Description | Mediator of RNA polymerase II transcription subunit 4 |
Sequence | MDKRIDSRFERLEKALSSLVDSVTKYHPSVAQAEELQAADAQLSLGLEEVQVHQNNHLLIQQLRRTSSALDAQIRDTLTSLASTRKDIVSTQITKFSSEPNHPISYDELLAYARRISKTTLPPAATILTASPSPETQTPAAGGATSDPQPQLSSAVTPSARTPSRTESPVANGTLAQPTNPDQPAQPNSASQNTSLPEGMSQYLNPLSGQVFFPWPLEDKIRSGALASYQMLVEQGIDPRGYDPVTEEERKRKEEDERKAKEEREKAEREDRERQLREEREKLRVERERQREKEQEAWRKASIATGMPGAAMPARAVSGTGDKKQFQFTNLDDLDDDDDDEG |
Length | 342 |
Position | Middle |
Organism | Ophiocordyceps camponoti-rufipedis |
Kingdom | Fungi |
Lineage | Eukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Hypocreomycetidae> Hypocreales> Ophiocordycipitaceae> Ophiocordyceps. |
Aromaticity | 0.04 |
Grand average of hydropathy | -0.944 |
Instability index | 53.35 |
Isoelectric point | 5.03 |
Molecular weight | 38062.53 |
Publications |
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364141 |
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro |
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro |
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro |
Binary Interactions |
Repeats | >MDP15546 --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 44.17| 14| 15| 257| 270| 1 --------------------------------------------------------------------------- 257- 270 (24.27/16.73) ERKAKEEREK..AERE 273- 288 (19.90/12.35) ERQLREEREKlrVERE --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 84.18| 26| 29| 124| 151| 2 --------------------------------------------------------------------------- 124- 150 (42.24/24.98) AATILTASPSpETQTPAAGGATSDP....QP 155- 184 (41.94/16.67) AVTPSARTPS.RTESPVANGTLAQPtnpdQP --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 66.32| 21| 29| 62| 82| 4 --------------------------------------------------------------------------- 62- 82 (33.32/20.29) QLRRTSSALDAQI.RDTLTSLA 92- 113 (33.01/20.04) QITKFSSEPNHPIsYDELLAYA --------------------------------------------------------------------------- |
MoRF Sequence | Start | Stop |
1) AWRKASIAT 2) DKKQFQFTNLDDLDDDD 3) MPARA 4) YDELLAYA | 297 322 312 106 | 305 338 316 113 |
© 2021 Shailesh Lab
Designed by Dr. Shailesh Lab & Dr. Jitendra K. Thakur Lab