<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP15594

Description Uncharacterized protein
SequenceMATAFPSQEHTPIKKPRLGPPDVYPQDPKQKEDELTQQNVKHGFQLGTVVTDECASAKDIEITLEKCSTFYNSVLKKKNELNTLQDSKNKKFQLPVKEHFWPAACSKPSTEAWFKDLAGSKPLASLSRKVPTFNKKEEIFSTLCEYAVPNVRAAWFIKMTAAHNMGTQDSRNRRKLTVDQFMDWTQAISKYLKDQLQKIQDFYHGTSGATATPFLLAPSPATSQVDLDLAMKNWNYCTRFANHLYEEGLLDRHDFLNWLIELPDKMKQTDDVVLKLILVQMNIYSSDMCKSVILVRRLANYCGRKISHLVAEMDHMLGRTDPQMSANGTPLTPAQAINTTIQMCNPLINAMAEFKECQSHRFIVLQLCALAQIITIKCPTAMVWNSLGDYKSNSYLVGSPLDLYPCATSSLPMPPGQSNTYIRQQVKNAEQQIIARSHSAEVHWSSDKCQQSAVGYIMSKVLKVLDVLDQHNFDIVDSIYNMDSLYTKIFSITQSKETGEAPIGDEPIINLLVDWAVSVQRVGDHRCIVVALLLERRQNEIRSEKFGEVESGDDKDGVHSETLTSTPVFQSLLMSFLDTRAPVLEEHPTDEAKQAFKNLISLFNELIVHDVFSHDAYMHMLISRGDLGLAPAYTAPLADQDDLFSTKSPPESIKHEVTLGDDEIKVDMDIHTMEENFGSLFGSMKEESKPSPEPPAIDLNLGSLNASVKSIKSEKEQPLGSVGDFSTTPAAPAPPKGPSRHMVYATHFPIPQDDCSSHEINQRMIVLYGVGKARDEARHMFKKISKEIVKLFSKRNCIDVTSGDLGKVKKKKEKEAKEAETNATPSTLNTTVTSPNFDNLQQKFSKLSYFDQHQVTAQCTSAVLDQIKSFTAGNSSYLPLGDNISFLFDLMQSALNINGLLEFIIRILKDLVEVEKELHQKESFLMMTYTTDVCLNIVAVLRRYHSYLLSPQGLSSELFIGLTDILKVVNVCNPIYCSTAERCVLTYLYDIYSTCSPLQMRHSEIFNPAYTKMKATLFAQITPSSTNAKWDQNEMTDIIKSARLPDEPHKLHKSLADCATTRYSFVCNVLLHVVSTSAENLRTINDLAVLCAELTAHCNSLSPEWLGVLKALCCSSQQDLGFIDVLTTIDVSDLSIHDSLAVFTAMLIARHCFSLQDFVYHVALPSLMAVCCPEGDAEAESGARLSCHLLLRLFKPSYLIAPQCSISQKNPPPIRNSCDRHLLEAAHLFIGVGPMLAVLKAMLKLADESNDESTSKGSSGNSKDKTGMFLDYMLRNLETDGISAEMEAMLSASSGGQSGKDGLGSGSLSEFAKCALTEICRQDWVREKFLRNPEKLFTSDLLNDPILSYRQAQQLLQLICYPTGVPNQVEGCEPENKHVVQRVLQTLDQWTLRVSWLELQLLFERAQSVAETNSLLELVSRGTIDLFDQLTENKNTSESSSVSITSENKSNIENTIWLVAPLIAKLPSTIQGRVLKLAAAVLEQSINEYSSAKNKQEKEKEKNIRSKTLLGHQPFLSLVLSCLKGQDEQREFLLRSLLNQMEMLISNFKDYTENKGLEEGKIRQSIQECIHLRLSLVGGIFDVIQRNNASTSDWALILVQLVSHDMIDCQSNSELFLTVVDMLTVLIHGTLLSEGQEKGDENRKPYFNLIKKLRKELGDKNNPTIDQVRQLFPLPKKQCEVITVEPYGAVLDNKGNRVQGFDAIGKKPGLQVAQKVVFNPWEIIEGHKNMPPIPWSYFGAVRLEKKTLKYEEQKRLDLYHSHCLRKPLSYYLEPPNLPPEDLEPIPEKHDEKPREHIEHSLDLKKTVNNKKKKRPAKPAPPSNFPNIVSHDITLVFWYLS
Length1840
PositionKinase
OrganismBiomphalaria glabrata (Bloodfluke planorb) (Freshwater snail)
KingdomMetazoa
LineageEukaryota> Metazoa> Spiralia> Lophotrochozoa> Mollusca> Gastropoda> Heterobranchia> Euthyneura> Panpulmonata> Hygrophila> Lymnaeoidea> Planorbidae> Biomphalaria.
Aromaticity0.07
Grand average of hydropathy-0.300
Instability index43.80
Isoelectric point6.08
Molecular weight206658.40
Publications









Function






Annotated function


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP15594
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     364.12|      98|     105|     630|     732|       1
---------------------------------------------------------------------------
  548-  628 (74.37/40.40)	..........................EVESGDDKDGVHSETLTSTPVFQSLLMSF.LDtrapvlEEHPTDEAKQAFKNLISLfnELIVHDVFSHDA..ymHMLISRGDLG......
  635-  732 (165.49/109.10)	APL..ADQDDLFSTKSP.PES..IKHEVTLGDDEIKVDMDIHTMEENFGSLFGSM.KE......ESKPSPEPPAIDLNLGSL..NASVKSIKSEKE....QPLGSVGDFSTTPAAP
  733-  835 (124.25/70.99)	APPkgPSRHMVYATHFPiPQDdcSSHEI...NQRMIVLYGVGKARDEARHMFKKIsKE......IVKLFSKRNCIDVTSGDL...GKVKK.KKEKEakeaETNATPSTLNTTVTSP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     267.87|     101|     198|     853|     974|       2
---------------------------------------------------------------------------
  863-  913 (41.06/61.21)	................................................................VLDQIKSFTAgNSSYLPLgdniSFLFDLMQSALNINGLLEFIIRILKDLVE
  920-  974 (70.32/39.13)	QKESFLMMTYTTDVC.LNIVAVLRRYHSYLLSPQGLSSELFIGLTDILKVVNVCNP...........................................................
 1118- 1173 (68.49/37.71)	QDLGFIDVLTTIDVSdLSIHDSLAVFTAMLIARHCFSLQDFVYHVALPSLMAVCCP...........................................................
 1356- 1428 (88.01/54.48)	.....................................LQLICYPTGVPNQVEGCEPenkhvvqrVLQTLDQWTL.RVSWLEL....QLLFERAQSVAETNSLLELVSRGTIDLFD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      66.11|      18|      41|      97|     114|       3
---------------------------------------------------------------------------
   97-  114 (37.07/26.30)	KEHFWPAACSKPSTE...AWF
  136-  156 (29.04/18.70)	KEEIFSTLCEYAVPNvraAWF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     156.82|      48|     709|     989|    1055|       4
---------------------------------------------------------------------------
  989- 1047 (78.88/96.88)	YDIYSTCSPLQMRHSEIFNPAYTKM..KATLFAQITPsstnakwdqneMTDIIKSA.RLPDE
 1198- 1248 (77.94/51.27)	YLIAPQCSISQKNPPPIRNSCDRHLleAAHLFIGVGP...........MLAVLKAMlKLADE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      74.55|      20|      64|     235|     254|       6
---------------------------------------------------------------------------
  235-  254 (40.11/23.73)	NYCTRFANHLYEE..GLLDRHD
  300-  321 (34.45/19.42)	NYCGRKISHLVAEmdHMLGRTD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     188.23|      59|     510|    1050|    1112|       8
---------------------------------------------------------------------------
 1050- 1112 (92.83/83.57)	KLHKSLADCATTRYSFVCNVlLHVVStsaENLRTINDLAVLCAELTAH....CNSLSPEWLGVLKAL
 1561- 1623 (95.40/72.18)	KIRQSIQECIHLRLSLVGGI.FDVIQ...RNNASTSDWALILVQLVSHdmidCQSNSELFLTVVDML
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      89.53|      28|      58|     358|     386|       9
---------------------------------------------------------------------------
  358-  386 (48.26/40.08)	QSHRFIVLQL.CALAQIITiKCPTAMV.WNS
  417-  446 (41.27/28.60)	QSNTYIRQQVkNAEQQIIA.RSHSAEVhWSS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     132.89|      38|    1553|     190|     228|      10
---------------------------------------------------------------------------
  190-  228 (62.64/42.00)	KYLKDQLQKIQDFYHGTSGATATPFLLAPsPATSQVDLD
 1746- 1783 (70.26/43.15)	KTLKYEEQKRLDLYHSHCLRKPLSYYLEP.PNLPPEDLE
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP15594 with Med12 domain of Kingdom Metazoa
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