<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP15583

Description Mediator of RNA polymerase II transcription subunit 16
SequenceMELVYSIDFKTYSKENEFSFDEKICCSLSCRNIVAFSRARVSEANGDKVEMCYEVCVVDLDKPWQEYEVTTYPSPVKYMRWDPAGTALLVVNAAGRFSLWTMKNNLINVWEESGHVDMDKEEILVLAWLHNGSQVLFNPEARDVITYPDKFSRAKMIPSVTQFGKKPVDGWIAITSTAMVHVGLIPDKGSALVTAKASIGQTNSHIIQADVAFMPDGQILIATSDGYLTSSVHCYVAAVTLKNHVCSIRTSPSASFFLKKQSVPDGTQEEPRLTRLSFLSRENSEILLACWGTSSFSCVEAWHLIDQTIPLNRMFQNAAVTEYAYKTKRWIHKSSFTQRSALTDIARPKLPISRSFNMESTNFLSYFACTYRDGTIKIVHRQSYQVIHTAFMEQLINFKSLVPTDNVIAEPFEKRARLSVPHLVSVVQTNTGCGLVGLDESRLYLFRIFNSRDGSLQLMPPFVILLLEYTMFVGLDVWDVLLAVRQGMVEGIVEKLNTNFQKQSVAFQELLQQRLLRLKMALYSCLSSGNQRAADCRAMITLHAITTVLKSCLRPKSVTAQDKSPSEKLTNLCSVSMEKDIDQIIKNIDVEEFILDSFKKAGSVKPSCEASLQALQPFIQWITDFILHLLAAVSMYPNPTYPGSTLIKNPQVLCTLRELLIIIRIWGRFNPVCLPVFMTTVSMDALSYLFHLVTKALITIREGAALESDQTFVDECCNLPSEILLPNYKKTFGEEMNCYLAFSQPFPINYQFGEEPDFLFNPRYSSRIYPLDLCLDADQKYDCVRQIQLGVNPKEPLRECVRCHSLSLRRKVSATKSSLLKAWELRFVKSCLCGGHWKLKTSQQNTLGQK
Length850
PositionTail
OrganismBiomphalaria glabrata (Bloodfluke planorb) (Freshwater snail)
KingdomMetazoa
LineageEukaryota> Metazoa> Spiralia> Lophotrochozoa> Mollusca> Gastropoda> Heterobranchia> Euthyneura> Panpulmonata> Hygrophila> Lymnaeoidea> Planorbidae> Biomphalaria.
Aromaticity0.10
Grand average of hydropathy-0.045
Instability index43.12
Isoelectric point8.13
Molecular weight96191.22
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP15583
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     309.46|      77|     155|     387|     463|       1
---------------------------------------------------------------------------
  387-  463 (126.75/72.54)	IH..TAFMEQLINFKSL.....VPTDNVIAEPFEKRARLSVPHLVSVVQT....NTGC.....GLVGLDESRLYLFR....IFNS.....RDG.SLQLMPPFV
  542-  619 (99.05/55.22)	LHaiTTVLKSCLRPKSV.....TAQDKSPSEKLTNLCSVSMEKDIDQIIK....N..........IDVEEFILDSFKkagsVKPS.....CEA.SLQALQPFI
  622-  713 (83.66/45.59)	I...TDFILHLLAAVSMypnptYPGSTLIKNP...QVLCTLRELLIIIRIwgrfNPVClpvfmTTVSMD.ALSYLFH....LVTKalitiREGaALESDQTFV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     257.96|      54|     156|     119|     172|       2
---------------------------------------------------------------------------
   68-  101 (30.41/15.62)	........................EVTTYPS...........................PVKYMRWDPAGTALLVV...NAAGrfslWT
  119-  172 (93.58/63.75)	DKEEILVLAWLHNGSQVLFNPEARDVITYPD...........................KFSRAKMIPSVTQFGKK...PVDG....WI
  187-  266 (54.14/33.71)	DKGSALVTAKASIGQTNSHIIQA.DVAFMPDgqiliatsdgyltssvhcyvaavtlknHVCSIRTSPSASFFLKKqsvP.DG......
  282-  331 (79.83/53.28)	ENSEILLACW...GTSSFSCVEAWHLIDQTI...........................PLNRMFQNAAVTEYAYK....TKR....WI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      61.14|      17|      19|     717|     735|       3
---------------------------------------------------------------------------
  717-  735 (29.27/25.57)	CNLPSEILLP.NYKktFGEE
  738-  755 (31.88/20.70)	CYLAFSQPFPiNYQ..FGEE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      48.54|      13|      14|     782|     794|       8
---------------------------------------------------------------------------
  782-  794 (24.16/16.47)	DCVRQIQLGVNPK
  799-  811 (24.38/16.69)	ECVRCHSLSLRRK
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP15583 with Med16 domain of Kingdom Metazoa
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