<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP15537

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMPITAQSVSFRLFTLALVLLQRLPIERHGRSWPAAGLERDTMALASSNNGDVNNGNTNNSSNNNNNGDVNASANANANLNLNLNLNLNGARSRMNDLPDEIIHITQGFVPLSLLLTRLAQTSHNALQDKMAELAKMPLPATAVNGNATSALDDTSTDNLRKKAALASFAQDLHGKWLKALVITEWSRKSDMVSKLIDLKFHIDQQRILYDACLDNVVNVKRDLTFARMPSPDLKTALQILSTGTAPWMPDLNYIEPPRLTPREQLKWISDLNTLLSLRLNLDDYDKIPPHFKDYDIASGRVTFKVDGEFHVDLTIADEDLEKQYWFIDFRYDFSPAPASLSPALRAYLEGCVNEALSKEGLAGCYRCLHEFVLTSKINELKRQAVKLSRTSWTGTLSVEPLNRALAIQYWTSRAVTTGTKSWILLAVNSGRKPDVTVQDERATSFIVAKWYRNGKEVKDVDVELDLKRLSAESLLTDAIGRHIDSILTSVHDKLLTAARYKDGEASLVLDLCRSDPAASSLSMQVGRTTLSVEPTTGVFVLKPQSKFTAPYEHQLNNGRNVADDGAACLENVRCAVMEDEMQRRGSMMGWRVRKPPLTVEETKTATRLRTWTRALWLQRDGWGAGWFMAVFLGASSDEWWLVEVSAAEAGINRRSPMAEGFTKGGGRSVKFKSKLPLPKGQLDLTDDFWSKLTLFTTGMMTQSMDVRELQRHKIKSRLSDGTDLSASRPVRLPSLEIPLSAVFPSMATTTREGDLSAQDVELFSLMQKYTGAALTMRRAWADDVVQLNFVGMRSRPDGELVCLSEAVVRVRKRSRLAALKDMVDGGVVYRPRRGEFSVQLERRLGEPMVEALRTRIKAVDRFVNMVEALDRAGGSLSTEEMTLGRVTFCYGEDRAWRLELELSSDEMRISVSPGNPHLRVMDLMRRLVNSDGGIGALIAWLPASLPALQAVSAMESHWEAAGSRGRLTLTMKSPAWMMLTYDVVDGRGRRRR
Length992
PositionTail
OrganismOphiocordyceps camponoti-rufipedis
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Hypocreomycetidae> Hypocreales> Ophiocordycipitaceae> Ophiocordyceps.
Aromaticity0.07
Grand average of hydropathy-0.289
Instability index39.46
Isoelectric point8.87
Molecular weight110649.28
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP15537
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     216.65|      53|     193|     367|     422|       1
---------------------------------------------------------------------------
  367-  422 (84.34/59.55)	CLHEF...VLTskiNELKRQAVKLSRTSWTGTLSVEPLNRALAIQYWTSRAVTTGTKSW
  568-  622 (86.86/54.19)	CLENVrcaVME...DEMQRRGSMMGWRVRKPPLTVEETKTATRLRTWT.RALWLQRDGW
  745-  780 (45.46/23.85)	......................SMATTTREGDLSAQDVELFSLMQKYTGAALTM.RRAW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      46.71|      14|      24|     876|     892|       2
---------------------------------------------------------------------------
  876-  892 (21.55/19.00)	LSTEEMtlgRVTFCYGE
  902-  915 (25.17/13.41)	LSSDEM...RISVSPGN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      74.46|      23|     298|     623|     648|       4
---------------------------------------------------------------------------
  623-  648 (32.77/38.99)	GAGWFMAvFLGASSDEwwLVEVSAAE
  933-  955 (41.68/30.21)	GIGALIA.WLPASLPA..LQAVSAME
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      62.82|      20|     193|      78|     109|       5
---------------------------------------------------------------------------
   81-  101 (30.21/42.46)	LNLNLNlNGARSRMNDLPDEI
  111-  130 (32.61/ 9.90)	LSLLLT.RLAQTSHNALQDKM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     135.30|      47|     193|     270|     319|       6
---------------------------------------------------------------------------
  270-  319 (74.66/69.00)	DLNTLLSL.RLNLDDY..DKIPPHF.......KDYDIASGRvtFKvDGEFHVDLTIADED
  459-  515 (60.64/44.59)	DVDVELDLkRLSAESLltDAIGRHIdsiltsvHDKLLTAAR..YK.DGEASLVLDLCRSD
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP15537 with Med14 domain of Kingdom Fungi
Unable to open file!