<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP15527
Description |
Mediator of RNA polymerase II transcription subunit 5 |
Sequence | MTSSSPPLDRITLMEFGDDGSNQQLVKQSVQEWSYFAYICLRDRVGIAEFKDLASDFHSNYPLPRAYIGHILLRPYPQQHVSIDPKTPQYIQVLTQLGYVDAPSILTPLYNFSSMHRRLEQLRPAGANPPDDAHKPSLTWDNSAWAEEVFFYHVIKMMVEGTAYKSAIDAYVLINIVSKWMNLFASVSNALEADMLGQDKNALLHEELDSSRAALVPLVLRLVETPAIVVLLKQQSGKGVRRHLAQGLANFVPTLPPGTPFTERLEMFRCGTLAELEPGGKERQAAAKAAMDELIPPNVALDNFVISDMAISTTRVGLYIYLNALLIGRPLLQDISFLAYLQNRHHGETQSSAINLILASFDVLANAVIRNERPKDAHLLRSFLTNKVPLLLCQLFAPQFSTASSEFCITQALNQVDTSLFPTASLMFDESRSNNPYTESVREDFCTACALHGLVQREHVERILGETSMSYEPSLEKFSKTKLVNECLSDPEKIQGLVRSLDNMDGNVGAVCHALVELIRQLCNSKETMTLKILCSQLAQKPQSLDILLLFEKVSAILDPLCNVLDNWRYDDDQTEYQPVYVEFGAILLLVFTFAYRYNLTPTLLEFSSTESCVLQILFRAHIPRLAAELIEKESEQLSGWVRGLFDSETGGLGDDLMSSCPPQQFYLLAATLFQKIVGAYACGQLNDESLKSGMEYMLDTFLLPSLVPAIRFLCECIWVEQKEQRSVIKILQLILMPSSISAEARAMLSSVKNLIAKPLEYALRSFQKQDPKNQDIEPLLRALRDNLPLSRRTGESEHTDVESWASSPNHGSSGGLGHTIQALVHWGVHNGINAMPPSYTHRQLISACKILGPESVLCMMLEEIRNQTDAGLGSIVYDVGVAMVCAPDVTNEPVTLLTGGQILDMTGNLTLGTTLSPTLRDCLKTEAEGCQELQKRDAVLAEIVVRLYRLVEEAMAMPQPQVILEAPGMELDLNGGAGDIGDAMVGVQASGMTVDGLDMGMGGAASDLGLAGGGGLETGSDGDLFGGMDTTMDMFGGWDGIDLGGS |
Length | 1047 |
Position | Tail |
Organism | Ophiocordyceps australis |
Kingdom | Fungi |
Lineage | Eukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes>
Hypocreomycetidae> Hypocreales> Ophiocordycipitaceae> Ophiocordyceps.
|
Aromaticity | 0.07 |
Grand average of hydropathy | -0.013 |
Instability index | 48.18 |
Isoelectric point | 4.86 |
Molecular weight | 115175.74 |
Publications | |
Function
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364142
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GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro
|
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro
|
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro
|
Interaction
Repeat regions
Repeats |
>MDP15527
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 173.61| 53| 104| 870| 926| 1
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870- 926 (88.01/61.41) DAGLGsivyDVGVAM..VCAPDVTNEPVTLLTGGQI..LDMTGNLTLGTTLSPTLRDCLKT
975- 1031 (85.60/50.88) NGGAG....DIGDAMvgVQASGMTVDGLDMGMGGAAsdLGLAGGGGLETGSDGDLFGGMDT
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 51.35| 16| 24| 604| 619| 3
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604- 619 (27.19/16.59) LLEFSSTE.SCVLQILF
630- 646 (24.16/13.94) LIEKESEQlSGWVRGLF
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 70.93| 22| 24| 492| 515| 4
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492- 515 (33.32/28.31) EKIQGLVRSLDNMDGNVgaVCHAL
517- 538 (37.61/24.71) ELIRQLCNSKETMTLKI..LCSQL
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 91.35| 28| 31| 653| 683| 5
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653- 683 (46.01/33.83) LGDDLMSSCPPqqfYLLAATLFQKIVGA..YAC
686- 715 (45.34/25.36) LNDESLKSGME...YMLDTFLLPSLVPAirFLC
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 101.97| 30| 35| 9| 43| 6
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11- 42 (49.25/49.23) ITLMEFGDDGSNqqLVKQSVQEWSYFAYICLR
45- 74 (52.72/31.08) VGIAEFKDLASD..FHSNYPLPRAYIGHILLR
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 58.39| 16| 35| 398| 413| 7
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398- 413 (28.46/17.21) PQFSTASSEFCITQAL
436- 451 (29.93/18.42) PYTESVREDFCTACAL
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 75.69| 23| 33| 195| 217| 8
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195- 217 (37.30/24.35) MLGQDKNALLHEELDSSRAALVP
231- 253 (38.39/25.29) LLKQQSGKGVRRHLAQGLANFVP
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