Description | Mediator of RNA polymerase II transcription subunit 19 |
Sequence | MSVHPQTPQSPCRFSPATSSDSAVMGLSSLATLPTPAHSVNGANAQPDDSPHKRKRALDDMAGPRKKMHLEDDRMGIEDLHLDVGPKYLLCQTVYPESLPRTSSDLYQMFGLTALAAEVAREKPNGEKNALRKTYKGHIKRLGVAGHFDVHKKSEDAPSEFMAMIEVPELEWNVHQVKGRDIAHGLSDATLSNLARAVTLSRGSLPKSVWDSSVLGDLALTANDAPKSLSAKPTAPSTPLASTPNAIGRSKPQLPVAAGPDVARPRRNNKKRSYGDSSFEGYGEGYPDDDAGVDTGYSTGEGEGGQKRRKKSSGSSPTYSSMRQQSYGPGMVGA |
Length | 334 |
Position | Head |
Organism | Ophiocordyceps camponoti-rufipedis |
Kingdom | Fungi |
Lineage | Eukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Hypocreomycetidae> Hypocreales> Ophiocordycipitaceae> Ophiocordyceps. |
Aromaticity | 0.05 |
Grand average of hydropathy | -0.684 |
Instability index | 53.53 |
Isoelectric point | 8.86 |
Molecular weight | 35735.58 |
Publications |
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364151 |
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro |
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro |
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro |
Binary Interactions |
Repeats | >MDP15542 --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 3| 184.50| 48| 200| 17| 66| 2 --------------------------------------------------------------------------- 17- 66 (81.42/53.74) ATSSDSAVM.GLSSLATLP.TPAHSVngANAQPDDSPHKRKRALDDMAGPRK 101- 133 (49.17/25.83) RTSSDLYQMfGLTALAAEV.AR............EKPNGEKNAL......RK 229- 267 (53.91/29.04) ...........LSAKPTAPsTPLAST..PNAIGRSKPQLPVAAGPDVARPRR --------------------------------------------------------------------------- |
MoRF Sequence | Start | Stop |
1) HKRKRAL 2) PTYSSMRQQSYGPGMVG 3) QKRRKKSS 4) YGEGYP | 52 317 306 282 | 58 333 313 287 |
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Designed by Dr. Shailesh Lab & Dr. Jitendra K. Thakur Lab