 with Med14 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) GSPFPVSSLAMPSPGAVRGGWVGSPSVQDPSPMSQHAVHSPGHPALHSPQMHKDGDHKPGVVNMQP
2) MGLGRRQSATADDNPPSPLDPSEIFSSQQSTGSPLPRPTQPQARQESFRFHSPMTPPSNPHTPASPGNARLLAGVNPSPSTTLMGTPSPGTLLTANSPGNPQLHVPSPGPFAPVPSPQSMVGLHMQSPVTSFMSGIVD
1099
960
1164
1097










Molecular Recognition Features






MoRF SequenceStartStop




NANANA