<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP15539

Description Mediator of RNA polymerase II transcription subunit 16
SequenceMLDNAMPVHLQDVDDLFGDDVALSLPLRPQRKQLLARLDELRSRGCCQSVAWSRSGTIASLTPDGQTLQLRFLRCDPENGSWELSDPTICEAIKGTPAIPLVHLEWSSTTSPDLAVVDAIGRVAIASFPITLNHPFITRRWDADAVDDSHAVVGSFWLPVVPSAQQKQPYNIIHGPARKHGNTYQYETSFLHAGGTNHPHSSKSALLCVTMGGMLKMYWSQNNGRIEETLREIESVNSTDELVTHAALASDKSMCSLSLWSLPGCFWRLMLLRLEVRWAGLGVAPDKSALPHNARLSPVLEETHLAYTSWLHGGPGPNEMNPDPSATALSYLHMLPSILDNQGKNTVPPVIVTIRSRAAAEGSFQTAQSILDRWEVVEDRQTLPSAFEQLGNRRNSISLDLPNVTVLRKLEPILINKIVIGLQTIQFGKMLLLTMSDGTVEYRDRYSFEEMFTAEDLTRVMNLRQVGWTLADIGPCQQVAFSPTQCSMVLLGDDGKLRWCKLQYSMGDIGDSMQDVHYVATIAGLAVTAASAIWYQSNYDDMLAVVQPLASKKKFTQEWVSELIRILKIQVDYSEEMHHDTLMRNSPLQSCLSIMNSLGFRGVARKRSFQSKFAWVNLNVRNVVVLITLASNTPVTVRDKMSPLDEHEVVDALTGCVQWSLDLLSWLADSLFGLLMDRDFTQRLAPQRFAELASYLQDRNEVSLHLILCSSSRSFLSALCRRVSHLEQLSNKAIEFYGRQAGGPDQGNGGRLMVPRLQQAYLRLQQVTTSSQINVSEFERLLNTLASDIRQAYQTILPNRIKSGPNPPQGKQLEAAIKTAQVQFEVGALLTPSPPMAFLPVLKKLFGHDLAAFRAQTDPSSIFFSDFELIGVLDDDISLAARKASGVELDLFRKVELRRDTPGQVVRRCARCTAVMEDVYVGKAGFSFILSQQRRCSCAGHWALPADAKTTR
Length952
PositionTail
OrganismOphiocordyceps camponoti-rufipedis
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Hypocreomycetidae> Hypocreales> Ophiocordycipitaceae> Ophiocordyceps.
Aromaticity0.07
Grand average of hydropathy-0.133
Instability index47.67
Isoelectric point6.44
Molecular weight105915.07
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP15539
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     459.09|     116|     119|     157|     273|       1
---------------------------------------------------------------------------
   25-  139 (122.80/70.92)	...LPLRP..QRKQLLARL.DELRSRGccQSVAWSRSgtiasltpdgqtlqlrFLRCD.PEN..GSWELSDPTICEAIKGtpaipLVHLEWS....ST.....................TSPDLAVVDAIGRVAIA.......SFPITLNHPFITR
  157-  273 (204.07/126.69)	W..LPVVPSaQQKQPYNIIHGPARKHG..NTYQYETS................FLHAG.GTN..HPHSSKSALLCVTMGG.....MLKMYWS....QNNGRIEETLREIESVNSTDELVTHAALASDKSMCSLSLW.......SLPGCFWRLMLLR
  278-  390 (132.22/76.95)	WagLGVAPD.KSALPHNARLSPVLE.E..THLAY.TS................WLHGGpGPNemNPDPSATALS...........YLHMLPSildnQGKNTVPPVIVTIRSRAAAEGSFQTA.....QSI..LDRWevvedrqTLPSAFEQL....
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     147.43|      48|      55|     400|     451|       2
---------------------------------------------------------------------------
  400-  451 (74.13/64.96)	DLPNVTVLRKLEPILINkivIG.LQTIQFG....KMLLLTmSDGTVEY.RDRYSFEEM
  456-  509 (73.30/51.01)	DLTRVMNLRQVGWTLAD...IGpCQQVAFSptqcSMVLLG.DDGKLRWcKLQYSMGDI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     140.28|      46|      55|     642|     688|       3
---------------------------------------------------------------------------
  642-  688 (77.41/55.51)	SPL.DEHEVVDALTGCVQwSLDLLSWLADSLFGL..LMDR..DFTQRLA..PQR
  694-  746 (62.87/38.74)	SYLqDRNEVSLHLILCSS.SRSFLSALCRRVSHLeqLSNKaiEFYGRQAggPDQ
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP15539 with Med16 domain of Kingdom Fungi
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