<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP15595

Description Uncharacterized protein
SequenceMATAFPSQEHTPIKKPRLGPPDVYPQDPKQKEDELTQQNVKHGFQLGTVVTDECASAKDIEITLEKCSTFYNSVLKKKNELNTLQDSKNKKFQLPVKEHFWPAACSKPSTEAWFKDLAGSKPLASLSRKVPTFNKKEEIFSTLCEYAVPNVRAAWFIKMTAAHNMGTQDSRNRRKLTVDQFMDWTQAISKYLKDQLQKIQDFYHGTSGATATPFLLAPSPATSQVDLDLAMKNWNYCTRFANHLYEEGLLDRHDFLNWLIELPDKMKQTDDVVLKLILVQMNIYSSDMCKSVILVRRLANYCGRKISHLVAEMDHMLGRTDPQMSANGTPLTPAQAINTTIQMCNPLINAMAEFKECQSHRFIVLQLCALAQIITIKCPTAMVWNSLGDYKSNSYLVGSPLDLYPCATSSLPMPPGQSNTYIRQQVKNAEQQIIARSHSAEVHWSSDKCQQSAVGYIMSKVLKVLDVLDQHNFDIVDSIYNMDSLYTKIFSITQSKETGEAPIGDEPIINLLVDWAVSVQRVGDHRCIVVALLLERRQNEIRSEKFGEVESGDDKDGVHSETLTSTPVFQSLLMSFLDTRAPVLEEHPTDEAKQAFKNLISLFNELIVHDVFSHDAYMHMLISRGDLGLAPAYTAPLADQDDLFSTKSPPESIKHEVTLGDDEIKVDMDIHTMEENFGSLFGSMKEESKPSPEPPASVKSIKSEKEQPLGSVGDFSTTPAAPAPPKGPSRHMVYATHFPIPQDDCSSHEINQRMIVLYGVGKARDEARHMFKKISKEIVKLFSKRNCIDVTSGDLGKVKKKKEKEAKEAETNATPSTLNTTVTSPNFDNLQQKFSKLSYFDQHQVTAQCTSAVLDQIKSFTAGNSSYLPLGDNISFLFDLMQSALNINGLLEFIIRILKDLVEVEKELHQKESFLMMTYTTDVCLNIVAVLRRYHSYLLSPQGLSSELFIGLTDILKVVNVCNPIYCSTAERCVLTYLYDIYSTCSPLQMRHSEIFNPAYTKMKATLFAQITPSSTNAKWDQNEMTDIIKSARLPDEPHKLHKSLADCATTRYSFVCNVLLHVVSTSAENLRTINDLAVLCAELTAHCNSLSPEWLGVLKALCCSSQQDLGFIDVLTTIDVSDLSIHDSLAVFTAMLIARHCFSLQDFVYHVALPSLMAVCCPEEGDAEAESGARLSCHLLLRLFKPSYLIAPQCSISQKNPPPIRNSCDRHLLEAAHLFIGVGPMLAVLKAMLKLADESNDESTSKGSSGNSKDKTGMFLDYMLRNLETDGISAEMEAMLSASSGGQSGKDGLGSGSLSEFAKCALTEICRQDWVREKFLRNPEKLFTSDLLNDPILSYRQAQQLLQLICYPTGVPNQVEGCEPENKHVVQRVLQTLDQWTLRVSWLELQLLFERAQSVAETNSLLELVSRGTIDLFDQLTENKNTSESSSVSITSENKSNIENTIWLVAPLIAKLPSTIQGRVLKLAAAVLEQSINEYSSAKNKQEKEKEKNIRSKTLLGHQPFLSLVLSCLKGQDEQREFLLRSLLNQMEMLISNFKDYTENKGLEEGKIRQSIQECIHLRLSLVGGIFDVIQRNNASTSDWALILVQLVSHDMIDCQSNSELFLTVVDMLTVLIHGTLLSEGQEKGDENRKPYFNLIKKLRKELGDKNNPTIDQVRQLFPLPKKQCEVITVEPYGAVLDNKGNRVQGFDAIGKKPGLQVAQKVVFNPWEIIEGHKNMPPIPWSYFGAVRLEKKTLKYEEQKRLDLYHSHCLRKPLSYYLEPPNLPPEDLEPIPEKHDEKPREHIEHSLDLKKTVNNKKKKRPAKPAPPSNFPNIVSHDITLVFWYLS
Length1831
PositionKinase
OrganismBiomphalaria glabrata (Bloodfluke planorb) (Freshwater snail)
KingdomMetazoa
LineageEukaryota> Metazoa> Spiralia> Lophotrochozoa> Mollusca> Gastropoda> Heterobranchia> Euthyneura> Panpulmonata> Hygrophila> Lymnaeoidea> Planorbidae> Biomphalaria.
Aromaticity0.07
Grand average of hydropathy-0.306
Instability index44.14
Isoelectric point6.08
Molecular weight205776.38
Publications









Function






Annotated function


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP15595
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     118.40|      36|      37|    1074|    1110|       1
---------------------------------------------------------------------------
 1074- 1109 (68.63/46.94)	I..............NDLAVLCAELTA.HCNSLSPEWLGV....LKALCCSSQQD
 1113- 1167 (49.77/27.57)	IdvlttidvsdlsihDSLAVFTAMLIArHCFSLQDFVYHValpsLMAVCCPEEGD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      99.95|      23|      80|      85|     107|       3
---------------------------------------------------------------------------
   85-  107 (42.90/31.53)	QDSKNKKFQLPVKEHF.WPAACSK
  124-  144 (24.79/14.43)	ASLSRKVPTFNKKEEI.FSTLC..
  168-  190 (32.25/21.47)	QDSRNRR.KLTVDQFMdWTQAISK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     111.85|      28|     710|      11|      38|       4
---------------------------------------------------------------------------
   11-   38 (52.78/34.07)	TP.IKKPRLGPPD..VY......PQDPKQKEDELTQQ
  689-  710 (24.37/10.85)	.....KPSPEPPA..SV......KSIKSEKEQPLG..
  718-  753 (34.70/19.29)	TPaAPAPPKGPSRhmVYathfpiPQDDCSSH.EINQR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      56.06|      17|     711|     802|     818|       6
---------------------------------------------------------------------------
  802-  818 (27.94/18.76)	KEKEAKEAETNATPSTL
 1484- 1500 (28.13/18.95)	KNKQEKEKEKNIRSKTL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      77.75|      23|     711|     269|     293|       7
---------------------------------------------------------------------------
  269-  293 (35.25/26.02)	TDdvVLKLILVQMNIYSSDMCKSVI
  953-  975 (42.50/25.21)	TD..ILKVVNVCNPIYCSTAERCVL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     509.70|     171|     206|    1294|    1478|       9
---------------------------------------------------------------------------
 1294- 1478 (248.77/236.26)	LGSgslSEFAKCALTEICRQDWVREKFLR...NPEKLFTS...DLLNDPILSYRQAQQLLQLiCYPTGVpNQVEGCEpenkHVVQRVLQTLDQWTLRVSWLELQLLFErAQSVAE....TNSLLELVSRGTI..DLFDQLTENKNTSESSSVSITSE..NKSNieNTIWLVAPLIaKLPSTiQGRVLKLA..AAVLEQSIN
 1501- 1687 (260.93/196.03)	LGH...QPFLSLVLSCLKGQDEQREFLLRsllNQMEMLISnfkDYTENKGLEEGKIRQSIQE.CIHLRL.SLVGGIF....DVIQRNNASTSDWALILVQLVSHDMID.CQSNSElfltVVDMLTVLIHGTLlsEGQEKGDENRKPYFNLIKKLRKElgDKNN..PTIDQVRQLF.PLPKK.QCEVITVEpyGAVLDNKGN
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP15595 with Med12 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) MATAFPSQEHTPIKKPRLGPPDVYPQDPKQKEDELTQQNVKH
2) PEDLEPIPEKHDEKPREHIEHSLDLKKTVNNKKKKRPAKPAPPSN
3) SLFGSMKEESKPSPEPPASVKSIKSEKEQPLGSVGDFSTTPAAPAPPKGPSRHMVYATHFPIPQDDC
1
1770
679
42
1814
745










Molecular Recognition Features






MoRF SequenceStartStop




1) HIEHSLDLKKTVNNKKKKRPAK
2) HTPIKKPRLG
1787
10
1808
19