<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP15547

Description Mediator of RNA polymerase II transcription subunit 17
SequenceMRPYLSLYLLSSITAADCSTTNCKSFHGSRDWPSHSVWASLNGTLGGRLLAPLPPGAVCHAEQPSYNASACPERKKEWSRYEWHAEDPLSVMWDQFTHYSCLPDANAPCTARGYPTYVVNASTAEHVKTGIDFARNHNIRLVVKNSGHDFIGRSVAPGALSIWAHNLNTIKFNPEEFKLDGSSRVIKTNSMTIGGGVQMYDAYKAADQHGQTITGGGGKSVAFGGYVSGGGHSFVAPYFGLAADNILQMEVVTPAGDIMTVNEDQYPEIFWALRGGGGSTFGVITSLTIKSYPKARVSYTSYKIVADPQAPFLWDMITYVISQLPYLMDSGFAGKNFVNHSMPNPDPSSGLPSKVAGVSGQNLLLNASEPNIAAKIFKPINDTLQSRWPGKVLLHLETQHYPTSLAWFEKNYDASTGGYSRYLVSRLLDKQSLTGNETALRDALKAANEPNGLLAFFTVAGKGVQNAKPRGGDAVHPAWRQAYVHSVATAEFPPFNKTAEREAIAILDRSFQPLRDLTPNSGAYMNEALPFEKDWQHTFWGSNYERLLAIKKNVDPTDVFCYTASCPGMTIGDSIGDSKHHHQASANPIPRRQPTHEALHCPAPATATMSAAEATFLSLRPVPIADKEPKNLAEFISRVNAQPGGFRDVTESALREAIETNGDASVEDVVMVDAVEEEDAAAPSKDAASARLEVLKGVDIAGNTAMLILDSLSLLLSKQSPTSASLTLSQQLRDMVGIGTLSVDRLDEPTAREERVKDGEQVATGWTLMEINKTRDAAVSAAALLDKEVAIESRYWDDVMAVKKAGWSMCRVPNERHTLGVRFGFSETSTEFKNNGLAPMRRGEDGSVELDVGRLGGVSECLVVSYVRNDRVVGRSRPHRRQRNATSLESRVLEARNTIFSQELWHELIKEARTLAAYDVRLQGSQLRCRVDDETALTMELLELSSCPAPDDSLPYNDMAEAVSLGLHMLLSYAHRHNELMRTRPMPPHMSRSRPTNQTYALLRPIIARLVSDASIEACTRLVGSLSRALTKAGLASSFTLRPSSSPTTDPSSSSPSSHASPSQTLIRNMLQPRDLAIDFSILPDISLSIRLRTFLFPVTSSHFNVSLPPDSPLRPSSAPYQDGYPDVRALADYLDTTVSRCLTRHFLSRLPPDDANGNTRRWTETIVGTSIRDPDSDRWSLRFSTVRNDADPIPSAALILASSVVGPDGDPPRRRSWKWSSGENPEDEPRSMADVVAEVARMTPS
Length1246
PositionHead
OrganismOphiocordyceps camponoti-rufipedis
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Hypocreomycetidae> Hypocreales> Ophiocordycipitaceae> Ophiocordyceps.
Aromaticity0.07
Grand average of hydropathy-0.339
Instability index49.32
Isoelectric point6.22
Molecular weight136332.93
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
FAD binding	GO:0071949	IEA:InterPro
oxidoreductase activity	GO:0016491	IEA:InterPro
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP15547
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      94.26|      27|      34|    1167|    1200|       1
---------------------------------------------------------------------------
 1167- 1198 (45.10/39.72)	IVGtsirdPDSD...RWSLRFSTVRNDADPIPSAA
 1205- 1234 (49.16/25.43)	VVG.....PDGDpprRRSWKWSSGENPEDEPRSMA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      53.12|      15|      34|     194|     208|       2
---------------------------------------------------------------------------
  194-  208 (28.83/17.70)	GGGVQMYDAY..KAADQ
  229-  245 (24.30/13.77)	GGGHSFVAPYfgLAADN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     111.02|      35|     108|     862|     896|       4
---------------------------------------------------------------------------
  862-  896 (59.05/30.71)	LVVSYVRNDRVVGRSRPHR....RQR..NATSLESRVLEAR
  969- 1009 (51.98/26.25)	MLLSYAHRHNELMRTRPMPphmsRSRptNQTYALLRPIIAR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      98.66|      28|      40|    1084|    1111|       5
---------------------------------------------------------------------------
 1084- 1111 (51.35/34.25)	PDI.SLSIRLRTFLFPVTSSHFNVSLPPD
 1126- 1154 (47.31/30.92)	PDVrALADYLDTTVSRCLTRHFLSRLPPD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     102.46|      35|      40|     733|     771|       8
---------------------------------------------------------------------------
  731-  769 (55.47/54.92)	QL...RD.MVGIGTLsvdrLDEPTAREERVKDGEQVA..TGWTLM
  770-  810 (46.99/35.12)	EInktRDaAVSAAAL....LDKEVAIESRYWDDVMAVkkAGWSMC
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      90.13|      23|      64|     461|     483|      10
---------------------------------------------------------------------------
  461-  483 (43.61/31.35)	GKGVQNAKPRGGDAVHPAWRQAY
  522-  544 (46.52/34.01)	GAYMNEALPFEKDWQHTFWGSNY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      31.08|       8|      57|     215|     224|      11
---------------------------------------------------------------------------
  215-  224 (13.10/ 9.82)	GGGGKSvaFG
  275-  282 (17.98/ 7.55)	GGGGST..FG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     161.95|      43|     701|     327|     370|      13
---------------------------------------------------------------------------
  327-  370 (74.45/46.60)	LMDSGFAGKNFVN...HSMP........NPDPSSGLPSKVAGVSgQNLLLNASEP
  383-  428 (44.55/22.02)	TLQSRWPGKVLLHletQHYPtslawfekNYDASTGGYSRYL.VS..RLL......
 1045- 1073 (42.96/20.95)	.................SSP........TTDPSSSSPSSHASPS.QTLIRNMLQP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     122.25|      34|     219|      65|     103|      14
---------------------------------------------------------------------------
   65-  103 (63.29/40.47)	SYnasacPERKKEWSRYEWHAEDPLSVMWDQFTH.YSCLP
  291-  325 (58.96/28.59)	SY.....PKARVSYTSYKIVADPQAPFLWDMITYvISQLP
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP15547 with Med17 domain of Kingdom Fungi
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