<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP15543

Description Uncharacterized protein
SequenceMTSRPPMGVPPRQPPRAPAPNLAVQHHQRSLSQQYLAPSSSPSSSPSVRRDPHVDAPGEPPESLSSGSQARPHASTPRRGSSKLRLELSTNDWDSALANTTDSPQILTPSRVAPVSVPVPDATSAVDKVSPAQSGSQLDDNPPIPMPKRRPQPIEKPISAPRPSTTAVAPTKKDARPKPYTVEVPSDAPRFVSIHKHDIPNRDPFSKGLHNGHADFFPWSGQHHEDEWSSEAIQKGTWDRGAQNETSSARMAVLPALKQKSGLNALSTIFMGVMNQRRFRGQILSPSTFKPPPRVTLTDTKREVWLKDLANPTISLRRLSRTIPHGIRGRTLLDQCLNKNVPTERAVWLAKCVGANEIRAFKRKGAGGAFVMGGESKWVRDWTVFVEQFVEAVVSAFGEPDWKTRVTYAIRLATNLYSEHLLDRDHYLDWITSNLENSSQAKMPMWILIAQITWADLVRSRKYGRRLVYTLLAQLNIIHNDPDRDILIQLSSQLTGLLKTLLRNNPESFVAPGLWPRHRDALKAFLAQDDGVSQDAWQRVNGRNARLLVASTASPPAGRQHLIKLFDSTIQGHYDRELAAKCLAVTDDRAELVKTLVEWATSVHRPGLAKIYVAVSLIKSWAATNATSVIVDLLDDVPPTDRLRKKAIFHLVSELVRGGLFSVPKYIKWLIGRGGLHDAAEIDPDDGPCSSRLLVELPIHCLSESQRSQRTNLLRRAGQYSTADEAKDMANALRCVDGSLGLSQHLGDADGASNKCLSLPKLLRRVSHSSKAVQSSIGAHLRDVLTPELLAKVEPVAALSMFSSARLVLETAQDFGCLSQVLKSHAAASDVDVLAACADTINSLLDVFLAMGTADGLFGSLSGRLKSLNREQAAGARPLLVALTSLARRLPHRSGIAQQLQRELAQSERSSAIDACSPVSDSMALNGESEVSEQIDKLLASGNTVDPPTMNRLFRNIIPKLEAGWVKADGGRRLLASLLARLRIFDAQHFDKLMADWVSHVGTLGERPRLATLFPMLISLGCLSMPMVLQSANSVADPGSASDASAVYLQELLQLVVMKPPRAAACLDTVEAYRFEVQQKAARLEHPGALLSLIRKAVSEYAAVGTRHRPLDEAGCEDGLVETMRYLVVADSSAVAKALDVGTLATGAVELVKRIVGKLLAPDGQGGCQESLDRLLSLSNELTMPFCQLKLDVDLSGEGDDKALEGFARAMDRAIEARSIAWTRMLPCLSQDITRSLSTQAHARFLGLMPSPKSAKEEEEKEEKDDDDDDGHVVDLAENLLGVLEAITPPKSAQLTTALAEKLCDLWEIVASPQQHQKKREVVLDRWLPALLRFVVLHSACAPEATGTGATGATTTTNTNSSTANTAPTSATTTAATAPTTATTTATSPQHDDVRARIILILCGLLLELDRPSLSEHVLDVATLLIDTLPDETRIQCSKTVLFLPGSASQPHASSSSSDARLYYLFSLQPPTWAENLKLAHKERASIAYSAAARGMSTLYGIGPASSERLSPYVLRRWEVLSEPTPNVGENDTSLSLGLFEAIKMQ
Length1546
PositionKinase
OrganismOphiocordyceps camponoti-rufipedis
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Hypocreomycetidae> Hypocreales> Ophiocordycipitaceae> Ophiocordyceps.
Aromaticity0.05
Grand average of hydropathy-0.234
Instability index45.10
Isoelectric point8.11
Molecular weight168219.75
Publications









Function






Annotated function

Component of the SRB8-11 complex. The SRB8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The SRB8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.


Component of the srb8-11 complex. The srb8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The srb8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.



GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP15543
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      81.86|      17|      18|      37|      53|       1
---------------------------------------------------------------------------
    3-   16 (23.94/ 8.87)	..SRPP...MGVPP.RQPPR
   37-   53 (32.84/15.05)	APSSSP...SSSPSVRRDPH
   56-   73 (25.07/ 9.66)	APGEPPeslSSGSQAR..PH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      66.60|      19|      22|    1276|    1294|       2
---------------------------------------------------------------------------
 1276- 1294 (31.42/18.24)	LAENLLGVLEAITPPKSAQ
 1299- 1317 (35.18/21.33)	LAEKLCDLWEIVASPQQHQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      57.88|      19|      22|     465|     486|       3
---------------------------------------------------------------------------
  465-  483 (31.97/22.74)	RRLVYTLLAQLN.IIHNDPD
  488-  507 (25.91/ 9.43)	IQLSSQLTGLLKtLLRNNPE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      39.70|      12|      18|    1168|    1181|       4
---------------------------------------------------------------------------
 1168- 1181 (17.32/12.48)	CQESLDrlLSLSNE
 1187- 1198 (22.37/10.15)	CQLKLD..VDLSGE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      63.38|      18|      25|     145|     168|       5
---------------------------------------------------------------------------
  145-  162 (37.41/30.59)	PMPKR.RPQP..IEKPISAPR
  170-  190 (25.97/ 7.35)	PTKKDaRPKPytVEVPSDAPR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     180.41|      67|     489|     550|     675|       6
---------------------------------------------------------------------------
  551-  583 (41.39/45.08)	...........................................STASPPAGRQHLIKLFDSTI...QGHYDRELAA.KCL
  635-  675 (35.42/39.66)	DDVPPTDRLRKKAIFHLVSELVRGGLFSvpkyikwLIGRGG.......................................
  685-  757 (103.61/38.23)	DDGPCSSRLLVELPIHCLSESQRSQRTN.......LLRRAGqySTADEAKDMANALRCVDGSLglsQHLGDADGASnKCL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      52.39|      16|      18|     319|     336|       8
---------------------------------------------------------------------------
  319-  336 (23.87/23.59)	LSRTIPHgiRGRTLLDQC
  337-  352 (28.52/19.59)	LNKNVPT..ERAVWLAKC
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      42.46|      15|      18|     865|     879|       9
---------------------------------------------------------------------------
  865-  879 (25.65/13.65)	LKSLNRE..QAAG.ARPL
  883-  900 (16.81/ 6.43)	LTSLARRlpHRSGiAQQL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     373.80|      99|     175|     759|     862|      10
---------------------------------------------------------------------------
  759-  858 (153.71/88.17)	LPKLLRRVSHSSK...AVQSSIGAHL.RDVLtPELLAK.VE.PVAALSMFSS..ARLVLETAQDFGCLSQVLKSHAAA.SD..VDVL..AACADT..INSL..LDV.FLAMGTADGLF
  935- 1036 (123.20/65.44)	IDKLL....ASGN...TVDPPTMNRLfRNII.PKLEAGwVK.ADGGRRLLASllARLRIFDAQHFDKLMADWVSHVGTlGE..RPRL..ATLFPM..LISLgcLSM.PMVLQSANSVA
 1049- 1147 (96.88/53.28)	LQELLQLVVMKPPraaACLDTVEAYR.FEV..QQKAAR.LEhPGALLSLIRK..A..VSEYAA.VGTRHRPLD.EAGC.EDglVETMryLVVADSsaVAKA..LDVgTLATG......
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      75.15|      25|     175|     105|     134|      11
---------------------------------------------------------------------------
   76-  103 (37.58/18.97)	TPRRGSSklrLELSTNDWDSALAN..TTDS
  108-  134 (37.57/20.47)	TPSRVAP...VSVPVPDATSAVDKvsPAQS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      58.90|      18|      18|     251|     268|      13
---------------------------------------------------------------------------
  251-  268 (27.96/18.02)	MAVLPALKQKSGLNALST
  271-  288 (30.94/20.80)	MGVMNQRRFRGQILSPST
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      42.72|      12|      21|     510|     521|      15
---------------------------------------------------------------------------
  510-  521 (24.54/12.37)	VAPGLWPR..HRDA
  532-  545 (18.18/ 7.27)	VSQDAWQRvnGRNA
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP15543 with Med12 domain of Kingdom Fungi
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