<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP15534

Description Uncharacterized protein
SequenceMTSSSRSSMGEQLPRQPQQMVLGATLALHRPLAHQHPASTPALPKLPTGGSQEAIDVGLPRPLASHSRHAPSLRCGSSKLRLELSDDPTPTPEPLPDACQPLSPAPPFRLVPIAKSISKPPSMSASTPVSAAAASSEKCLSQDHDSPLPMPHRPLHPPILLHTSPPISSPAPAQTRKDSRPKPYTVEVPSDAPRFISTPRHEASTKDSFSRGLYSGHADFFPWTGHHHEDEWSAEAIQKGTWDKGSSHETSSARLAIFPALRQKSGLTTLSTIFMNVLNQRRYRGQVTAPWTFKPPPRVTLTDTKREVWLKDLANPSISLRRLSRTIPHGIRGRTLLDQCLNKNVPTERAIWLAKCVGANEIRAFKRKGASGAFAMGGESKWVRDWTIFVEQFVESVASVFEDSEWKAKASYALRLATNLYSEHLMDRDHYLDWIVSGLESSSQARIPMWILIAKITIMDIVRSRKHARRLVYALVNHLSNVYCDADRDILAPLYHQLSSAVMMLLKRNPESFIVPTLWPKYREALKASLPAGDDACQNQYHRVNARNARLSVANTNSPPVGKQHLVRLLDLTLRARSDRELASKCLTIVEDRGELVKTLIEWATSAHRPGHAKTYVAARLLKAWKKLDMDATPVILAMMDGVRADDGVRKEMMFHLVGELIRSNVFSVPQYLQWLIGRGGLHEAAEIDAEKGPCATRLLVELPIHCLSESHQTQRKNLLRRAGHFSTVEEANDISNALKCVNDTAGLSQYLGSSHGRSKCLPLDRLLRKIASSSRALQTWVGIHLRDVLTAGLLTKMDSHGLVAVFESVRAIFETIDDFSSFLPVLKLCSVSSNFDLLAACTDTINSHLNVFLAMGCAEKLFDGLIDRLRFLGRQQGGAARPLLVALAGLGRRLPQREVVAKHLVRELVYTYRSNAVDACSPVSDNMTMQAHSAESEVSDQLDKLLASGNTIDHPTMNRLFRAIVPKLEAGWSKADESRRVFASLLTRLRMLDFQYFDRLMTDWTGHVGTKQHRPKLADMFPLLVSLGSISMSIILQTASTWSPPLDDMCLDSYPPIADSLVFVQELVQLVIMELPRSACLNAHEWYRFATQQKSARTENPKLLLLSIRNALIEYSALRTRHPDCQQPLDDGLYWHQLVESLKYLVVADSHAVANVLNASSLPLSAASFLRQIVTSLLVPESNGQGQMSFYEILDLTNELTMPFCLLKLNLDLSRAQQWTEDEAQSERQSRLEDFSKAMDRAIETRNTVWTSMLPYLSQDITRNISAQAHARFLDLIPCPKSMALQDEANSQERIHLAENLLRAIEAITSGQPPPKVAQLTGSLVDKLSDLSAIVACSQDGWAQTQQAVMDHWLPIFLRFITIHSTSAEPPAQPPSMGQASSARPSLSPSHEARARIILVLCTLLLDLNSRPQTTGGDLCQRVFDVALLLVDHLGDDVRNQCAKCILLMPGVLTNTSVSSDPRLYYLFSIPQLTLADNLRLAYREKSAVPYSAAARGIGAMFGIGPTANERLAPYVLRRWEILSEPTPNVGDNDTSLSLAMFDAIKIQ
Length1549
PositionKinase
OrganismOphiocordyceps australis
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Hypocreomycetidae> Hypocreales> Ophiocordycipitaceae> Ophiocordyceps.
Aromaticity0.06
Grand average of hydropathy-0.196
Instability index44.83
Isoelectric point8.71
Molecular weight171971.42
Publications









Function






Annotated function

Component of the SRB8-11 complex. The SRB8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The SRB8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.


Component of the srb8-11 complex. The srb8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The srb8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.



GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP15534
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     176.64|      43|     118|      29|      72|       1
---------------------------------------------------------------------------
   29-   72 (76.95/41.78)	HRPL.............AHQHPAStPAL....P.KL.PTGGSQEAIDVGLPRPLASHSRH.....APS
   81-  136 (40.77/16.61)	RLELsddptptpeplpdACQ.PLS.PAP....PfRLvPIAKS.....ISKP.PSMSASTPvsaaaASS
  152-  190 (58.92/27.42)	HRPL................HP...PILlhtsP.PI.SSPAPAQTRKDSRPKP...YTVE.....VPS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      45.32|      13|     118|     861|     873|       2
---------------------------------------------------------------------------
  861-  873 (23.11/13.01)	KLFDGLIDRLRFL
  981-  993 (22.21/12.21)	RVFASLLTRLRML
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     177.00|      57|     285|     374|     432|       3
---------------------------------------------------------------------------
  374-  432 (98.05/76.87)	FAMGGEskWVRDWTIFVEQFVE...SVASVFEDSEWKA.KASYALRLATNL....YSE.HLMDRDHYL
  655-  720 (78.95/55.10)	FHLVGE..LIRSNVFSVPQYLQwliGRGGLHEAAEIDAeKGPCATRLLVELpihcLSEsHQTQRKNLL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      73.98|      23|     415|     329|     352|       9
---------------------------------------------------------------------------
  329-  352 (40.71/31.53)	HGiRGRTL.LDQCLNKNVPTERAI..W
  756-  781 (33.27/20.11)	HG.RSKCLpLDRLLRKIASSSRALqtW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      93.16|      30|     213|    1290|    1325|      11
---------------------------------------------------------------------------
 1290- 1325 (37.52/39.90)	ANsqERihLAENLLRAIEAITsgQPPPKVAQLTGSL
 1509- 1538 (55.64/34.08)	AN..ER..LAPYVLRRWEILS..EPTPNVGDNDTSL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     109.18|      35|    1128|     246|     281|      12
---------------------------------------------------------------------------
  246-  281 (54.44/34.33)	SSHETSSARLAIFPALRQKSGLT.TLSTIFMNvLNQR
 1377- 1412 (54.75/30.45)	SMGQASSARPSLSPSHEARARIIlVLCTLLLD.LNSR
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP15534 with Med12 domain of Kingdom Fungi
Unable to open file!