<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP15527

Description Mediator of RNA polymerase II transcription subunit 5
SequenceMTSSSPPLDRITLMEFGDDGSNQQLVKQSVQEWSYFAYICLRDRVGIAEFKDLASDFHSNYPLPRAYIGHILLRPYPQQHVSIDPKTPQYIQVLTQLGYVDAPSILTPLYNFSSMHRRLEQLRPAGANPPDDAHKPSLTWDNSAWAEEVFFYHVIKMMVEGTAYKSAIDAYVLINIVSKWMNLFASVSNALEADMLGQDKNALLHEELDSSRAALVPLVLRLVETPAIVVLLKQQSGKGVRRHLAQGLANFVPTLPPGTPFTERLEMFRCGTLAELEPGGKERQAAAKAAMDELIPPNVALDNFVISDMAISTTRVGLYIYLNALLIGRPLLQDISFLAYLQNRHHGETQSSAINLILASFDVLANAVIRNERPKDAHLLRSFLTNKVPLLLCQLFAPQFSTASSEFCITQALNQVDTSLFPTASLMFDESRSNNPYTESVREDFCTACALHGLVQREHVERILGETSMSYEPSLEKFSKTKLVNECLSDPEKIQGLVRSLDNMDGNVGAVCHALVELIRQLCNSKETMTLKILCSQLAQKPQSLDILLLFEKVSAILDPLCNVLDNWRYDDDQTEYQPVYVEFGAILLLVFTFAYRYNLTPTLLEFSSTESCVLQILFRAHIPRLAAELIEKESEQLSGWVRGLFDSETGGLGDDLMSSCPPQQFYLLAATLFQKIVGAYACGQLNDESLKSGMEYMLDTFLLPSLVPAIRFLCECIWVEQKEQRSVIKILQLILMPSSISAEARAMLSSVKNLIAKPLEYALRSFQKQDPKNQDIEPLLRALRDNLPLSRRTGESEHTDVESWASSPNHGSSGGLGHTIQALVHWGVHNGINAMPPSYTHRQLISACKILGPESVLCMMLEEIRNQTDAGLGSIVYDVGVAMVCAPDVTNEPVTLLTGGQILDMTGNLTLGTTLSPTLRDCLKTEAEGCQELQKRDAVLAEIVVRLYRLVEEAMAMPQPQVILEAPGMELDLNGGAGDIGDAMVGVQASGMTVDGLDMGMGGAASDLGLAGGGGLETGSDGDLFGGMDTTMDMFGGWDGIDLGGS
Length1047
PositionTail
OrganismOphiocordyceps australis
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Hypocreomycetidae> Hypocreales> Ophiocordycipitaceae> Ophiocordyceps.
Aromaticity0.07
Grand average of hydropathy-0.013
Instability index48.18
Isoelectric point4.86
Molecular weight115175.74
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP15527
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     173.61|      53|     104|     870|     926|       1
---------------------------------------------------------------------------
  870-  926 (88.01/61.41)	DAGLGsivyDVGVAM..VCAPDVTNEPVTLLTGGQI..LDMTGNLTLGTTLSPTLRDCLKT
  975- 1031 (85.60/50.88)	NGGAG....DIGDAMvgVQASGMTVDGLDMGMGGAAsdLGLAGGGGLETGSDGDLFGGMDT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      51.35|      16|      24|     604|     619|       3
---------------------------------------------------------------------------
  604-  619 (27.19/16.59)	LLEFSSTE.SCVLQILF
  630-  646 (24.16/13.94)	LIEKESEQlSGWVRGLF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      70.93|      22|      24|     492|     515|       4
---------------------------------------------------------------------------
  492-  515 (33.32/28.31)	EKIQGLVRSLDNMDGNVgaVCHAL
  517-  538 (37.61/24.71)	ELIRQLCNSKETMTLKI..LCSQL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      91.35|      28|      31|     653|     683|       5
---------------------------------------------------------------------------
  653-  683 (46.01/33.83)	LGDDLMSSCPPqqfYLLAATLFQKIVGA..YAC
  686-  715 (45.34/25.36)	LNDESLKSGME...YMLDTFLLPSLVPAirFLC
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     101.97|      30|      35|       9|      43|       6
---------------------------------------------------------------------------
   11-   42 (49.25/49.23)	ITLMEFGDDGSNqqLVKQSVQEWSYFAYICLR
   45-   74 (52.72/31.08)	VGIAEFKDLASD..FHSNYPLPRAYIGHILLR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      58.39|      16|      35|     398|     413|       7
---------------------------------------------------------------------------
  398-  413 (28.46/17.21)	PQFSTASSEFCITQAL
  436-  451 (29.93/18.42)	PYTESVREDFCTACAL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      75.69|      23|      33|     195|     217|       8
---------------------------------------------------------------------------
  195-  217 (37.30/24.35)	MLGQDKNALLHEELDSSRAALVP
  231-  253 (38.39/25.29)	LLKQQSGKGVRRHLAQGLANFVP
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP15527 with Med5 domain of Kingdom Fungi
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